Role of nonpancreatic lipolytic activity in exocrine pancreatic insufficiency

Abrams, Cynthia K.; Hamosh, Margit; Dutta, Sudhir K.; Hubbard, Van S.; Hamosh, Paul

doi:10.1016/0016-5085(87)90848-1

Cited by 92 publications

(42 citation statements)

References 27 publications

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“…Dietary fat can, the preduodenal lipases, i.e. lingual lipase and gastric lipase [1,[3][4][5]. The relative activities of these lipases depend on the species ob served [6].…”

Section: Introductionmentioning

confidence: 99%

Intestinal Absorption of Octanoic, Decanoic, and Linoleic Acids: Effect of Triglyceride Structure

Jensen¹,

Christensen²,

Høy³

1994

Ann Nutr Metab

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The influence of triglyceride structure on the intestinal absorption of specific triglycerides was investigated. A bolus of either a structured or a randomized oil was given to lymph-cannulated rats. The structured oil contained medium-chain fatty acids (MCFA) in the sn-1 and sn-3 position of the triglyceride, and linoleic acid (C18:2 n-6) in the sn-2 position, whereas in the randomized oil the same fatty acids were distributed randomly between the three positions. The absorption of MCFA was highest from the randomized oil, where approximately 33% of the MCFA were located in the sn-2 position. The absorption of C18:2 n-6 was highest from the structured oil, where C 18:2 n-6 is located in the sn-2 position, indicating that the intestinal absorption is influenced by triglyceride structure, and that the absorption is enhanced for fatty acids located in the sn-2 position. Prior to lymph collection, the rats were fed either a fish oil or a vegetable oil diet. The absorption of C18:2 n-6 was highest in the rats previously fed the fish oil diet. The incorporation of the highly unsaturated fatty acids from the fish oil into the membrane phospholipids may thus influence the absorption of fat.

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“…Dietary fat can, the preduodenal lipases, i.e. lingual lipase and gastric lipase [1,[3][4][5]. The relative activities of these lipases depend on the species ob served [6].…”

Section: Introductionmentioning

confidence: 99%

Intestinal Absorption of Octanoic, Decanoic, and Linoleic Acids: Effect of Triglyceride Structure

Jensen¹,

Christensen²,

Høy³

1994

Ann Nutr Metab

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show abstract

“…Due to the presence of salivary amylase, carbohydrate malabsorption appears not to be an important problem. By contrast, although the existence of a gastric protease (pepsin), protein malabsorption with creatorrhea induces a loss of amino acids and energy; even more important is the lipid malabsorption which is only partly compensated by the gastric lipase secretion [41] and thus induces steatorrhea. The lipid malabsorption is one of the key problems of exocrine pancreatic insufficiency: lipase is the first enzyme secretion to be decreased in the course of the disease.…”

Section: Enzyme Substitutionmentioning

confidence: 99%

Postoperative pain therapy following operation for chronic pancreatitis

Renou

Laugier

2001

Pancreatology

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“…Accordingly, patients with exocrine pancreatic insufficiency may absorb more than 50% of dietary fat despite the absence of measurable pancreatic lipase activity. Abrams et al [7] found that pancreatic insufficiency was associated with significantly higher nonpancreatic lipolytic activity in the duodenum under fasting conditions. However, no significant difference between the groups tested was found in postprandial nonpancreatic lipolytic activity.…”

Section: Definition Of Exocrine Pancreatic Insufficiencymentioning

confidence: 99%

Appropriate pancreatic function tests and indication for pancreatic enzyme therapy following surgical procedures on the pancreas

Lankisch

2001

Pancreatology

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Role of nonpancreatic lipolytic activity in exocrine pancreatic insufficiency

Cited by 92 publications

References 27 publications

Intestinal Absorption of Octanoic, Decanoic, and Linoleic Acids: Effect of Triglyceride Structure

Intestinal Absorption of Octanoic, Decanoic, and Linoleic Acids: Effect of Triglyceride Structure

Postoperative pain therapy following operation for chronic pancreatitis

Appropriate pancreatic function tests and indication for pancreatic enzyme therapy following surgical procedures on the pancreas

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