Role of nanocarriers in photodynamic therapy

Qidwai, Afreen; Annu, .; Nabi, Bushra; Narang, Jasjeet Kaur; Baboota, Sanjula; Ali, Javed

doi:10.1016/j.pdpdt.2020.101782

Cited by 35 publications

(23 citation statements)

References 42 publications

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“…In the case of type II reactions, the PS transition into the excited triplet state enables the energy to be transferred directly to the oxygen in the energetic base state (the basic triplet state). Hence, the PDT destroys cancerous cells and vascular damage through photochemical and subsequent oxidation reactions, where the damage caused by the free radicals and ROS presents a short lifetime (10–320 ns) [ 259 , 260 , 261 , 262 , 263 , 264 ]. Table 4 summarizes the polymersomes designed for the controlled release induced by photo-oxidation.…”

Section: Light-responsive Polymersomes For Anticancer Therapeutic Del...mentioning

confidence: 99%

Light-Triggered Polymersome-Based Anticancer Therapeutics Delivery

et al. 2022

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Polymersomes are biomimetic cell membrane-like model structures that are self-assembled stepwise from amphiphilic copolymers. These polymeric (nano)carriers have gained the scientific community’s attention due to their biocompatibility, versatility, and higher stability than liposomes. Their tunable properties, such as composition, size, shape, and surface functional groups, extend encapsulation possibilities to either hydrophilic or hydrophobic cargoes (or both) and their site-specific delivery. Besides, polymersomes can disassemble in response to different stimuli, including light, for controlling the “on-demand” release of cargo that may also respond to light as photosensitizers and plasmonic nanostructures. Thus, polymersomes can be spatiotemporally stimulated by light of a wide wavelength range, whose exogenous response may activate light-stimulable moieties, enhance the drug efficacy, decrease side effects, and, thus, be broadly employed in photoinduced therapy. This review describes current light-responsive polymersomes evaluated for anticancer therapy. It includes light-activable moieties’ features and polymersomes’ composition and release behavior, focusing on recent advances and applications in cancer therapy, current trends, and photosensitive polymersomes’ perspectives.

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Section: Light-responsive Polymersomes For Anticancer Therapeutic Del...mentioning

confidence: 99%

Light-Triggered Polymersome-Based Anticancer Therapeutics Delivery

et al. 2022

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“…Generally, they are divided into inorganic and organic NPs depending on their composition. [ 203,205 ]…”

Section: Nanotechnology and Chlorophyll Derivativesmentioning

confidence: 99%

Light‐Activated Biomedical Applications of Chlorophyll Derivatives

Pucci

Martinelli

Degl’Innocenti

et al. 2021

Macromolecular Bioscience

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Tetrapyrroles are the basis of essential physiological functions in most living organisms. These compounds represent the basic scaffold of porphyrins, chlorophylls, and bacteriochlorophylls, among others. Chlorophyll derivatives, obtained by the natural or artificial degradation of chlorophylls, present unique properties, holding great potential in the scientific and medical fields. Indeed, they can act as cancer‐preventing agents, antimutagens, apoptosis inducers, efficient antioxidants, as well as antimicrobial and immunomodulatory molecules. Moreover, thanks to their peculiar optical properties, they can be exploited as photosensitizers for photodynamic therapy and as vision enhancers. Most of these molecules, however, are highly hydrophobic and poorly soluble in biological fluids, and may display undesired toxicity due to accumulation in healthy tissues. The advent of nanomedicine has prompted the development of nanoparticles acting as carriers for chlorophyll derivatives, facilitating their targeted administration with demonstrated applicability in diagnosis and therapy. In this review, the chemical and physical properties of chlorophyll derivatives that justify their usage in the biomedical field, with particular regard to light‐activated dynamics are described. Their role as antioxidants and photoactive agents are discussed, introducing the most recent nanomedical applications and focusing on inorganic and organic nanocarriers exploited in vitro and in vivo.

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“…Modern nanotechnology methods can overcome this obstacle, yielding nanoparticles with strictly defined properties that can act as carriers for drugs in various therapies, including PDT. 4 , 9 A number of PS nanocarriers has been reported so far, 10 including liposomes, 11 dendrimers 12–15 and polymersomes 16 as well as dendrimersomes. 17–19 …”

Section: Introductionmentioning

confidence: 99%

Triazine–Carbosilane Dendrimersomes Enhance Cellular Uptake and Phototoxic Activity of Rose Bengal in Basal Cell Skin Carcinoma Cells

Sztandera¹,

Gorzkiewicz²,

Bątal³

et al. 2022

IJN

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Background The search for new formulations for photodynamic therapy is intended to improve the outcome of skin cancer treatment using significantly reduced doses of photosensitizer, thereby avoiding side effects. The incorporation of photosensitizers into nanoassemblies is a versatile way to increase the efficiency and specificity of drug delivery into target cells. Herein, we report the loading of rose bengal into vesicle-like constructs of amphiphilic triazine-carbosilane dendrons (dendrimersomes) as well as biophysical and in vitro characterization of this novel nanosystem. Methods Using established protocol and analytical and spectroscopy techniques we were able to synthesized dendrons with strictly designed properties. Engaging biophysical methods (hydrodynamic diameter and zeta potential measurements, analysis of spectral properties, transmission electron microscopy) we confirmed assembling of our nanosystem. A set of in vitro techniques was used for determination ROS generation, (ABDA and H 2 DCFDA probes), cell viability (MTT assay) and cellular uptake (flow cytometry and confocal microscopy). Results Encapsulation of rose bengal inside dendrimersomes enhances cellular uptake, intracellular ROS production and concequently, the phototoxicity of this photosensitizer. Conclusion Triazine-carbosilane dendrimersomes show high capacity as drug carriers for anticancer photodynamic therapy.

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Role of nanocarriers in photodynamic therapy

Cited by 35 publications

References 42 publications

Light-Triggered Polymersome-Based Anticancer Therapeutics Delivery

Light-Triggered Polymersome-Based Anticancer Therapeutics Delivery

Light‐Activated Biomedical Applications of Chlorophyll Derivatives

Triazine–Carbosilane Dendrimersomes Enhance Cellular Uptake and Phototoxic Activity of Rose Bengal in Basal Cell Skin Carcinoma Cells

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