Role of nanocarriers and their surface modification in targeting delivery of bioactive compounds

Rachmawati, Heni; Larasati, Atsarina; Adi, Annis Catur; Shegokar, Ranjita

doi:10.1016/b978-0-12-817778-5.00002-6

Cited by 5 publications

(6 citation statements)

References 120 publications

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“…The optimal coating technique for all lipid-based nanocarriers that allows for improved selectivity cannot be determined . Additionally, for each new ligand-lipid-based nanocarriers development and to prevent the targeted ligands from becoming inactive, the optimization of functionalization approach must be thoroughly examined . Purification of lipid-based nanocarriers following surface functionalization is a key problem to achieve a reliable characterization of functionalized lipid-based nanocarriers.…”

Section: Current Challenges and Future Perspectivesmentioning

confidence: 99%

“…Low concentrations and very short residence time of the drugs at the cellular and target sites are major factors that contribute to the inability to eradicate the disease and the development of multidrug resistance against the therapeutic drugs. 14,15 Nanocarriers can also boost the biodistribution of therapeutics to the target organs and improve pharmacokinetics, which leads to increased efficacy and minimize side effects. 3 Surface-modified lipid-based nanocarriers result in targeted medication delivery because they maintain appropriate therapeutic concentrations at the targeted site for a prolonged time.…”

Section: Surface Modifiers Utilized For Surface Modification Of Lipid...mentioning

confidence: 99%

“… 91 Additionally, for each new ligand-lipid-based nanocarriers development and to prevent the targeted ligands from becoming inactive, the optimization of functionalization approach must be thoroughly examined. 14 Purification of lipid-based nanocarriers following surface functionalization is a key problem to achieve a reliable characterization of functionalized lipid-based nanocarriers. The transdermal lipid-based nanocarriers attain the active drug targeting delivery capacity within chosen particular ligands for target receptors, which results in its enhanced therapeutic applicability.…”

Section: Current Challenges and Future Perspectivesmentioning

confidence: 99%

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Surface Modification of Lipid-Based Nanocarriers: A Potential Approach to Enhance Targeted Drug Delivery

2022

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Nanocarriers have the utmost significance for advancements in drug delivery and nanomedicine technology. They are classified as polymer-based nanocarriers, lipid-based nanocarriers, viral nanoparticles, or inorganic nanoparticles, depending on their constituent parts. Lipid-based nanocarrier systems have gained tremendous attention over the years because of their noteworthy properties like high drug-loading capacity, lower toxicity, better bioavailability and biocompatibility, stability in the gastrointestinal tract, controlled release, simpler scale-up, and validation process. Nanocarriers still have some disadvantages like poor drug penetration, limited drug encapsulation, and poor targeting. These disadvantages can be overcome by their surface modification. Surface-modified nanocarriers result in controlled release, enhanced penetration efficiency, and targeted medication delivery. In this review, the authors summarize the numerous lipidbased nanocarriers and their functionalization through various surface modifiers such as polymers, ligands, surfactants, and fatty acids. Recent examples of newly developing surface-modified lipid-based nanocarrier systems from the available literature, along with their applications, have been compiled in this work.

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Section: Current Challenges and Future Perspectivesmentioning

confidence: 99%

Section: Surface Modifiers Utilized For Surface Modification Of Lipid...mentioning

confidence: 99%

Section: Current Challenges and Future Perspectivesmentioning

confidence: 99%

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Surface Modification of Lipid-Based Nanocarriers: A Potential Approach to Enhance Targeted Drug Delivery

2022

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“…Many bioactive compounds possess limited solubility in water, bioavailability, and reduced stability 17 . Nowadays, this is still a challenge for pharma industry and new drug developments.…”

Section: Introductionmentioning

confidence: 99%

“…[14][15][16] Many bioactive compounds possess limited solubility in water, bioavailability, and reduced stability. 17 Nowadays, this is still a challenge for pharma industry and new drug developments. For example, caffeic acid phenethyl ester (CAPE), also known as phenylethyl caffeate or phenethyl caffeate is a natural bioactive substance which has overabundance of important pharmacological and biological activities such as antioxidant, antiviral, antiallergic, antimicrobial, anti-inflammatory, immunomodulatory, and anticancer effect.…”

