Metabolic Syndrome, Hormones, and Exercise

Δίπλα, Κωνσταντίνα; Zafeiridis, Andreas; Tordjman, Karen

doi:10.1007/978-3-030-33376-8_29

Cited by 1 publication

(1 citation statement)

References 146 publications

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“…In addition to insulin administration and an adequate diet, supporting therapies such as physical exercise are employed to reduce hyperglycemia during pregnancy. In general, the benefits of regular exercise lead to better perinatal outcomes (Melzer, Schutz, Boulvain, & Kayser, 2010), less risk of developing cardiovascular disease and cancer (Martinez‐Gomez et al, 2019), better vascular micro and macro endothelial function and angiogenesis (Dipla, Zafeiridis, & Tordjman, 2020), improved health of beta‐pancreatic cells (Curran et al, 2020), blood pressure control and dyslipidemia, improved glucose uptake by skeletal muscles and promoted mitochondrial biogenesis and a better quality of life (Dipla et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Maternal‐fetal outcomes of exercise applied in rats with mild hyperglycemia after embryonic implantation

Soares

Moraes-Souza

Carneiro

et al. 2020

Birth Defects Research

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Background Exercise is commonly recommended to control hyperglycemia, including during pregnancy. We conducted this study to understand the potential benefits and risks of exercise during pregnancy of women with diabetes. Specifically, we evaluated the effects of swimming on a diabetic rat during pregnancy and assayed maternal‐fetal parameters. Methods Diabetes was induced in the female newborn from Wistar rats by the streptozotocin administration on first postnatal day. At 110 days of life, after confirm mild symptoms of diabetes, the rats were mated and randomly distributed into four experimental groups (minimum of 13 animals/group): Control (C)—nondiabetic animals without swimming; Control and Exercise (CEx)—nondiabetic animals submitted to swimming; Mild Diabetic (MD)—diabetic animals without swimming; Mild Diabetic and Exercise (MDEx)—diabetic animals submitted to swimming. The swimming program was performed from day 7 to 21 of pregnancy. Maternal parameters were evaluated during the pregnancy period. On day 21 of pregnancy, the rats were sacrificed and maternal and fetal parameters analyzed. Results There are no alterations in body weight, food consumption, water intake, and reproductive outcomes among the groups. The swimming program did not normalize maternal glycemia and other biochemical biomarkers. The diabetes and exercise combination increased organ weight. The fetuses born to these exercising diabetic rats had reduced fetal weight and increased skeletal anomalies (mainly incomplete ossification of sternebra). Conclusion The intense swimming exercise imposed on female rats during pregnancy impaired maternal metabolic repercussions, contributing to intrauterine growth restriction and fetal skeletal anomalies.

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