2017
DOI: 10.1038/cddis.2017.301
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Role of peroxiredoxin2 downregulation in recurrent miscarriage through regulation of trophoblast proliferation and apoptosis

Abstract: Peroxiredoxin (Prdx) 2 is an antioxidant protein that utilizes its redox-sensitive cysteine groups to reduce hydrogen peroxide molecules and protect cells against oxidative damage from reactive oxygen species (ROS). However, its function in trophoblasts at the maternal–fetal interface has not been clarified yet. In this study, significantly lower Prdx2 expression was found in the first-trimester villous cytotrophoblasts of patients with recurrent miscarriage (RM) than in cytotrophoblasts from healthy controls.… Show more

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Cited by 72 publications
(49 citation statements)
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“…Data are expressed as the mean ± SEM*P < .05, **P < .01, ***P < .001, ****P < .0001, ns: not significant (ROS) are necessary for cell growth signaling during normal pregnancy, high levels of hypoxia-induced ROS lead to a transient or long-term cell cycle arrest and are correlated with various placental pathologies including RM, PE, and IUGR. 4 In accordance with its elevation in response to hypoxia, we observed that the expression of SPRY4 was increased in the first-trimester trophoblasts from patients with RM. Furthermore, in vitro experiments showed that SPRY4 overexpression restrained cell proliferation, impaired DNA synthesis, and accelerated apoptosis in the HTR8 cell line, while SPRY4 deficiency reversed these effects.…”
Section: Discussionsupporting
confidence: 70%
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“…Data are expressed as the mean ± SEM*P < .05, **P < .01, ***P < .001, ****P < .0001, ns: not significant (ROS) are necessary for cell growth signaling during normal pregnancy, high levels of hypoxia-induced ROS lead to a transient or long-term cell cycle arrest and are correlated with various placental pathologies including RM, PE, and IUGR. 4 In accordance with its elevation in response to hypoxia, we observed that the expression of SPRY4 was increased in the first-trimester trophoblasts from patients with RM. Furthermore, in vitro experiments showed that SPRY4 overexpression restrained cell proliferation, impaired DNA synthesis, and accelerated apoptosis in the HTR8 cell line, while SPRY4 deficiency reversed these effects.…”
Section: Discussionsupporting
confidence: 70%
“…40 Trophoblast dysfunctions resulted from the unbalanced level of trophoblast proliferation and apoptosis are critical factors to the development of RM. 4 In the past decade, SPRY genes have been considered as a general inhibitor of RTK-dependent signaling pathways, acting as tumour suppressors in several cancers via regulating cell fate.…”
Section: Discussionmentioning
confidence: 99%
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“…Unlike human embryonic ESCs, macaque ESCs do not respond to BMP4 treatment to promote differentiation to trophectoderm 58,59 , however, it is plausible that this cluster represents established TSCs that are positioned for differentiation. A more conservative analysis, K-means analysis, revealed a distinct axis of up or down-regulated genes between clusters 1 and 2, including NUCB2, APOE, PRDX2, and LDHA, that have previously been shown to have roles in trophoblast function [60][61][62][63][64] .…”
Section: Moreover Macaque St-3d and Evt Cells Secreted High Levels Omentioning
confidence: 96%