Effect of Erythropoietin on Activity of Plasma Proteolytic Systems during Experimental Renal Failure

Abstract

Activity of plasma proteolytic systems (fibrin formation, fibrinolysis, and anticoagulant system) and the possibility for correction of changes in these systems with erythropoietin were studied in experiments on outbred albino rats with experimental renal failure. Renal failure was induced by a single subcutaneous injection of mercury chloride (II). The parameters were estimated on day 5 postinjection. Erythropoietin in a single dose of 5000 U/kg was administered on day 4. Renal failure was accompanied by activation of fibrin formation (with factors of the common and intrinsic pathways of blood coagulation), increase in antithrombin activity, and inhibition of the fibrinolytic system. Treatment with erythropoietin led to partial recovery of fibrin formation and fibrinolysis. Under analytical in vitro conditions, 30-min incubation of whole blood from healthy donors with erythropoietin in doses of 1.9-30.0 U/liter was followed by a dose-dependent inhibition of the fibrin formation system and activation of fibrinolysis.

Influence of Bestim Immunomodulator on Immune Status and Free-Radical Oxidation in Patients With Chronic Pyelonephritis Associated With Urolithiasis

“…После удаления камня и вос-становления проходимости мочевыводящих путей используются различные консерватив-ные терапевтические подходы при МКБ. Учи-тывая роль оксидативного стресса и факторов иммунной системы в патогенезе калькулезно-го пиелонефрита и его осложнений, целесооб-разным является включение в комплексную терапию препаратов антиоксидантного и им-муномодулирующего действия [4,[7][8][9][10][11][12][13][14]. Среди последних интерес вызывает синтетический дипептид γ-D-глутамил-L-триптофан натрие-вая соль -«Бестим», который успешно при-меняется при различных инфекционных и ал-лергических заболеваниях, в том числе при пиелонефрите.…”

Effect of Erythropoietin on Lymphocytes Apoptosis in Experimental Chronic Renal Failure

“…Pleiotropic effects of erythropoietin (EPO) not related to its erythropoiesis-stimulating effects and observed under conditions of endogenous EPO defi ciency in chronic renal failure (CRF) attracted much recent attention [1,3,4]. We have previously demonstrated the infl uence of EPO on the hemostatic system, including lymphocyte-platelet interactions, proportions and functional activity of the effectors of innate and adaptive immunity in CRF [4,5].…”

Effect of Local Application of Epidermal Growth Factor on Innate Immunity and Cell Composition of Destruction Focus in Experimental Thermal Injury

“…Investigation of the endogenous homeostasis regulators is a highly topical area in both fundamental and applied medical sciences, as far as it expands our understanding of body functions and promotes the development of new-generation drugs [2][3][4]. Immune system dysfunction in thermic injury (TI) is responsible for purulent-septic complications, septic shock, multiple organ failure and lethality; therefore, multitropic therapy in combustiology should include immunocorrecting approaches [1,2,10].…”

“…Immune system dysfunction in thermic injury (TI) is responsible for purulent-septic complications, septic shock, multiple organ failure and lethality; therefore, multitropic therapy in combustiology should include immunocorrecting approaches [1,2,10]. In this context, recombinant human epidermal growth factor (rhEGF) is of great interest.…”