Role of Ocimum basilicum L. in prevention of ischemia and reperfusion-induced cerebral damage, and motor dysfunctions in mice brain

Bora, Kundan Singh; Arora, Shruti; Shri, Richa

doi:10.1016/j.jep.2011.07.066

Cited by 84 publications

(54 citation statements)

References 44 publications

(41 reference statements)

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“…Cerebral ischemia is reported to impair motor coordination and balance [23]. In the present study, Rotarod test was used to investigate the effect of cerebral ischemia and reperfusion on motor function.…”

Section: Discussionmentioning

confidence: 96%

Neuroprotective Effect of Matricaria chamomilla Extract on Motor Dysfunction Induced by Transient Global Cerebral Ischemia and Reperfusion in Rat

Moshfegh

Setorki

2017

Zahedan J Res Med Sci

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Section: Discussionmentioning

confidence: 96%

Neuroprotective Effect of Matricaria chamomilla Extract on Motor Dysfunction Induced by Transient Global Cerebral Ischemia and Reperfusion in Rat

Moshfegh

Setorki

2017

Zahedan J Res Med Sci

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“…O. basilicum are being used traditionally for the treatment of gastrointestinal disorders [2,3], diabetes [22], headaches, cardiovascular and neurodegenerative disorders [23], and as anti-inflammatory [24]. An endothelium-dependant vasorelaxant and anti-platelet aggregation activities of an aqueous extract from O. basilicum have also been reported [25].…”

Section: Disscussionmentioning

confidence: 99%

Phytochemical screening and evaluation of cardioprotective activity of ethanolic extract of Ocimum basilicum L. (basil) against isoproterenol induced myocardial infarction in rats

et al. 2012

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Background and the purpose of the studyThe objectives of the present study were phytochemical screening and study of the effects of ethanolic extract of aerial parts of Ocimum basilicum (basil) on cardiac functions and histopathological changes in isoproterenol-induced myocardial infarction (MI).MethodsThe leaves of the plant were extracted with ethanol by maceration and subjected to colorimetry to determine flavonoids and phenolic compounds. High-performance TLC analysis and subsequent CAMAG's TLC scanning were performed to quantify rosmarinic acid content. Wistar rats were assigned to 6 groups of normal control, sham, isoproterenol, and treatment with 10, 20, and 40 mg/kg of the extract two times per day concurrent with MI induction. A subcutaneous injection of isoproterenol (100 mg/kg/day) for 2 consecutive days was used to induce MI.ResultsPhytochemical screening indicated the presence of phenolic compounds (5.36%) and flavonoids (1.86%). Rosmarinic acid was the principal phenolic compound with a 15.74% existence. The ST-segment elevation induced by isoproterenol was significantly suppressed by all doses of the extract. A severe myocardial necrosis and fibrosis with a sharp reduction in left ventricular contractility and a marked increase in left ventricular end-diastolic pressure were seen in the isoproterenol group, all of which were significantly improved by the extract treatment. In addition to in-vitro antioxidant activity, the extract significantly suppressed the elevation of malondialdehyde levels both in the serum and the myocardium.ConclusionThe results of the study demonstrate that Ocimum basilicum strongly protected the myocardium against isoproterenol-induced infarction and suggest that the cardioprotective effects could be related to antioxidative activities.

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“…These plants have neuroprotective effect. 6,7,8,9 However, their anti-Alzheimer potential is not explored comprehensively.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Two Culinary Plant Species for Anticholinesterase, Antioxidant and Cytotoxic Activity

Kaur¹,

Shri²

2018

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Introduction: Alzheimer's disease (AD) is a neurodegenerative disorder that markedly affects the cognitive functions. Although drugs are available for symptomatic relief, complete cure is yet to be achieved. Herbals are being explored for their anti-Alzheimer potential and some are excellent obstructers for pathological hallmarks of the disease. In this context we have investigated anticholinesterase, antioxidant and cytotoxic potential of the two culinary plant species Allium cepa and Ocimum basilicum. Materials and Methods: Hydro-methanol extracts of both plants were prepared by maceration. The extracts were standardized with respect to phenolic and flavonoid content. DPPH radical scavenging and ferric reducing assays were employed for antioxidant evaluation. Anticholinesterase prospective was evaluated using Ellman method. The cytotoxic effect of extracts on C6 glioma cells was examined by MTT assay. Results: Both the plant extracts displayed significant antioxidant activity in DPPH assay (IC 50 value of A. cepa 30.10±6.96 µg/ml and O. basilicum 38.67±1.72µg/ml). Reducing ability was comparatively high for A. cepa. In the Ellman assay, A. cepa was determined to be a good acetylcholinesterase inhibitor (IC 50 value: 51.78±1.05 µg/ml). Both the extracts were found to be non-toxic in MTT assay below the concentration of 100 µg/ml. The A. cepa extract had higher phenolic and flavonoid content. Conclusion: A. cepa has strong antioxidant and acetylcholinesterase inhibitory effect and can be considered an excellent candidate for developing as a drug for management of AD.

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Role of Ocimum basilicum L. in prevention of ischemia and reperfusion-induced cerebral damage, and motor dysfunctions in mice brain

Cited by 84 publications

References 44 publications

Neuroprotective Effect of Matricaria chamomilla Extract on Motor Dysfunction Induced by Transient Global Cerebral Ischemia and Reperfusion in Rat

Neuroprotective Effect of Matricaria chamomilla Extract on Motor Dysfunction Induced by Transient Global Cerebral Ischemia and Reperfusion in Rat

Phytochemical screening and evaluation of cardioprotective activity of ethanolic extract of Ocimum basilicum L. (basil) against isoproterenol induced myocardial infarction in rats

Evaluation of Two Culinary Plant Species for Anticholinesterase, Antioxidant and Cytotoxic Activity

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