Abstract:Background: Von Willebrand Factor (vWF) is a multimeric adhesive protein to which platelets stick. It is physiologically released by activated endothelial cells during primary hemostasis. High Shear stress induced by hyperdynamic (splanchnic) circulation in advanced hepatic fibrosis as well as endotoxinemia caused by bacterial translocation may contribute to the increased levels of vWF releasing from that activated endothelium. Objective: The aim of the current work was to assess the stage of fibrosis changes … Show more
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