Role of oxidative stress enzymes in open-angle glaucoma

Abstract

Purpose To investigate the role of oxidative stress and lipid peroxidation in the pathogenesis of primary open-angle glaucoma (POAG). Materials and methods The activities of myeloperoxidase (MPO), catalase (CAT), and the levels of plasma malondialdehyde (MDA) were measured in 40 (15 men and 25 women) patients with POAG and 60 (30 men and 30 women) healthy controls. Results There was no significant difference in the activities of CAT and MPO between the POAG patients and the controls. However, the plasma MDA level was significantly higher in patients than the controls. Conclusion The results of this preliminary study suggest that the possible alterations of plasma MDA levels may be associated with the pathogenesis of POAG, but further research is needed to understand the role of oxidative damage in this important disorder of aging.

Oxidative and Anti-Oxidative Stress Markers in Chronic Glaucoma: A Systematic Review and Meta-Analysis

“…Overall, the studies performed best in the methods section and worst in the discussion section. All studies except one mentioned ethical approval [43]. …”

“…Levels of oxidant or antioxidant markers were evaluated in serum in 12 studies [27,28,29,31,32,34,35,39,40,43,45,48], in aqueous humor in six studies [30,36,37,38,44,47], or both in three studies [33,41,42]. One study measured the markers in blood hemolysate [46].…”

“…The markers were measured in different types of glaucoma: only in primary open angle glaucoma (POAG) [29,30,36,37,39,41,43,44,45,46,48], only in primary angle closure glaucoma (PACG) [27,31], only in pseudoexfoliation glaucoma (PEG) [28,32,33], in both POAG and PACG [38], in both POAG and PEG [35,42,47], in both POAG, PACG and PEG [40], or it was not specified [34]. Inclusion criteria for glaucoma patients were similar for most studies [27–33,35–39,41,43,46,47].…”

“…Inclusion criteria for glaucoma patients were similar for most studies [27–33,35–39,41,43,46,47]. Patients had to have a vertical cup/disc ratio of 0.5 or higher and a typical glaucomatous defect at the visual field (standard automatized visual field analyser).…”

Neuroprotective Effects of Crocin against Oxidative Stress Induced by Ischemia/Reperfusion Injury in Rat Retina

“…Gherghel et al [10] deduced that the plasma level of GSH was significantly reduced in glaucoma subjects compared with healthy controls. Moreover, Yildirim et al [11] revealed that the plasma level of malondialdehyde (MDA) in glaucoma patients was significantly elevated. It seems reasonable to consider the potential use of defined antioxidants in the treatment of retinal ischemia diseases.…”