Role of oxygen free radicals in cancer development

Dreher, D.; Junod, A.

doi:10.1016/0959-8049(95)00531-5

Cited by 746 publications

(464 citation statements)

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“…Free radicals cause different types of chemical changes in DNA, thus they could be mutagenic and involved in the etiology of cancer [123,124]. Cancer cells in particular, in comparison to normal cells, have higher levels of ROS and are more susceptible to mitochondrial dysfunction due to their higher metabolic rate [125].…”

Section: Cancermentioning

confidence: 99%

Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases

2014

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Free radicals and other oxidants have gained importance in the field of biology due to their central role in various physiological conditions as well as their implication in a diverse range of diseases. The free radicals, both the reactive oxygen species (ROS) and reactive nitrogen species (RNS), are derived from both endogenous sources (mitochondria, peroxisomes, endoplasmic reticulum, phagocytic cells etc.) and exogenous sources (pollution, alcohol, tobacco smoke, heavy metals, transition metals,

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Section: Cancermentioning

confidence: 99%

Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases

2014

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“…© 2002 Wiley-Liss, Inc. Key words : etheno DNA adducts; urinary excretion; salt; polyunsaturated fatty acids; diet; cancer Oxidative stress is caused by a net imbalance of pro-oxidants to anti-oxidants in the cell and is implicated in carcinogenesis. 1 Dietary components are one of the major sources of exogenous pro-oxidants and anti-oxidants for the body. Modulation of antioxidant intake could influence the pro-/anti-oxidant balance resulting in reduced cellular oxidative stress.…”

mentioning

confidence: 99%

“…1 Dietary components are one of the major sources of exogenous pro-oxidants and anti-oxidants for the body. Modulation of antioxidant intake could influence the pro-/anti-oxidant balance resulting in reduced cellular oxidative stress.…”

mentioning

confidence: 99%

Urinary level of 1,N⁶ ‐ethenodeoxyadenosine, a marker of oxidative stress, is associated with salt excretion and ω6‐polyunsaturated fatty acid intake in postmenopausal Japanese women

Hanaoka

Nair

Takahashi

et al. 2002

Intl Journal of Cancer

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Excretion of 1,N 6 -ethenodeoxyadenosine (⑀dA), a marker for lipid peroxidation (LPO)-derived DNA damage was analyzed in urine of nonsmoking postmenopausal women participating in a dietary intervention trial in Northern Japan. Hereby the efficacy of dietary consultation in reducing salt and increasing vitamin C and carotenes during 1 year was estimated. Thirty postmenopausal women, 60 -69 years of age, from the intervention group and 30 age-matched women from the control group were randomly selected. The subjects completed a self-administered diet history questionnaire and in the pre-and post-intervention period 48 hr urine and fasting blood samples were collected. ⑀dA in urine was analyzed by an immuno-precipitation-high performance liquid chromatography-fluorescence detection method. ⑀dA excretion (/48 hr) in the 59 postmenopausal Japanese women with complete urine collection ranged from 12-226 pmol at the pre-intervention. At the pre-intervention, ⑀dA excretion was positively associated with urinary salt excretion (R ‫؍‬ 0.33, p ‫؍‬ 0.01) and -6 polyunsaturated fatty acid intake (%energy value, R ‫؍‬ 0.28, p ‫؍‬ 0.03) in the 59 women. The average ⑀dA excretion in the intervention group was 61 pmol at pre-intervention and 44 pmol at post-intervention (p ‫؍‬ 0.14). In the control group, it was 58 pmol at pre-intervention and 75 pmol at post-intervention (p ‫؍‬ 0.24). During the intervention period, 18/29 (62%) of the subjects in the intervention group exhibited the decreased excretion and 10/26 (38%) in the control group (p ‫؍‬ 0.08). Results from this pilot study suggest urinary ⑀dA as a potential biomarker of DNA damage possibly derived from salt-induced inflammation and LPO; further exploration of ⑀dA in human biomonitoring studies is warranted. © 2002 Wiley-Liss, Inc. Key words : etheno DNA adducts; urinary excretion; salt; polyunsaturated fatty acids; diet; cancer Oxidative stress is caused by a net imbalance of pro-oxidants to anti-oxidants in the cell and is implicated in carcinogenesis. 1 Dietary components are one of the major sources of exogenous pro-oxidants and anti-oxidants for the body. Modulation of antioxidant intake could influence the pro-/anti-oxidant balance resulting in reduced cellular oxidative stress. Validation and application of biomarkers of oxidative stress in dietary intervention studies is essential in evaluating effective prevention strategies against oxyradicals and associated malignancies.Etheno ⑀-DNA adducts are formed as stable DNA base adducts from reactive aldehydes such trans-4-hydroxy-2-nonenal generated during the oxidative stress or lipid peroxidation (LPO). 2 It has been demonstrated that ⑀-DNA adducts were present in asymptomatic liver of humans, suggesting that these lesions could arise from endogenously formed LPO products. 3 An in vitro study showed that arachidonic acid in the presence of LPO inducing compounds led to the generation of ⑀-DNA-base adducts. 4 Our previous study also revealed that ⑀-adducts were increased in WBC-DNA of the females as a result of...

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“…[11][12][13] Reactive oxygen species (ROS) cause DNA damage and may induce genetic changes in all stages (initiation, promotion and progression) of carcinogenesis. 14) ROS are produced by ionizing radiation, mutagens and carcinogens, and also during endogenous oxygen metabolism in cells. 15) 8-Hydroxydeoxyguanosine (8-OH-dG) is one of the major forms of DNA damage induced by ROS.…”

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confidence: 99%

“…23) G⋅C to T⋅A transversions have been detected in the ras oncogene and the p53 tumor suppressor gene in human lung cancers. 14,24) It is suspected that ROS might be involved in the mechanism of lung carcinogenesis. 14) The 8-OH-dG levels have been analyzed in human peripheral blood, stomach, liver, breast, and lung tissues.…”

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confidence: 99%

Untitled

1998

Japanese Journal of Cancer Research

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The 8-hydroxydeoxyguanosine (8-OH-dG) levels in the peripheral parts of human lung tissues were compared between lung cancer patients (n= = = =70) and non-cancer patient controls (n= = = =15). An increased level of 8-OH-dG was observed in the lung cancer group, in both the adenocarcinoma and non-adenocarcinoma (mainly squamous cell carcinoma) groups, as compared to the non-cancer control group. This result suggests that reactive oxygen species are partly involved in the induction of lung carcinomas (both adenocarcinoma and non-adenocarcinoma).

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Role of oxygen free radicals in cancer development

Cited by 746 publications

References 79 publications

Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases

Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases

Urinary level of 1,N⁶ ‐ethenodeoxyadenosine, a marker of oxidative stress, is associated with salt excretion and ω6‐polyunsaturated fatty acid intake in postmenopausal Japanese women

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Role of oxygen free radicals in cancer development

Cited by 746 publications

References 79 publications

Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases

Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases

Urinary level of 1,N6 ‐ethenodeoxyadenosine, a marker of oxidative stress, is associated with salt excretion and ω6‐polyunsaturated fatty acid intake in postmenopausal Japanese women

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Urinary level of 1,N⁶ ‐ethenodeoxyadenosine, a marker of oxidative stress, is associated with salt excretion and ω6‐polyunsaturated fatty acid intake in postmenopausal Japanese women