Role of Nanostructuring on the Properties of Oxide Materials: The Case of Zirconia Nanoparticles

Pacchioni, Gianfranco

doi:10.1002/ejic.201801314

Cited by 11 publications

(6 citation statements)

References 63 publications

(169 reference statements)

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“…(Continued) Although ZrO 2 is not traditionally considered to be a reducible metal oxide near physiological conditions (although this point has been called into question in a recent publication and may be significantly dependent on surface character, nanostructuring [85] ), it has been shown to have the ability to interact with peroxide and generate a set of reactive oxygen species, including • OH, O 2− , and O 2 2− , in quantities comparable to those produced by conventional Fenton-type oxides. Without ZrO 2 directly interacting, an electron transfer happens between the H 2 O 2 and HO 2− groups through an outer sphere-type reaction.…”

Section: Enzyme-mimetic Reactivities and Ph-dependent Activity Of Red...mentioning

confidence: 99%

Surface Chemistry of Biologically Active Reducible Oxide Nanozymes

et al. 2023

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Reducible metal oxide nanozymes (rNZs) have been a subject of intense recent interest due to their catalytic nature, ease of synthesis, and complex surface character. Such materials contain surface sites which facilitate enzyme‐mimetic reactions via substrate coordination and redox cycling. Further, these surface reactive sites have been shown to be highly sensitive to stresses within the nanomaterial lattice, the physicochemical environment, and to processing conditions occurring as part of their syntheses. When administered in vivo, a complex protein corona binds to the surface, redefining its biological identity and subsequent interactions within the biological system. Catalytic activities of rNZs each deliver a differing impact on protein corona formation, its composition, and in turn, their recognition, and internalization by host cells. Improving our understanding of the precise principles that dominate rNZ surface‐biomolecule adsorption raises the question of whether designer rNZs can be engineered to prevent corona formation, or indeed to produce “custom” protein coronas applied either in vitro, and pre‐administration, or formed immediately upon their exposure to body fluids. Here, we consider fundamental surface chemistry processes and their implications in rNZ material performance. In particular, we discuss material structures which inform component adsorption from the application environment, including substrates for enzyme‐mimetic reactions.This article is protected by copyright. All rights reserved

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Section: Enzyme-mimetic Reactivities and Ph-dependent Activity Of Red...mentioning

confidence: 99%

Surface Chemistry of Biologically Active Reducible Oxide Nanozymes

et al. 2023

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“…Zirconium oxide (ZrO 2 ) is a kind of metallic oxide nanomaterial used in various applications, such as in electrochemical sensors [40]. However, it has a band gap width of approximately 5.0 eV [41], compared to a band gap of only about 2.57 or 2.74 eV for zirconium molybdate (ZrMo 2 O 8 ). Therefore, ZrMo 2 O 8 exhibits excellent photocatalytic properties [42,43].…”

Section: Introductionmentioning

confidence: 99%

Zirconium Molybdate Nanocomposites’ Sensing Platform for the Sensitive and Selective Electrochemical Detection of Adefovir

Xiao

Yao

et al. 2022

Molecules

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Adefovir (ADV) is an anti-retroviral drug, which can be used to treat acquired immune deficiency syndrome (AIDS) and chronic hepatitis B (CHB), so its quantitative analysis is of great significance. In this work, zirconium molybdate (ZrMo2O8) was synthesized by a wet chemical method, and a composite with multi-walled carbon nanotubes (MWCNTs) was made. ZrMo2O8-MWCNTs composite was dropped onto the surface of a glassy carbon electrode (GCE) to prepare ZrMo2O8-MWCNTs/GCE, and ZrMo2O8-MWCNTs/GCE was used in the electrochemical detection of ADV for the first time. The preparation method is fast and simple. The materials were characterized by X-ray powder diffraction (XRD), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS) and cyclic voltammetry (CV). It was electrochemically analysed by differential pulse voltammetry (DPV). Compared with single-material modified electrodes, ZrMo2O8-MWCNTs/GCE showed a vastly improved electrochemical response to ADV. Moreover, the sensor complements the study of the electrochemical detection of ADV. Under optimal conditions, the proposed electrochemical method showed a wide linear range (from 1 to 100 μM) and a low detection limit (0.253 μM). It was successfully tested in serum and urine. In addition, the sensor has the advantages of a simple preparation, fast response, good reproducibility and repeatability. It may be helpful in the potential applications of other substances with similar structures.

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“…Similarly to silica NPs, ZrNPs are subjected to extensive study and functionalization to modify the surface properties of these materials. The surface chemistry on zirconia [10] is not comparable to that of silica in particular due to the decreased chemical stability of the silane bond from Zr−O−Si−R with respect to Si−O−Si−R. In fact, the employment of organosilane chemistry for the functionalization of zirconia provides limited applications [11] .…”

Section: Introductionmentioning

confidence: 99%

Modification of Amorphous Mesoporous Zirconia Nanoparticles with Bisphosphonic Acids: A Straightforward Approach for Tailoring the Surface Properties of the Nanoparticles

Scarso

Hossain

Florean

et al. 2021

Chemistry A European J

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The use of readily prepared bisphosphonic acids obtained in few steps through a thio‐Michael addition of commercially available thiols on tetraethyl vinylidenebisphosphonate enables the straightforward surface modification of amorphous mesoporous zirconia nanoparticles. Simple stirring of the zirconia nanoparticles in a buffered aqueous solution of the proper bisphosphonic acid leads to the surface functionalization of the nanoparticles with different kinds of functional groups, charge and hydrophobic properties. Formation of both chemisorbed and physisorbed layers of the bisphosphonic acid take place, observing after extensive washing a grafting density of 1.1 molecules/nm2 with negligible release in neutral or acidic pH conditions, demonstrating stronger loading compared to monophosphonate derivatives. The modified nanoparticles were characterized by IR, XPS, ζ‐potential analysis to investigate the loading of the bisphosphonic acid, FE‐SEM to investigate the size and morphologies of the nanoparticles and 31P and 1H MAS NMR to investigate the coordination motif of the phosphonate units on the surface. All these analytical techniques demonstrated the strong affinity of the bisphosphonic moiety for the Zr(IV) metal centers. The functionalization with bisphosphonic acids represents a straightforward covalent approach for tailoring the superficial properties of zirconia nanoparticles, much straightforward compared the classic use of trisalkoxysilane or trichlorosilane reagents typically employed for the functionalization of silica and metal oxide nanoparticles. Extension of the use of bisphosphonates to other metal oxide nanoparticles is advisable.

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Role of Nanostructuring on the Properties of Oxide Materials: The Case of Zirconia Nanoparticles

Cited by 11 publications

References 63 publications

Surface Chemistry of Biologically Active Reducible Oxide Nanozymes

Surface Chemistry of Biologically Active Reducible Oxide Nanozymes

Zirconium Molybdate Nanocomposites’ Sensing Platform for the Sensitive and Selective Electrochemical Detection of Adefovir

Modification of Amorphous Mesoporous Zirconia Nanoparticles with Bisphosphonic Acids: A Straightforward Approach for Tailoring the Surface Properties of the Nanoparticles

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