Role of obesity on cerebral hemodynamics and cardiorespiratory responses in healthy men during repetitive incremental lifting

Cavuoto, Lora; Maikala, Rammohan V.

doi:10.1007/s00421-015-3171-3

Cited by 9 publications

(10 citation statements)

References 60 publications

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“…Similarly, hematological factors and inter‐individual variability in NIRS could have also influenced our results in our obese subjects during recovery. Our results agree with previously studies reporting similar cerebral hemodynamics after exercise in obese subjects versus nonobese controls (Cavuoto and Maikala , ). Other studies have reported a reduced cerebral hemodynamics during recovery in cardiac patients (Koike et al.…”

Section: Discussionsupporting

confidence: 93%

“…), but this effect was not found in our HF‐OB group. Another study showed a reduced cerebral oxygenation (measured by NIRS) in young obese adults during repetitive incremental lifting to exhaustion as compared to nonobese controls (Cavuoto and Maikala ). Therefore, aging (Fisher et al.…”

Section: Discussionmentioning

confidence: 95%

“…Similarly to the cardiovascular function, very few studies are reported on the impact of obesity on cerebral hemodynamics during exercise and recovery, and none were performed in older obese adults. Conflicting results on cerebral hemodynamics during exercise were recently reported in young obese men versus AMHC (Cavuoto and Maikala , ). One study reported a similar cerebral oxygenation‐perfusion (measured by near‐infra red spectroscopy: NIRS) during submaximal cycling exercise in young obese men versus AMHC (Cavuoto and Maikala ), while the same authors showed a reduced cerebral oxygenation (measured by NIRS) during repetitive incremental lifting to exhaustion in a similar cohort (Cavuoto and Maikala ).…”

Section: Introductionmentioning

confidence: 93%

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Cardiovascular and cerebral hemodynamics during exercise and recovery in obese individuals as a function of their fitness status

et al. 2017

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The aim of this study was to compare cardiovascular hemodynamics and cerebral oxygenation/perfusion (COP) during and after maximal incremental exercise in obese individuals according to their aerobic fitness versus age‐matched healthy controls (AMHC). Fifty‐four middle–aged obese (OB) and 16 AMHC were recruited. Maximal cardiopulmonary function (gas exchange analysis), cardiac hemodynamics (impedance cardiography), and left frontal COP (near‐infrared spectroscopy: NIRS) were measured continuously during a maximal incremental ergocycle test. During recovery, reoxygenation/perfusion rate (ROPR: oxyhemoglobin: ΔO2Hb, deoxyhemoglobin: ΔHHb and total hemoglobin: ΔtHb; with NIRS) was also measured. Obese participants (OB, n = 54) were divided into two groups according to the median V˙O2 peak: the low‐fit obese (LF‐OB, n = 27) and the high‐fit obese (HF‐OB, n = 27). During exercise, end tidal pressure of CO 2 (PETCO 2), and COP (ΔO2Hb, ΔHHb and ΔtHb) did not differ between groups (OB, LF‐OB, HF‐OB, AMHC). During recovery, PETCO 2 and ROPR (ΔO2Hb, ΔHHb and ΔtHb) were similar between the groups (OB, LF‐OB, HF‐OB, AMHC). During exercise and recovery, cardiac index was lower (P < 0.05) in LF‐OB versus the other two groups (HF‐OB, AMHC). As well, systolic blood pressure was higher during exercise in the OB, LF‐OB and HF‐OB groups versus AMHC (P < 0.05). When compared to AMHC, obese individuals (OB, LF‐OB, HF‐OB) have a similar cerebral vasoreactivity by CO 2 and cerebral hemodynamics during exercise and recovery, but a higher systolic blood pressure during exercise. Higher fitness in obese subjects (HF‐OB) seems to preserve their cardiopulmonary and cardiac function during exercise and recovery.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 93%

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Cardiovascular and cerebral hemodynamics during exercise and recovery in obese individuals as a function of their fitness status

et al. 2017

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“…Participants were instrumented with two NIRS sensors (NIRO 300, Hamamatsu Photonics, Japan) on their forehead to continuously measure cerebral hemodynamic responses. Each optical sensor set consisted of an emitter and detector spaced 4 cm apart, and was placed over the left and right prefrontal cortex region, approximately 3 cm from the midline of the forehead and just above the supraorbital ridge [ 7 ]. Dark elastic bandage was wrapped around the NIRS sensors for light shielding.…”

Section: Methodsmentioning

confidence: 99%

“…At the cerebral level, oxygenation, measured by near-infrared spectroscopy (NIRS), is affected by the level of exercise intensity [ 6 ]. For example, Cavuoto and Maikala [ 7 ] demonstrated that acute exposure to repetitive lifting exercise decreases cardiorespiratory responses and cerebral hemodynamics in individuals who are obese, contributing to their reduced lifting capacity. An inverse correlation between BMI and prefrontal cortex metabolic activity during cognitive function was demonstrated using brain imaging, suggesting reduced cerebral blood flow in overweight individuals [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Obesity and the Role of Short Duration Submaximal Work on Cardiovascular and Cerebral Hemodynamics

Cavuoto

Maikala

2016

PLoS ONE

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The objective of this study was to compare gas exchange, cardiac and cerebral hemodynamic responses between 10 non-obese and 10 obese men during submaximal work. With the increasing prevalence of obesity, there is a need to understand the impact of obesity on work-induced responses. Participants completed a step-wise incremental cycling until they reached 60% of their age-predicted maximum heart rate. Gas exchange, cardiac and pre-frontal cortex hemodynamic responses were simultaneously measured during rest, work, and recovery. The non-obese group reached ~43% of their predicted maximal aerobic capacity as compared to ~34% in the obese group, with the non-obese working at a relatively higher workload and for more duration than the obese. The obese had elevated baseline heart rate and reduced whole-body oxygen uptake per body weight at baseline and task termination. Other cardiac and cerebral responses, although increased from baseline, were similar between groups during submaximal effort. In the obese, during recovery oxygen uptake and heart-rate recovery were slowest; cardiac output and rate pressure product were greatest, and left ventricle ejection time was shortest. However, both groups exhibited similar cerebral hemodynamics during recovery. These finding imply that, irrespective of their low aerobic fitness, obesity does not impair myocardial performance and cerebrovascular function during graded submaximal work, however, recovery from a short duration of work was influenced by their fitness level. Since a majority of activities of daily living are performed at individual’s submaximal level, understanding influence of obesity on submaximal work is critical.

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Metabolic Syndrome, Hormones, and Exercise

Δίπλα

Zafeiridis

Tordjman

2020

Endocrinology of Physical Activity and Sport

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Role of obesity on cerebral hemodynamics and cardiorespiratory responses in healthy men during repetitive incremental lifting

Abstract: These findings suggest that acute exposure to repetitive lifting exercise decreases cardiorespiratory responses and cerebral hemodynamics in the group who are obese, which may contribute to their reduced lifting capacity.

Cited by 9 publications

References 60 publications

Cardiovascular and cerebral hemodynamics during exercise and recovery in obese individuals as a function of their fitness status

Cardiovascular and cerebral hemodynamics during exercise and recovery in obese individuals as a function of their fitness status

Obesity and the Role of Short Duration Submaximal Work on Cardiovascular and Cerebral Hemodynamics

Metabolic Syndrome, Hormones, and Exercise

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