Role of NCoR1 in mitochondrial function and energy metabolism

Abstract

Mitochondrial number and shape are constantly changing in response to increased energy demands. The ability to synchronize mitochondrial pathways to respond to energy fluctuations within the cell is a central aspect of mammalian homeostasis. This dynamic process depends on the coordinated activation of transcriptional complexes to promote the expression of genes encoding for mitochondrial proteins. Recent evidence has shown that the nuclear corepressor NCoR1 is an essential metabolic switch which acts on oxidative metabolism signaling. Here, we provide an overview of the emerging role of NCoR1 in the transcriptional control of energy metabolism. The identification and characterization of NCoR1 as a central, evolutionary conserved player in mitochondrial function have revealed a novel layer of metabolic control. Defining the precise mechanisms by which NCoR1 acts on energy homeostasis will ultimately contribute towards the development of novel therapies for the treatment of metabolic diseases such as obesity and type 2 diabetes.

The ion channels and transporters gene expression profile indicates a shift in excitability and metabolisms during malignant progression of Follicular Lymphoma

“…In agreement, oxidative enzymes ( ACAD10 , ACAD8 , ECHS1 , HADHB ) turned out to be over expressed (log2FC > 0) in DLBCL (Supplementary Table S7). Consistently, the nuclear corepressor-encoding gene NCoR1 , whose down-regulation has been reported to drive the switch towards oxidative metabolism 38 , results under expressed in DLBCL (Supplementary Table S8). In agreement with our data, an OxPhos subset of DLBCL, identified by a lower expression of NCoR1 , has been recently described in 39,40 .…”

Identification of novel blood-based HCC-specific diagnostic biomarkers for human hepatocellular carcinoma

“…Nuclear Receptor Corepressor 1(NCOR1) protein was detected in the cytoplasm and nucleus of secretory epithelial cells in the normal prostate and prostate cancer metastasis showed an obvious decline in NCOR1 transcriptional output [35,36]. Recent evidence showed that NCOR1 is an essential metabolic switch which acts on oxidative metabolism signaling and may play a distinct role in liver regeneration and hepatocarcinogenesis in mice [37,38]. As one of the hub genes, the mRNA expression of NCOR1 in HCC tissue sample was explored and decreased expression of it is associated with short survival time.…”

HOS15 is a transcriptional corepressor of NPR1-mediated gene activation of plant immunity

“…NCoR1 and SMRT mediate transcriptional repression by recruiting a multiprotein complex including HDAC3, TBL1 and its homolog TBL-related 1 (TBLR1), and a G-protein pathway suppressor (GPS2) (17,19). NCoR1 is required for cellular function in many biological processes, including metabolism, development, and glucocorticoid receptor signaling (32)(33)(34)(35). Unexpectedly, NCoR1 is also a transcriptional activator of certain retinoic acid response elements (26).…”