Role of oxidative stress in skin aging

Kozina, L S; Борзова, Ю В; Arutiunov, V A; Ryzhak, G. A.

doi:10.1134/s2079057013010086

Cited by 16 publications

(11 citation statements)

References 52 publications

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“…Oxidative stress plays a predominant role in the induction of skin aging. 6 The underlying mechanisms promoting skin aging comprise enhanced concentrations of reactive oxygen species (ROS) due to repetitive UV irradiation and reduced antioxidant defense occurring both in photoaging and in intrinsic aging. Enhanced ROS concentrations such as superoxide anion radicals as well as enhanced hydrogen peroxide concentrations drive pro-aging signaling pathways with the induction of NF-kB-dependent inflammation and AP-1-dependent matrix degradation.…”

Section: Discussionmentioning

confidence: 99%

The role of vitamin C in pushing back the boundaries of skin aging: an ultrasonographic approach

Crişan¹,

Román²,

Crışan³

et al. 2015

CCID

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BackgroundImagistic methods stand as modern, non-invasive, and objective means of assessing the impact of topical cutaneous therapies.ObjectiveThis study focuses on the evaluation, by high-frequency ultrasound, of the cutaneous changes induced by topical use of a vitamin C complex at facial level.MethodsA vitamin C-based solution/Placebo moisturizer cream was applied at facial level of 60 healthy female subjects according to a predetermined protocol. Ultrasonographic images (Dermascan C, 20 MHz) were taken from zygomatic level initially, at 40 and 60 days after therapy. The following parameters were assessed for every subject: thickness of the epidermis and dermis (mm), the number of low (LEP), medium (MEP), high echogenic pixels (HEP), and the number of LEP in the upper dermis/lower dermis (LEPs/LEPi).ResultsLEP decreased significantly in all age categories during and after therapy, but especially in the first 2 age intervals, up to the age of 50 (P=0.0001). MEP and HEP, pixel categories that quantify protein synthesis also had an age-dependent evolution in the study, increasing significantly in all age categories but most of all in the first age interval (P=0.002). Our ultrasonographic data suggest that collagen synthesis increased significantly after topical vitamin C therapy, and is responsible for the increase in MEP and HEP and consequent decrease of the LEP.ConclusionOur study shows that topically applied vitamin C is highly efficient as a rejuvenation therapy, inducing significant collagen synthesis in all age groups with minimal side effects.

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Section: Discussionmentioning

confidence: 99%

The role of vitamin C in pushing back the boundaries of skin aging: an ultrasonographic approach

Crişan¹,

Román²,

Crışan³

et al. 2015

CCID

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“…However, these unsaturated fatty acids can undergo lipid oxidation, leading to loss of their functionality, quality deterioration of the product (rancidity), and formation of reactive oxygen species (ROS). ROS can lead to oxidative stress and inflammatory conditions of the skin and can furthermore result in premature skin aging (Kozina et al, ). To control lipid oxidation, antioxidants can be added.…”

Section: Introductionmentioning

confidence: 99%

Improving Oxidative Stability of Skin‐Care Emulsions with Antioxidant Extracts from Brown Alga Fucus vesiculosus

Hermund

Heung

Thomsen

et al. 2018

J Americ Oil Chem Soc

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Skin-care products are known delivery systems of functional lipids that can enhance the natural defense of skin. Unsaturated lipids, e.g., linoleic acids, are more susceptible to lipid oxidation than saturated lipids. Therefore, lipid oxidation must be prevented to preserve the functionality of the unsaturated lipids in skin-care products. The antioxidant properties of two Fucus vesiculosus extracts (water extract [WE] and 80% [v/v] ethanol extract [EE]) were evaluated. Both extracts had high in vitro antioxidant properties and a high phenolic content. The antioxidant efficacy of the extracts was evaluated by addition of 0.05% and 0.1% (w/w) freeze-dried extracts to facial cream formulations. The cream was stored up to 42 days (dark, 20 C) and the oxidative stability was determined by following tocopherol consumption and development in peroxides and secondary oxidation products. The results showed that EE was able to reduce the peroxide oxidation rate from 84.8% (control without extract) to 41.3%. Furthermore, a higher efficacy was observed for EE over WE. This was most likely related to higher phenolic content, high radicalscavenging activity, and moderate metal-chelating ability. However, WE indicated regeneration of tocopherols by amphiphilic polyphenolic phlorotannins, with interfacial properties. The results show that F. vesiculosus extracts rich in antioxidative phlorotannins can play an important role in reducing lipid oxidation and maintaining the quality of cream.

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“…One group includes gene-coded antioxidant enzymes, such as superoxide dismutase, catalase, peroxidase, thioredoxin systems, and glutathione systems; another group includes non-gene coded metabolic products, such as uric acid, ascorbic acid, α-tocopherol, carotenes, glutathione, lipoic acid, and ubiquinol [9,10,11,12].…”

Section: Introductionmentioning

confidence: 99%

Determination of Antioxidant Activity in Garlic (<i>Allium sativum</i>) Extracts Subjected to Boiling Process <i>in vitro</i>

Liu¹,

Yang²,

Yao³

et al. 2014

JFNR

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Garlic is a vegetable known to be a good antioxidant food resource around the world. Several studies on the antioxidant activity of garlic, mainly conducted using one or two methods, have been reported. However, comparison of the antioxidant activity of garlic before and after cooking is rarely reported. In this study, we compared the antioxidant activity of garlic aqueous and methanol extracts processed before and after boiling to mimic the cooking process. By testing the antioxidant activities of the extracts in different chemical mimic systems in vitro, namely, ABTS [2, 2'-azino-bis (3-ethylbenzthiazoline-6-sulfonic acid)] and DPPH (2, 2-diphenyl-1-picrylhydrazyl) radical scavenging activities, reducing power, and metal chelating ability, we found the following data: (1) no significant difference was observed on the ABTS radical scavenging activities of garlic aqueous and methanol extracts before and after boiling process; (2) the reducing power of garlic aqueous and methanol extracts decreased by 25.9% and 14.1%, respectively, whereas the metal chelating activity of boiled garlic aqueous extracts increased by 54.7%; and (3) DPPH radical scavenging test may not be suitable to examine the garlic extracts. In addition, the ABTS radical scavenging activities of garlic extracts were very stable at pH ranges similar in human bodies, and both sulfhydryl and phenolic compounds were probably responsible for the antioxidant ability of garlic. The boiling process destroyed only a small part of garlic bio-ingredients related to antioxidant activity properties.

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Role of oxidative stress in skin aging

Cited by 16 publications

References 52 publications

The role of vitamin C in pushing back the boundaries of skin aging: an ultrasonographic approach

The role of vitamin C in pushing back the boundaries of skin aging: an ultrasonographic approach

Improving Oxidative Stability of Skin‐Care Emulsions with Antioxidant Extracts from Brown Alga Fucus vesiculosus

Determination of Antioxidant Activity in Garlic (<i>Allium sativum</i>) Extracts Subjected to Boiling Process <i>in vitro</i>

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