2021
DOI: 10.1016/j.redox.2021.101861
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Role of oxidative stress in the dysfunction of the placental endothelial nitric oxide synthase in preeclampsia

Abstract: Preeclampsia (PE) is a multifactorial pregnancy disease, characterized by new-onset gestational hypertension with (or without) proteinuria or end-organ failure, exclusively observed in humans. It is a leading cause of maternal morbidity affecting 3–7% of pregnant women worldwide. PE pathophysiology could result from abnormal placentation due to a defective trophoblastic invasion and an impaired remodeling of uterine spiral arteries, leading to a poor adaptation of utero-placental circulation. This would be ass… Show more

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Cited by 125 publications
(75 citation statements)
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“…This abnormal increase in NOX-1 and NOX-2 could critically affect the blood vessels of the cord, which in turn can negatively affect its function. NOX-1 is the main producer of ROS during pregnancy, and its levels are substantially increased under pathological conditions [ 38 , 39 , 40 ]. NOX-2 levels are also elevated due to the development of gestational complications and are closely involved in the deregulation of some key cellular products, such as vascular endothelial growth factor (VEGF), and in the process of angiogenesis [ 41 ].…”
Section: Discussionmentioning
confidence: 99%
“…This abnormal increase in NOX-1 and NOX-2 could critically affect the blood vessels of the cord, which in turn can negatively affect its function. NOX-1 is the main producer of ROS during pregnancy, and its levels are substantially increased under pathological conditions [ 38 , 39 , 40 ]. NOX-2 levels are also elevated due to the development of gestational complications and are closely involved in the deregulation of some key cellular products, such as vascular endothelial growth factor (VEGF), and in the process of angiogenesis [ 41 ].…”
Section: Discussionmentioning
confidence: 99%
“…The etiology of GH/PE is not fully understood yet. Among many factors, genetic, metabolic, immunological and environmental factors are taken into consideration [ 2 , 7 , 29 , 30 , 31 ]. Excessive oxidative stress, inflammation and endothelial disorders are key elements of pathogenesis of GH and PE [ 2 , 7 , 32 ].…”
Section: Discussionmentioning
confidence: 99%
“…Considering the key roles of inflammatory and oxidative pathways in biological offence provoked by endothelin and TXA2 pathways (Possomato-Vieira and Khalil 2016;Guerby et al 2021), the possible involvement of these molecular entities in cardiorenal complications seen in offspring of PE rats were investigated. For this purpose, cardiac and renal levels of TNF-α, a potent inflammatory cytokine with a major role in cellular apoptosis and necrosis (Kalantar et al 2013;Sallam et al 2018), and 8-isoprostane, a reliable marker of lipid peroxidation and oxidative stress (Braekke et al 2006), were measured in adult offspring.…”
Section: Discussionmentioning
confidence: 99%