Role of Omega-3 Fatty Acids on Lipid  Profile in Diabetic Dyslipidaemia: Single  Blind, Randomised Clinical Trial

Chauhan, Sunita; Kodali, Hanish; Jawad, Noor; Ramteke, Karuna Balwant; Gawai, Vidisha

doi:10.7860/jcdr/2017/20628.9449

Cited by 13 publications

(16 citation statements)

References 22 publications

(4 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although a recent systematic review suggested that omega-3 fatty acids are not useful in the management of established cardiovascular disease, they can be an effective method of risk factor modification [17]. Specifically, omega-3 fatty acids have been shown to have a weak anti-hypertensive effect as well as an ability to reduce triglyceride levels and improve lipid profile [12,17,18]. This may, in part, explain why populations with a high dietary intake of omega-3 fatty acids have low reported levels of cardiovascular disease [19], however, the lipid lowering capacity of dietary intervention is not limited to omega-3 fatty acids.…”

Section: Nutrition In the Prevention Of Endothelial Dysfunction Anmentioning

confidence: 99%

Nutritional Considerations for Peripheral Arterial Disease: A Narrative Review

2019

View full text Add to dashboard Cite

Those with peripheral arterial disease (PAD) require important considerations with respect to food and nutrition, owing to advanced age, poor diet behaviours and immobility associated with the disease process and co-morbid state. These considerations, coupled with the economic effectiveness of medical nutrition therapy, mandate that dietetic care plays a vital role in the management of PAD. Despite this, optimising dietetic care in PAD remains poorly understood. This narrative review considers the role of medical nutrition therapy in every stage of the PAD process, ranging from the onset and initiation of disease to well established and advanced disease. In each case, the potential benefits of traditional and novel medical nutrition therapy are discussed.

show abstract

Section: Nutrition In the Prevention Of Endothelial Dysfunction Anmentioning

confidence: 99%

Nutritional Considerations for Peripheral Arterial Disease: A Narrative Review

2019

View full text Add to dashboard Cite

show abstract

“…It is well established that T2DM is associated with dyslipidemia ( 4) and that n-3 intake has long been indicated in the treatment of hyperlipidemia [30,31]. As cell membrane fatty acids play an important role in signal transduction, and n-3 fatty acids are capable of modifying gene expression, it is thought that the dramatic lipid-altering effects of n-3 fatty acids are mediated via this mechanism [54].…”

Section: Discussionmentioning

confidence: 99%

Effect of n-3 (Omega-3) Polyunsaturated Fatty Acid Supplementation on Metabolic and Inflammatory Biomarkers and Body Weight in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of RCTs

2021

View full text Add to dashboard Cite

Beneficial effects of n-3 fatty acids on metabolic biomarkers in patients with type 2 diabetes (T2DM) has been reported. The objectives of this current research were to investigate the effects of n-3 supplementation on metabolic factors, weight, and body mass index (BMI) in patients with type 2 diabetes mellitus (T2DM), using a meta-analysis of randomized, controlled trials (RCTs). Online databases PubMed, Embase, Web of Science, and Science Direct were searched until 2021 to identify eligible articles. Thirty trials were included. The results showed that n-3 consumption can significantly reduce glycemic factors including fasting blood sugar (FBS) (−0.36 (−0.71 to −0.01)), glycated hemoglobulin (HbA1c) (−0.74 (−1.13 to −0.35)), and homeostatic model assessment of insulin resistance (HOMA.IR) (−0.58 (−1.13 to −0.03)). Furthermore, significant improvement in lipid profile including triglycerides (TG) (−0.27 (−0.37 to −0.18)), total cholesterol (−0.60 (−0.88 to −0.32)), low density lipoprotein (LDL) (−0.54 (−0.85 to −0.23)), and high-density lipoprotein (HDL) (0.60 (0.23 to 0.96)) levels were found in the present meta-analysis. The reduction in the inflammatory marker’s tumor necrosis factor-alpha (TNF-α) (−0.13 (−0.75 to 0.48)) and c-reactive protein (CRP) (−0.72 (−1.70 to 0.27)), as well as weight (−0.09 (−0.24 to 0.07)) and BMI (−0.13 (−0.29 to 0.02)) were not statistically significant. Furthermore, the findings revealed that the optimal dose and duration of n-3 consumption for patients with T2DM is 1000–2000 mg/d for more than 8 weeks. The present meta-analysis and review reveals that n-3 supplementation can improve glycemic factors and lipid profile in patients with T2DM. Furthermore, n-3 supplementation may provide beneficial effects on inflammatory markers and body weight if used at the appropriate dose and duration.

