Role of Nutritional Support under Clinical Nursing Path on the Efficacy, Quality of Life, and Nutritional Status of Elderly Patients with Alzheimer’s Disease

H, Wu; Wen, Ya; Guo, Saijin

doi:10.1155/2022/9712330

Cited by 4 publications

(4 citation statements)

References 19 publications

(11 reference statements)

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“…Protein-calorie malnutrition is strongly correlated with patients with cognitive decline and AD ( Doorduijn et al, 2019 ). Wu et al (2022) found that adequate nutritional support can significantly improve the quality of life, cognitive function, and psychological and nutritional status of elderly AD patients. Furthermore, nutritional support was associated with better sleep quality as measured by the Pittsburgh Sleep Quality Index (PSQI) ( Wu et al, 2022 ).…”

Section: Resultsmentioning

confidence: 99%

Effect of nutrition in Alzheimer’s disease: A systematic review

2023

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Background and objectiveAlzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by declining cognitive ability. Currently, there are no effective treatments for this condition. However, certain measures, such as nutritional interventions, can slow disease progression. Therefore, the objective of this systematic review was to identify and map the updates of the last 5 years regarding the nutritional status and nutritional interventions associated with AD patients.Study designA systematic review.MethodsA search was conducted for randomized clinical trials, systematic reviews, and meta-analyses investigating the association between nutritional interventions and AD published between 2018 and 2022 in the PubMed, Web of Science, Scopus, and Cochrane Library databases. A total of 38 studies were identified, of which 17 were randomized clinical trials, and 21 were systematic reviews and/or meta-analyses.ResultsThe results show that the western diet pattern is a risk factor for developing AD. In contrast, the Mediterranean diet, ketogenic diet, and supplementation with omega-3 fatty acids and probiotics are protective factors. This effect is significant only in cases of mild-to-moderate AD.ConclusionCertain nutritional interventions may slow the progression of AD and improve cognitive function and quality of life. Further research is required to draw more definitive conclusions.

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Section: Resultsmentioning

confidence: 99%

Effect of nutrition in Alzheimer’s disease: A systematic review

2023

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“…The VAS score is considered a global measure of health status [ 48 ] 1 [ 74 ] WHOQoL-BREF General 26-items HRQoL scale consisting of four domains (physical health, psychological, social, and environmental). Each domain is scored on a 5-point scale from 0 to 100, with higher scores indicating better QoL [ 75 ] 6 [ 76 – 81 ] PedsQoL General Instrument for assessing patients and parents’ perceptions of HRQoL in pediatric patients with chronic health conditions. Consists of a 15-item core measure of global HRQoL AND eight supplemental modules assessing specific symptoms or treatment domains [ 82 ] 2 [ 83 , 84 ] AQoL-8D General QoL questionnaire based in AQoL-6D questionnaire which adds explicit dimensions for self-worth and happiness and expands the items in mental health [ 85 – 87 ] 2 [ 88 , 89 ] AQoL-6D General QoL questionnaire based in AQoL-4D questionnaire were.…”

Section: Resultsmentioning

confidence: 99%

How quality of life is measured in studies of nutritional intervention: a systematic review

