Role of nitric oxide in focal microcirculation disorder of guinea pig cochlea

Nagura, Mitsuyoshi; Iwasaki, Satoshi; Mizuta, Kunihiro; Mineta, Hiroyuki; Umemura, Kazuo; Hoshino, Tomoyuki

doi:10.1016/s0378-5955(00)00250-1

Cited by 9 publications

(4 citation statements)

References 45 publications

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“…NO donors increase (and inhibitors decrease) blood flow in the cochlear and vestibular arteries (6,35,71,124) and the spiral modiolar artery (131,278). NO also plays a key role in maintaining cochlear blood flow under pathological conditions, such as focal cochlear microcirculation disorder (211). Nonspecific NOS activators increase blood flow in the spiral modiolar artery, and inhibitors decrease it, primarily through actions at the level of the precapillary arteriole (116,117).…”

Section: Cgmp and Cochlear Blood Flowmentioning

confidence: 99%

Genetics of guanylyl cyclase pathways in the cochlea and their influence on hearing

Fitzakerley

Trachte

2018

Physiological Genomics

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Although hearing loss is the most common sensory deficit in Western societies, there are no successful pharmacological treatments for this disorder. Recent experiments have demonstrated that manipulation of intracellular cyclic guanosine monophosphate (cGMP) concentrations can have both beneficial and harmful effects on hearing. In this review, we will examine the role of cGMP as a key second messenger involved in many aspects of cochlear function and discuss the known functions of downstream effectors of cGMP in sound processing. The nitric oxide-stimulated soluble guanylyl cyclase system (sGC) and the two natriuretic peptide-stimulated particulate GCs (pGCs) will be more extensively covered because they have been studied most thoroughly. The cochlear GC systems are attractive targets for medical interventions that improve hearing while simultaneously representing an under investigated source of sensorineural hearing loss.

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Section: Cgmp and Cochlear Blood Flowmentioning

confidence: 99%

Genetics of guanylyl cyclase pathways in the cochlea and their influence on hearing

Fitzakerley

Trachte

2018

Physiological Genomics

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“…The mechanisms of trauma to inner-ear structures during use of lasers were considered to be: thermal load to tissue structures; acoustic load; direct irradiation and damage to the sensory cells; and inner-ear toxicity from products resulting from thermal effects. 10 Our research assumed that the higher immunoactivity of Hsp70, induced by thermal damage and inflammation following CO 2 laser irradiation, was a possible mechanism of cochlear trauma. Concurrent production of large amounts of NO, indicated by intense iNOS immunostaining, may also be an important factor in cochlear injury.…”

Section: Discussionmentioning

confidence: 92%

“…(iNOS, NOSII) (usually not expressed constitutively but inducible under pathological conditions, e. g. endolymphatic hydrops, inflammation, adminstration of anticancer drugs or noise exposure). [9][10][11][12][13][14] These reports suggested that large amounts of NO are associated with various pathological conditions of the inner ear.…”

mentioning

confidence: 99%

Influence of carbon dioxide laser irradiation on the morphology and function of guinea pig cochlea

et al. 2005

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Both experimental and clinical studies have demonstrated that carbon dioxide laser is suitable for stapedotomy. The aim of this study was to investigate morphological, electrophysiological and functional changes in the inner ear after irradiation with CO(2) laser set with different energy parameters. A cochleostomy in the basal cochlear turn of guinea pig cochleae was performed with CO(2) laser of 1, 2 and 3 w, respectively. The cochleae were removed three weeks after laser irradiation. The auditory evoked brainstem response (ABR) was measured before and after laser application and immediately before removal of the cochlea. Immunohistochemical methods were used to examine inducible nitric oxide synthase (iNOS/NOSII) and heat-shock protein 70 (Hsp70) concentrations in the cochlea after laser application. The organ of Corti was studied by scanning electron microscopy. Worse hearing loss was observed in animals receiving higher-power CO(2) laser. These findings correlated with more intense injury of the cochlear ultrastructure and with positive expression of iNOS and Hsp70 in spiral ganglion cells, nerve fibres, supporting cells of the organ of Corti and cells of the spiral ligament. The CO(2) laser as a noncontact procedure is shown to be effective and safe if the total amount of energy is kept within the limits applied in this study. Nitric oxide and stress proteins play important roles in the traumatic mechanism of the inner ear, which are related to hearing loss and injury of the ultrastructure of the inner ear.

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“…Because NO can act as a double‐edged sword, 13,18–21 it may play different roles in generating overall noise‐induced cochlear dysfunction and destruction. The role of peroxynitrite overproduction, as well as the relationship between NO and peroxynitrite overproduction in noise‐induced threshold shift, needs further study.…”

Section: Discussionmentioning

confidence: 99%

Chronologic Changes of Nitric Oxide Concentration in the Cochlear Lateral Wall and Its Role in Noise‐Induced Permanent Threshold Shift

et al. 2008

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Noise-induced threshold shift, which resolved to a mild PTS, can be partially attributed to NO elevation in the cochlear lateral wall. Our results revealed a nonlinear correlation between ABR recovery and depletion of NO, indicating that the mechanisms of NO changes in the cochlear lateral wall may be more complicated than previously conceived and that other pathophysiologic mechanisms may also play important roles in noise-induced PTS.

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Role of nitric oxide in focal microcirculation disorder of guinea pig cochlea

Cited by 9 publications

References 45 publications

Genetics of guanylyl cyclase pathways in the cochlea and their influence on hearing

Genetics of guanylyl cyclase pathways in the cochlea and their influence on hearing

Influence of carbon dioxide laser irradiation on the morphology and function of guinea pig cochlea

Chronologic Changes of Nitric Oxide Concentration in the Cochlear Lateral Wall and Its Role in Noise‐Induced Permanent Threshold Shift

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