Role of nutritional vitamin D in osteoporosis treatment

Hou, Yi‐Chou; Wu, Chia-Chao; Liao, Min-Tser; Shyu, Jia‐Fwu; Hung, Chi‐Feng; Yen, Tzung‐Hai; Lu, Cheng Wei; Lu, Kuo‐Cheng

doi:10.1016/j.cca.2018.05.035

Cited by 43 publications

(32 citation statements)

References 174 publications

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“…However, researches have shown that osteoblast-lineage cells are not only involved in bone formation, but are also involved in bone resorption supporting the differentiation and activation of osteoclasts [ 47 ]. Imbalance between bone formation and bone resorption may cause some bone related deformities, like osteoporosis [ 48 ].…”

Section: Native Bone Structure and Compositionmentioning

confidence: 99%

A Review on Properties of Natural and Synthetic Based Electrospun Fibrous Materials for Bone Tissue Engineering

2018

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Bone tissue engineering is an interdisciplinary field where the principles of engineering are applied on bone-related biochemical reactions. Scaffolds, cells, growth factors, and their interrelation in microenvironment are the major concerns in bone tissue engineering. Among many alternatives, electrospinning is a promising and versatile technique that is used to fabricate polymer fibrous scaffolds for bone tissue engineering applications. Copolymerization and polymer blending is a promising strategic way in purpose of getting synergistic and additive effect achieved from either polymer. In this review, we summarize the basic chemistry of bone, principle of electrospinning, and polymers that are used in bone tissue engineering. Particular attention will be given on biomechanical properties and biological activities of these electrospun fibers. This review will cover the fundamental basis of cell adhesion, differentiation, and proliferation of the electrospun fibers in bone tissue scaffolds. In the last section, we offer the current development and future perspectives on the use of electrospun mats in bone tissue engineering.

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Section: Native Bone Structure and Compositionmentioning

confidence: 99%

A Review on Properties of Natural and Synthetic Based Electrospun Fibrous Materials for Bone Tissue Engineering

2018

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“…Zwiększona aktywność RANKL nad OPG prowadzi do dominacji procesów osteolitycznych. Natomiast przeciwnie zwiększona aktywność OPG prowadzi do osteopetrozy (nadmierne kostnienie), stymuluje kościotworzenie i aktywność osteoblastów [28,29].…”

Section: Wpływ Witaminy D Na Układ Kostnyunclassified

“…Witamina D wywiera bezpośredni efekt na przebudowę kości przez swój receptor (VDR) i jego odmiany polimorficzne [31,32,34,35]. Identyfikacja i rozpoznanie odmian genu VDR powiązanych z niską BMD daje możliwość wczesnego wykrycia ryzyka wystąpienia osteoporozy lub indywidualnej predyspozycji do jej rozwoju [25,29]. Pozwala na wdrożenie profilaktyki zapobiegającej jej występowaniu lub opóźnieniu ujawnienia.…”

Section: Wpływ Polimorfizmów Genu Receptora Witaminy D (Vdr) Na Układunclassified

“…Ma to istotne znaczenie, gdyż pierwszy okres tego schorzenia jest zwykle bezobjawowy. Problem najczęściej dotyczy kobiet w okresie pomenopauzalnym, ponieważ pierwotna i wtórna niedoczynność gonad i hiperprolaktynemia drastycznie zwiększają ryzyko występowania osteoporozy [25,29]. Ważne byłoby jednak wcześniejsze określenie predyspozycji genetycznych, co mogłoby umożliwić zastosowanie działań profilaktycznych.…”

Section: Wpływ Polimorfizmów Genu Receptora Witaminy D (Vdr) Na Układunclassified

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The impact of VDR gene polymorphisms on obesity, metabolic changes, bone mass disorders and neoplastic processes

Wysoczańska-Klaczyńska

Ślęzak

Hetman

et al. 2018

Pediatr Endocrino Diabetes Metab

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“…Listed in the next section is a summary of current nonpharmacologic and nonsurgical treatments for osteoporosis. Nutritional support, such as adequate calcium and vitamin D, as well as exercise are among the crucial cornerstones of the prevention of osteoporosis and are necessary during treatment with pharmacologic agents [1,[11][12][13][14]. However, current evidence has shown that routine calcium and vitamin D supplements in healthy individuals are not needed.…”

Section: Introductionmentioning

confidence: 99%

Nutritional Support and Physical Modalities for People with Osteoporosis: Current Opinion

2019

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Osteoporosis is a vital healthcare issue among elderly people. During the aging process, a gradual loss of bone mass results in osteopenia and osteoporosis. Heritable factors account for 60–80% of optimal bone mineralization, whereas modifiable factors such as nutrition, weight-bearing exercise, body mass, and hormonal milieu affect the development of osteopenia and osteoporosis in adulthood. Osteoporosis substantially increases the risk of skeletal fractures and further morbidity and mortality. The effective prevention of fractures by reducing the loss of bone mass is the primary goal for physicians treating people with osteoporosis. Other than pharmacologic agents, lifestyle adjustment, nutritional support, fall prevention strategies, exercise, and physical modalities can be used to treat osteoporosis or prevent further osteoporotic fracture. Each of these factors, alone or in combination, can be of benefit to people with osteoporosis and should be implemented following a detailed discussion with patients. This review comprises a systematic survey of the current literature on osteoporosis and its nonpharmacologic and nonsurgical treatment. It provides clinicians and healthcare workers with evidence-based information on the assessment and management of osteoporosis. However, numerous issues regarding osteoporosis and its treatment remain unexplored and warrant future investigation.

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Role of nutritional vitamin D in osteoporosis treatment

Cited by 43 publications

References 174 publications

A Review on Properties of Natural and Synthetic Based Electrospun Fibrous Materials for Bone Tissue Engineering

A Review on Properties of Natural and Synthetic Based Electrospun Fibrous Materials for Bone Tissue Engineering

The impact of VDR gene polymorphisms on obesity, metabolic changes, bone mass disorders and neoplastic processes

Nutritional Support and Physical Modalities for People with Osteoporosis: Current Opinion

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