Abstract:To develop an effective treatment for muscle recovery, costimuli effect of cyclic stretch and hypoxia on the recovery of oxidative damaged skeletal muscle cells is investigated. C2C12 myoblast cells are differentiated into myotube in culture dish followed by seeding the myotubes in the microfluidic device for further growth. Hydrogen peroxide is used to induce oxidative stress on myotubes for mimicking intracellular muscle damage. Afterward, the damaged myotubes are recovered in either normoxia or hypoxia envi… Show more
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