Role of Nutraceuticals in COVID-19 Mediated Liver Dysfunction

Sikander, Mohammed; Malik, Shabnam; Rodriguez, Anyssa; Yallapu, Murali M.; Narula, Acharan S.; Dhevan, Vijian; Chauhan, Subhash C.; Jaggi, Meena

doi:10.3390/molecules25245905

Cited by 12 publications

(8 citation statements)

References 154 publications

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“…Available studies suggest that MD exerts protective effects on the expression of several proatherogenic genes, resulting in modulation of vascular inflammation, thrombosis, and foam-cell formation[ 32 - 34 ]. In this sense, legumes, for which we demonstrated that patients with lower CV risk have a higher adherence, contain a lot of phytochemicals endowed with useful biological activities[ 35 , 36 ]. Phytochemicals were shown to have prominent antioxidant activity, improve endothelial function by increasing nitric oxide bioavailability and prevent atherosclerosis progression by inhibition of low-density lipoprotein oxidation[ 37 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

Adherence to Mediterranean diet and advanced glycation endproducts in patients with diabetes

Grahovac¹,

Kumrić²,

Vilović³

et al. 2021

WJD

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BACKGROUND In recent years, American Diabetes Association started to strongly advocate the Mediterranean diet (MD) over other diets in patients with diabetes mellitus (DM) because of its beneficial effects on glycemic control and cardiovascular (CV) risk factors. Tissue levels of advanced glycation endproducts (AGEs) emerged as an indicator of CV risk in DM. Skin biopsy being invasive, the use of AGE Reader has been shown to reflect tissue AGEs reliably. AIM To examine the association between adherence to MD and AGEs in patients with DM type II. METHODS This cross-sectional study was conducted on 273 patients with DM type II. A survey questionnaire was composed of 3 separate sections. The first part of the questionnaire included general data and the habits of the participants. The second part aimed to assess the basic parameters of participants’ diseases and associated conditions. The third part of the questionnaire was the Croatian version of the 14-item MD service score (MDSS). AGEs levels and associated CV risk were measured using AGE Reader (DiagnOptics Technologies BV, Groningen, The Netherlands). RESULTS A total of 27 (9.9%) patients fulfilled criteria for adherence to MD, with a median score of 8.0 (6.0-10.0). Patients with none/limited CV risk had significantly higher percentage of MD adherence in comparison to patients with increased/definite CV risk (15.2% vs 6.9%, P = 0.028), as well as better adherence to guidelines for nuts (23.2% vs 12.6%, P = 0.023) and legumes (40.4% vs 25.9%, P = 0.013) consumption. Higher number of patients with glycated hemoglobin (HbA1c) < 7% adhered to MD when compared to patients with HbA1c > 7% (14.9% vs 7.3%, P = 0.045). Moreover, those patients followed the MDSS guidelines for eggs (33.0% vs 46.8%, P = 0.025) and wine (15.6% vs 29.8%, P = 0.006) consumption more frequently. MDSS score had significant positive correlation with disease duration ( r = 0.179, P = 0.003) and negative correlation with body mass index (BMI) values ( r = -0.159, P = 0.008). In the multiple linear regression model, BMI (β ± SE, -0.09 ± 0.04, P = 0.037) and disease duration (β ± SE, 0.07 ± 0.02, P < 0.001) remained significant independent correlates of the MDSS score. Patients with HbA1c > 7% think that educational programs on nutrition would be useful for patients in significantly more cases than patients with HbA1c < 7% (98.9% vs 92.6%, P = 0.009). ...

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Section: Discussionmentioning

confidence: 99%

Adherence to Mediterranean diet and advanced glycation endproducts in patients with diabetes

Grahovac¹,

Kumrić²,

Vilović³

et al. 2021

WJD

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“…Lupin, salvia, garlic, and EVOO have anti-oxidant, anti-inflammatory, or antiviral properties and can recover the expression of ACE2 on the cell membrane, otherwise suppressed by SARS-CoV-2 binding and entry into the cytoplasm. Sikander et al [ 6 ] provided information and summarized the effects of natural bioactive antiviral, immunomodulatory, and hepatoprotective nutraceuticals ( Silybum marianum , Solanum nigrum , Cichorium intybus , Allium sativum , Glycyrrhiza glabra , Phyllanthus amarus , Withania somnifera , Curcuma longa , and other hepatoprotective agents) that might be explored in managing COVID-19-induced liver dysfunction. Additionally, omega-3 long-chain polyunsaturated fatty acids (omega-3 LC-PUFAs) might also have effects on different stages of viral infection, including virus entry and replication, and help improve the inflammatory balance.…”

Section: Nutrition Therapy For Covid-19-related Liver Dysfunctionmentioning

confidence: 99%

COVID-19 and liver dysfunction: What nutritionists need to know

Wang¹,

Yu²,

Zhou³

et al. 2022

WJG

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The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus-2 has brought serious challenges for the medical field. Patients with COVID-19 usually have respiratory symptoms. However, liver dysfunction is not an uncommon presentation. Additionally, the degree of liver dysfunction is associated with the severity and prognosis of COVID-19. Prevention, diagnosis, and treatment of malnutrition should be routinely recommended in the management of patients with COVID-19, especially in those with liver dysfunction. Recently, a large number of studies have reported that nutrition therapy measures, including natural dietary supplements, vitamins, minerals and trace elements, and probiotics, might have potential hepatoprotective effects against COVID-19-related liver dysfunction via their antioxidant, antiviral, anti-inflammatory, and positive immunomodulatory effects. This review mainly focuses on the possible relationship between COVID-19 and liver dysfunction, nutritional and metabolic characteristics, nutritional status assessment, and nutrition therapy to provide a reference for the nutritionists while making evidence-based nutritional decisions during the COVID-19 pandemic.

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“…Curcuma longa and Solanum Nigrum being hepato-protective, have been exploited as nutraceutical sources ( Sikander et al, 2020 ). Synergistic responses of combined nutraceuticals are also being studied, such as curcumin combined with quercetin and nobiletin metabolite, which shows enhanced anticancer effects ( DiMarco-Crook et al, 2020 ; Sharma et al, 2019 ).…”

Section: The Contemporary Global Market Of Nutraceuticalsmentioning

confidence: 99%