Pemau,

González-Palacios,

Kerr

2024

Health Qual Life Outcomes

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Background Nutrition care can positively affect multiple aspects of patient’s health; outcomes are commonly evaluated on the basis of their impact on a patient’s (i) illness-specific conditions and (ii) health-related quality of life (HRQoL). Our systematic review examined how HRQoL was measured in studies of nutritional interventions. To help future researchers select appropriate Quality of Life Questionnaires (QoLQ), we identified commonly-used instruments and their uses across populations in different regions, of different ages, and with different diseases. Methods We searched EMCare, EMBASE, and Medline databases for studies that had HRQoL and nutrition intervention terms in the title, the abstract, or the MeSH term classifications “quality of life” and any of “nutrition therapy”, “diet therapy”, or “dietary supplements” and identified 1,113 studies for possible inclusion.We then reviewed titles, abstracts, and full texts to identify studies for final inclusion. Results Our review of titles, abstracts, and full texts resulted in the inclusion of 116 relevant studies in our final analysis. Our review identified 14 general and 25 disease-specific QoLQ. The most-used general QoLQ were the Short-Form 36-Item Health Survey (SF-36) in 27 studies and EuroQol 5-Dimension, (EQ-5D) in 26 studies. The European Organization for Research and Treatment of Cancer Quality of life Questionnaire (EORTC-QLQ), a cancer-specific QoLQ, was the most frequently used disease-specific QoLQ (28 studies). Disease-specific QoLQ were also identified for nutrition-related diseases such as diabetes, obesity, and dysphagia. Sixteen studies used multiple QoLQ, of which eight studies included both general and disease-specific measures of HRQoL. The most studied diseases were cancer (36 studies) and malnutrition (24 studies). There were few studies focused on specific age-group populations, with only 38 studies (33%) focused on adults 65 years and older and only 4 studies focused on pediatric patients. Regional variation in QoLQ use was observed, with EQ-5D used more frequently in Europe and SF-36 more commonly used in North America. Conclusions Use of QoLQ to measure HRQoL is well established in the literature; both general and disease-specific instruments are now available for use. We advise further studies to examine potential benefits of using both general and disease-specific QoLQ to better understand the impact of nutritional interventions on HRQoL.

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“…Protein-calorie shortage is linked to cognitive decline and AD. Quality of life, cognitive function, and psychological and nutritional condition were all found to be considerably improved with sufficient dietary care for senior AD patients by Wu et al (13). Improved sleep quality, as measured by the Pittsburgh Sleep Quality Index (PSQI), was also linked to dietary supplementation (13,14).…”

Section: Diet and Nutritionmentioning

confidence: 99%

Alzheimer’s disease: the role of extrinsic factors in its development, an investigation of the environmental enigma

Suresh,

Singh S,

Rushendran

et al. 2023

Front. Neurol.

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In the realm of Alzheimer’s disease, the most prevalent form of dementia, the impact of environmental factors has ignited intense curiosity due to its substantial burden on global health. Recent investigations have unveiled these environmental factors as key contributors, shedding new light on their profound influence. Notably, emerging evidence highlights the detrimental role of various environmental contaminants in the incidence and progression of Alzheimer’s disease. These contaminants encompass a broad spectrum, including air pollutants laden with ozone, neurotoxic metals like lead, aluminum, manganese, and cadmium, pesticides with their insidious effects, and the ubiquitous presence of plastics and microplastics. By meticulously delving into the intricate web connecting environmental pollutants and this devastating neurological disorder, this comprehensive chapter takes a deep dive into their involvement as significant risk factors for Alzheimer’s disease. Furthermore, it explores the underlying molecular mechanisms through which these contaminants exert their influence, aiming to unravel the complex interactions that drive the pathogenesis of the disease. Additionally, this chapter proposes potential strategies to mitigate the detrimental effects of these environmental contaminants on brain health, with the ultimate goal of restoring and preserving typical cognitive function. Through this comprehensive exploration, we aim to enhance our understanding of the multifaceted relationship between neurotoxins and Alzheimer’s disease, providing a solid foundation for developing innovative in-vivo models and advancing our knowledge of the intricate pathological processes underlying this debilitating condition.

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Role of Nutritional Support under Clinical Nursing Path on the Efficacy, Quality of Life, and Nutritional Status of Elderly Patients with Alzheimer’s Disease

Cited by 4 publications

References 19 publications

Effect of nutrition in Alzheimer’s disease: A systematic review

Effect of nutrition in Alzheimer’s disease: A systematic review

How quality of life is measured in studies of nutritional intervention: a systematic review

Alzheimer’s disease: the role of extrinsic factors in its development, an investigation of the environmental enigma

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