show abstract

“…Omega-3 PUFAs are reported to be associated with a range of general health benefits that include reducing the risk of cardiovascular disease, 38 39 lowering systemic triglycerides 40 and improving clinical symptoms of dry eye disease. 44 In animal models of experimental peripheral nerve injury, increasing endogenous levels of omega-3 PUFAs have been shown to improve sciatic blood flow and accelerate the recovery of neuronal function.…”

Section: Discussionmentioning

confidence: 99%

“… 37 Increased consumption of omega-3 PUFAs is considered to provide a range of potential general health benefits, including a reduced risk of cardiovascular disease 38 39 and lowered systemic triglycerides. 40 DHA, as an integral component in cellular membrane structures of the brain and retina, has been implicated in perinatal visual and neural development. 41–43 In ocular conditions, omega-3 fatty acids supplements can reduce the symptoms and clinical signs associated with ocular surface inflammation in dry eye disease.…”

Section: Introductionmentioning

confidence: 99%

Omega-3 polyunsaturated fatty acid supplementation for improving peripheral nerve health: protocol for a systematic review

et al. 2018

View full text Add to dashboard Cite

IntroductionDamage to peripheral nerves occurs in a variety of health conditions. Preserving nerve integrity, to prevent progressive nerve damage, remains a clinical challenge. Omega-3 polyunsaturated fatty acids (PUFAs) are implicated in the development and maintenance of healthy nerves and may be beneficial for promoting peripheral nerve health. The aim of this systematic review is to assess the effects of oral omega-3 PUFA supplementation on peripheral nerve integrity, including both subjective and objective measures of peripheral nerve structure and/or function.Methods and analysisA systematic review of randomised controlled trials that have evaluated the effects of omega-3 PUFA supplementation on peripheral nerve assessments will be conducted. Comprehensive electronic database searches will be performed in Ovid MEDLINE, Embase, the Cochrane Central Register of Controlled Trials (CENTRAL), US National Institutes of Health Clinical Trials Registry and the WHO International Clinical Trials Registry Platform. The title, abstract and keywords of identified articles will be assessed for eligibility by two reviewers. Full-text articles will be obtained for all studies judged as eligible or potentially eligible; these studies will be independently assessed by two reviewers to determine eligibility. Disagreements will be resolved by consensus. Risk of bias assessment will be performed using the Cochrane Collaboration risk of bias tool to appraise the quality of included studies. If clinically meaningful, and there are a sufficient number of eligible studies, a meta-analysis will be conducted and a summary of findings table will be provided.Ethics and disseminationThis is a systematic review that will involve the analysis of previously published data, and therefore ethics approval is not required. A manuscript reporting the results of this systematic review will be published in a peer-reviewed journal and may also be presented at relevant scientific conferences.PROSPERO registration number CRD42018086297.

show abstract

Role of Omega-3 Fatty Acids on Lipid Profile in Diabetic Dyslipidaemia: Single Blind, Randomised Clinical Trial

Cited by 13 publications

References 22 publications

Nutritional Considerations for Peripheral Arterial Disease: A Narrative Review

Nutritional Considerations for Peripheral Arterial Disease: A Narrative Review

Effect of n-3 (Omega-3) Polyunsaturated Fatty Acid Supplementation on Metabolic and Inflammatory Biomarkers and Body Weight in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of RCTs

Omega-3 polyunsaturated fatty acid supplementation for improving peripheral nerve health: protocol for a systematic review

Contact Info

Product

Resources

About