Role of Orosomucoid in the Regulation of Plasma Proteolytic Systems during Experimental Renal Failure

Abstract

Activity of plasma proteolytic systems was studied in outbred albino rats with acute renal failure. The possibility of treating this disorder with acute phase protein alpha-1-acid glycoprotein was evaluated. Acute renal failure was induced by single subcutaneous injection of mercury chloride (II). The parameters were evaluated on day 5 postinjection. alpha-1-Acid glycoprotein in a dose of 150 mg/kg was administered 3 times. Acute renal failure was accompanied by activation of the complement system and fibrin formation (with factors for the intrinsic and common pathways of blood coagulation) and inhibition of the fibrinolytic system and antithrombin activity. Treatment with glycoprotein was followed by partial recovery of fibrin formation and complement system. These changes were probably related to accumulation of glycoprotein in the renal tissue and in situ protective effect.

Placental growth factor, pregnancy-associated plasma protein-A, soluble receptor for advanced glycation end products, extracellular newly identified receptor for receptor for advanced glycation end products binding protein and high mobility group box 1 levels in patients with acute kidney injury: a cross sectional study

“…Orosomucoid, being an acute phase protein, contributes to immune response in inflammatory states modulating chemotaxis of neutrophils, superoxide generation and aggregation [46]. On the other hand, a recent study in a murine model of acute renal failure has shown that orosomucoid partially restored activity of clotting and complement systems in acute renal failure [47]. This effect may be due to accumulation of orosomucoid in renal tissue and its protective action in situ.…”

Influence of Bestim Immunomodulator on Immune Status and Free-Radical Oxidation in Patients With Chronic Pyelonephritis Associated With Urolithiasis

“…После удаления камня и вос-становления проходимости мочевыводящих путей используются различные консерватив-ные терапевтические подходы при МКБ. Учи-тывая роль оксидативного стресса и факторов иммунной системы в патогенезе калькулезно-го пиелонефрита и его осложнений, целесооб-разным является включение в комплексную терапию препаратов антиоксидантного и им-муномодулирующего действия [4,[7][8][9][10][11][12][13][14]. Среди последних интерес вызывает синтетический дипептид γ-D-глутамил-L-триптофан натрие-вая соль -«Бестим», который успешно при-меняется при различных инфекционных и ал-лергических заболеваниях, в том числе при пиелонефрите.…”

Effect of Erythropoietin on Activity of Plasma Proteolytic Systems during Experimental Renal Failure

“…Treatment with erythropoietin led to partial recovery of fi brin formation and fi brinolysis. Under analytical in vitro conditions, 30-min incubation of whole blood from healthy donors with erythropoietin in doses of 1.9-30.0 U/liter was followed by a dose-dependent inhibition of the fi brin formation system and activation of fi brinolysis.Dysregulation of plasma proteolytic systems of fi brin formation and fi brinolysis and the anticoagulant system can serve as a key pathogenetic factor for thrombohemorrhagic complications in renal failure of different genesis [4,13]. Erythropoietin (EPO) is a glycoprotein (molecular weight 30.4 kDa) responsible for proliferation, differentiation, and inhibition of apoptosis in glycoprotein-sensitivebone marrow erythroid lineage cells.…”

“…Dysregulation of plasma proteolytic systems of fi brin formation and fi brinolysis and the anticoagulant system can serve as a key pathogenetic factor for thrombohemorrhagic complications in renal failure of different genesis [4,13]. Erythropoietin (EPO) is a glycoprotein (molecular weight 30.4 kDa) responsible for proliferation, differentiation, and inhibition of apoptosis in glycoprotein-sensitivebone marrow erythroid lineage cells.…”