Role of omega-3 fatty acids in health and disease

Fernandes, Gabriel; Venkatraman, Jaya T.

doi:10.1016/s0271-5317(05)80282-9

Cited by 123 publications

(59 citation statements)

References 48 publications

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“…An unbeneficial fatty acid composition of dietary lipids (saturated fatty acid, n-6 unsaturated fatty acid) was demonstrated to increase the risk to contract coronary heart disease (Kritchevsky 1998, Hu et al 1999. The polyunsaturated fatty acids (PUFAs), particularly n-3 PUFAs exert beneficial effects against cardiovascular and tumour diseases, inflammatory and immune disorders, and neurological dysfunctions (Fernandez & Venkatraman 1993, Burns & Spector 1994, Calder 1998. The conjugated linoleic acids (e.g.…”

Section: Introductionmentioning

confidence: 99%

The fatty acid composition of longissimus <i>lumborum</i> muscle of suckling and earlyweaned dual-purpose wool/meat lambs

et al. 2012

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Twenty-four dual purpose (wool/meat) suckling and early weaned ram lambs were used to study the fatty acid profile in intramuscular fat of longissimus lumborum muscle and lipid oxidation in blood serum. At 60 days of age 12 rams were slaughtered as suckling lambs. The other 12 early weaned and fed according to standards by grass hay and concentrate, and slaughtered at 90 days of age. Suckling lambs had more polyunsaturated fatty acids (P≤0.01) than early-weaned lambs. Younger lambs obtained also higher values of n-3 fatty acids (P≤0.01) and lower n-6/n-3 ratio (P≤0.01) appropriate in relation to their contribution to human health. Muscle tissue of early-weaned lambs compared to suckling group was characterised by significantly higher c9,t11C18:2 content (P≤0.01), which is desirable in human diet with regard to its peculiarities. The higher amount (P≤0.01) of vaccenic acid, which is the substrate for rumenic acid formation, has been observed in early-weaned lambs also.

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Section: Introductionmentioning

confidence: 99%

The fatty acid composition of longissimus <i>lumborum</i> muscle of suckling and earlyweaned dual-purpose wool/meat lambs

et al. 2012

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“…Dietary fish oil has been demonstrated to: protect mice against infection with numerous extracellular bacterial pathogens, regulate serum triglycerides and cholesterol levels, inhibit synthesis of lipid mediators of inflammation (PGE 2 , arachidonic acid, cyclo-oxygenase, 5-lipoxygenase), alter cellular functions of polymorphonuclear leukocytes, modulate lymphocyte proliferation and cytokine production, and increase endogenous host anti-oxidant capacity, e.g., SOD and catalase (Alam et al, 1991;Blok et al, 1992;Fernandes and Venkataraman, 1993). These effects have been proposed to account for the potent anti-inflammatory properties of omega (ω)-3 fatty acids (FA) in human, non-human primate, and rodent disease models.…”

Section: Introductionmentioning

confidence: 99%

Omega-3 Fatty Acid Effect on Alveolar Bone Loss in Rats

et al. 2006

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Gingival inflammation and alveolar bone resorption are hallmarks of adult periodontitis, elicited in response to oral micro-organisms such as Porphyromonas gingivalis. We hypothesized that omega (ω)-3 fatty acids (FA) dietary supplementation would modulate inflammatory reactions leading to periodontal disease in infected rats. Rats were fed fish oil (ω-3 FA) or corn oil (n-6 FA) diets for 22 weeks and were infected with P. gingivalis. Rats on the ω-3 FA diet exhibited elevated serum levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), documenting diet-induced changes. PCR analyses demonstrated that rats were orally colonized by P. gingivalis; increased IgG antibody levels substantiated this infection. P. gingivalis-infected rats treated with ω-3 FA had significantly less alveolar bone resorption. These results demonstrated the effectiveness of an ω-3 FA-supplemented diet in modulating alveolar bone resorption following P. gingivalis infection, and supported that ω-3 FA may be a useful adjunct in the treatment of periodontal disease. Abbreviations: PUFA, polyunsaturated fatty acid; EPA, eicosapentanoic acid; DHA, docosahexanoic acid; and PCR, polymerase chain-reaction.

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“…In additional studies, we compared lard, corn oil, and fish oil at the 20% level on survival of B/W mice, and found that corn oil was intermediate between lard and fish oil (55). Thus, corn oil as a source of dietary lipid in these studies represents an intermediately effective lipid when life span is the measure of effectiveness.…”

Section: Fish Oil Fats and Autoimmune Disease In The Short-lived B/w mentioning

confidence: 93%

Effects of calorie restriction and ω-3 dietary fat on aging in short-and long-lived rodents

Troyer

Venkatraman

Fernandes

1998

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Aging is accompanied by a steady increase in the incidence of spontaneous tumors and a decline in immune function. Calorie restriction (CR) or supplementation with (0-3 fats prolongs life span, suppresses tumorigenesis, and ameliorates immune function in a variety of experimental models. We suggest that decreased oxidant stress and upregulation of apoptosis mediate the effects of calorie restriction on immunity and longevity. CR prolongs life span in several animal models and our studies have examined the effects of CR on the immune system and on tumorigenesis.

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Role of omega-3 fatty acids in health and disease

Cited by 123 publications

References 48 publications

The fatty acid composition of longissimus <i>lumborum</i> muscle of suckling and earlyweaned dual-purpose wool/meat lambs

The fatty acid composition of longissimus <i>lumborum</i> muscle of suckling and earlyweaned dual-purpose wool/meat lambs

Omega-3 Fatty Acid Effect on Alveolar Bone Loss in Rats

Effects of calorie restriction and ω-3 dietary fat on aging in short-and long-lived rodents

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Role of omega-3 fatty acids in health and disease

Cited by 123 publications

References 48 publications

The fatty acid composition of longissimus &lt;i&gt;lumborum&lt;/i&gt; muscle of suckling and earlyweaned dual-purpose wool/meat lambs

The fatty acid composition of longissimus &lt;i&gt;lumborum&lt;/i&gt; muscle of suckling and earlyweaned dual-purpose wool/meat lambs

Omega-3 Fatty Acid Effect on Alveolar Bone Loss in Rats

Effects of calorie restriction and ω-3 dietary fat on aging in short-and long-lived rodents

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The fatty acid composition of longissimus <i>lumborum</i> muscle of suckling and earlyweaned dual-purpose wool/meat lambs

The fatty acid composition of longissimus <i>lumborum</i> muscle of suckling and earlyweaned dual-purpose wool/meat lambs