Section: Introductionmentioning

confidence: 99%

Poly(ethylene oxide)‐block‐poly(α‐cinnamyl‐ε‐caprolactone‐co‐ε‐caprolactone) diblock copolymer nanocarriers for enhanced solubilization of caffeic acid phenethyl ester

Atanasova

Grancharov

Petrov

2020

Journal of Polymer Science

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We report novel micellar carriers, comprising pendant cinnamyl moieties in the core-forming block, designed to increase the solubilization of caffeic acid phenethyl ester (CAPE) in aqueous media. Amphiphilic poly(ethylene oxide)block-poly(α-cinnamyl-ε-caprolactone-co-ε-caprolactone) (PEO-b-P(CyCL-co-CL) diblock copolymers were synthesized by ring-opening copolymerization of α-propargyl-ε-caprolactone and ε-caprolactone from a monofunctional PEO macroinitiator and subsequent attachment of cinnamyl groups via click reaction. In addition, a linear PEO-b-PCL diblock copolymer was synthesized and used in this study for comparison. Next, nanosized micelles from PEO-b-P (CyCL-co-CL) and PEO-b-PCL were formed via the solvent evaporation method and then loaded with CAPE. Dynamic and electrophoretic light scattering, and transmission electron microscopy were used to characterize both blank and loaded carriers. The potential of the micelles comprising pendant cinnamyl group to solubilize CAPE in water was evaluated in a comparative fashion to that of nonmodified PEO-b-PCL diblock copolymer.

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Osteoblast Viability of Liquid Smoke Rice Hull and Nanoparticles Form as Periodontitis Treatment

et al. 2022

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Objective Rice husk liquid smoke nanoparticles have the potential to be developed as a drug because they have anti-inflammatory effects that can modulate the process of osteoblast stimulation through osteoblast stimulation by thorough small size and enter cells easily. The osteoblast is the key of alveolar regeneration in periodontitis treatment. This present study analyzed the differences of liquid smoke rice husk and nanoparticles of liquid smoke rice husk on osteoblast viability as periodontitis treatment Materials and Methods The liquid smoke rice husk was obtained from the pyrolysis process. The nanoparticles were made with chitosan, maltodextrin, and difference of concentration of liquid smoke rice husk (such as 1, 2.5, 5, 7.5, 10, 12.5, 15, and 17.5%). The viability of osteoblast was analyzed by 2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. Statistical Analysis The data were analyzed using independent t-test to analyze the differences between liquid smoke rice husk and nanoparticles of liquid smoke rice husk, the significant was set a p<0.05. Result The nanoparticles of liquid smoke rice husk showed higher osteoblast viability compared liquid smoke rice husk. The nanoparticles' concentration of 5, 7.5, and 10% showed higher osteoblast viability compared liquid smoke rice husk (p = 0.002, 0.000, and 0.001, respectively). Conclusion The nanoparticles of liquid smoke rice husk showed higher viability of osteoblast. This confirmed that the nanoparticles were able to reduce the toxicity in the higher concentration of liquid smoke of rice husk.

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Role of nanocarriers and their surface modification in targeting delivery of bioactive compounds

Cited by 5 publications

References 120 publications

Surface Modification of Lipid-Based Nanocarriers: A Potential Approach to Enhance Targeted Drug Delivery

Surface Modification of Lipid-Based Nanocarriers: A Potential Approach to Enhance Targeted Drug Delivery

Poly(ethylene oxide)‐block‐poly(α‐cinnamyl‐ε‐caprolactone‐co‐ε‐caprolactone) diblock copolymer nanocarriers for enhanced solubilization of caffeic acid phenethyl ester

Osteoblast Viability of Liquid Smoke Rice Hull and Nanoparticles Form as Periodontitis Treatment

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