Role of plasma-rich fibrin in oral surgery

Kumar, K Retna; Genmorgan, K; Rahman, Sanjida; Rajan, Manoj; Kumar, Tarun; Prasad, Venkat

doi:10.4103/0975-7406.191963

Cited by 18 publications

(5 citation statements)

References 22 publications

(23 reference statements)

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“…PL is currently used in various studies in the field of regenerative medicine [ 20 , 21 , 22 , 23 , 24 ]. In this study, first we proved that PL is a superior, safe and easily available substitute for FBS in ADSC cell culture.…”

Section: Discussionmentioning

confidence: 99%

Secretome of Adipose-Derived Stem Cells Cultured in Platelet Lysate Improves Migration and Viability of Keratinocytes

Hermann

Peddi

Gerhards

et al. 2023

IJMS

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Chronic wounds depict a silent epidemic challenging medical professionals worldwide. Regenerative medicine uses adipose-derived stem cells (ADSC) in promising new therapies. In this study, platelet lysate (PL) as a xenogen-free substitute for foetal bovine serum (FBS) in ADSC culture was used to create an ADSC secretome containing cytokines for optimal wound healing conditions. The ADSC secretome was tested on keratinocytes for migrational behaviour and viability. Therefore, human ADSC were characterized under FBS (10%) and PL (5% and 10%) substitution, regarding morphology, differentiation, viability, gene and protein expression. ADSC were then cultured in 5% PL and their secretome was used for stimulation of keratinocyte migration and viability. To enhance the effect, ADSC were treated with Epithelial Growth Factor (EGF, 100 ng/mL) and hypoxia (1% O₂). In both PL and FBS groups, ADSC expressed typical stem cell markers. PL induced a significantly higher increase in cell viability compared to FBS substitution. ADSC secretome contained various beneficial proteins which enhance the wound healing capacity of keratinocytes. This could be optimized treating ADSC with hypoxia and EGF. In conclusion, the study shows that ADSC cultivated in 5 % PL can effectively support wound healing conditions and can be considered as a promising new therapy for individual treatment of chronic wound disorders.

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Section: Discussionmentioning

confidence: 99%

Secretome of Adipose-Derived Stem Cells Cultured in Platelet Lysate Improves Migration and Viability of Keratinocytes

Hermann

Peddi

Gerhards

et al. 2023

IJMS

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“…The following supporting information can be downloaded at: https: //www.mdpi.com/article/10.3390/dj12040101/s1, Table S1: References excluded and reason for the exclusion. References [4,12,[72][73][74][75][76][77][78][79][80][81] are cited in the supplementary materials. Funding: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.…”

Section: Supplementary Materialsmentioning

confidence: 99%

Effectiveness of Autologous Platelet Concentrates in the Sinus Lift Surgery: Findings from Systematic Reviews and Meta-Analyses

Gasparro,

Di Lauro,

Campana

et al. 2024

Dentistry Journal

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Maxillary sinus augmentation is one of the most predictable procedures for the rehabilitation of the posterior maxilla. The current overview aimed to summarize the findings provided by systematic reviews (SRs) and meta-analyses on the effectiveness of autologous platelet concentrates (APCs) in sinus lift and to assess the methodological quality of the included SRs. Three electronic databases have been explored. SRs and meta-analyses addressing the effectiveness of APCs in sinus lift technique were included. Clinical, radiographic and histomorphometric findings were considered for APCs as solely grafting materials and APCs in combination with biomaterials. Outcomes were implant survival rate (ISR), implant stability (IS), implant failure (IF), postoperative complications, histomorphometric findings, radiographic bone gain, bone volume and bone density. The methodological quality of the included SRs was assessed using the updated version of “A Measurement Tool to Assess Systematic Review” (AMSTAR-2). Thirty SRs were included. The methodological quality of the included reviews ranged from critically low (3 studies) to high (9 studies). The included SRs showed favorable clinical outcomes, short-term new bone formation and no biological complications when APCs were used both as solely graft material or in combination with other biomaterials. However, no significant additional effects in the long-term period were observed. APCs did not add any further positive effects compared to the physiological healing derived by the natural blood clot. The current overview of SRs highlighted the need for high-quality SRs evaluating the role of APCs in sinus lift though network meta-analyses, in order to identify the most powerful material for sinus lift augmentation. The use of APCs improves the healing of soft tissues and the postoperative quality of life in the short-term period. Thus, its application can be recommended.

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Section: Pathophysiology Of Scdmentioning

confidence: 99%

“…Sickle cell anemia (SCA) is an inherited multisystem disease caused by a defect in chromosome [10] . The sickle mutation itself is the result of a single base change (GAT→ GTT) in the sixth codon of exon 1 of the β-globin gene on short arm of chromosome 11 [10] . This change, in turn, results in replacement of the normal glutamic acid with valine at position 6 oftheβ-globin chain and the formation of sickle Hb.…”

Section: Pathophysiology Of Scdmentioning

confidence: 99%

Oral manifestations and management of sickle cell disease: a literature review

Soualem

Mainassara²,

Beenjelloun³

et al. 2022

International Journal of Surgery: Global Health

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Sickle cell disease (SCD) is an autosomal recessive hematological disorder that results in defective red blood cells (RBCs). These RBCs become sickled in shape, have a shortened lifespan leading to vascular occlusion and ischemia resulting in damaging effect on many organs throughout the body. There are numerous oral manifestations of SCD, although some may not be specific to SCD, it is important to recognize these clinical presentations and have a good understanding of the disease process to help in management of SCD from an oral health care perspective. The oral care of sickle cell patients requires specific precautions such as good management of local anaesthetics, rigorous anti-infective prophylaxis as well as controlled prescription of analgesics.

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Role of plasma-rich fibrin in oral surgery

Cited by 18 publications

References 22 publications

Secretome of Adipose-Derived Stem Cells Cultured in Platelet Lysate Improves Migration and Viability of Keratinocytes

Secretome of Adipose-Derived Stem Cells Cultured in Platelet Lysate Improves Migration and Viability of Keratinocytes

Effectiveness of Autologous Platelet Concentrates in the Sinus Lift Surgery: Findings from Systematic Reviews and Meta-Analyses

Oral manifestations and management of sickle cell disease: a literature review

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