Role of N-acetylcysteine in rifampicin-induced hepatic injury of young rats

Rana, S. V. S.; Attri, Savita Verma; Vaiphei, Kim; Pal, Ravinder; Attri, Arun K.; Singh, Kartar

doi:10.3748/wjg.v12.i2.287

Cited by 33 publications

(31 citation statements)

References 27 publications

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“…Anti-tuberculosis drugs may have also damaged mitochondria, an intracellular organelle that produces energy, whose dysfunction releases excessive amount of oxidants which in turn injures hepatic cells (Shah, 1999). Studies have indicated the existence of a strong correlation between hepatic injury and oxidative stress in experimental animals treated with anti-tuberculosis drugs Rana et al, 2006). Other studies have shown that anti-tuberculosis drugs generally act as inducers of hepatic cytochrome P 450 enzymes (Trevor et al, 2004;Vuilleumier et al, 2006).…”

Section: Resultsmentioning

confidence: 99%

Effect of homogenates of avocado pear (Persea americana) seeds and fluted pumpkin (Telfairia occidentalis) leaves coadministered with anti-tuberculosis drugs on liver enzymes of albino rats

Jibril¹,

Oluchi²,

Kabara³

et al. 2016

Bayero J. Pure App. Sci.

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This study evaluated the effects of aqueous homogenates of avocado pear (Persea americana) seeds and fluted pumpkin (Telfairia occidentalis) leaves co-administered with anti-tuberculosis drug on liver enzymes of albino rats. Twenty (20) albino rats were divided into five (5) groups (of four rats each) designated as I, II, III, IV and V (which is the normal control). A dose of 5.14mg/kg body weight of a first line anti-tuberculosis drug (a combination of isoniazid, rifampicin, pyrazinamide and ethambutol) was administered orally to two (2) rats in group I, II, III, and IV for seven (7) days and the remaining two rats in each group for fourteen (14) days. The homogenates of avocado pear seeds (at a dose of 250mg/kg body weight), fluted pumpkin leaves (at a dose of 250mg/kg BW) and a mixture of avocado pear seeds and fluted pumpkin leaves (at a dose of 250mg/kg BW, and 125mg/kg BW respectively) were co-administered with the anti-TB drug to groups II, III and IV respectively. Group I rats served as the positive control (i.e. treated with only 5.14mg/kg BW of anti-TB drug). The results indicated that the activities of serum AST, ALT and ALP were significantly higher (P<0.05) in rats administered with 5.14 mg/kg BW first line anti-TB drugs only when compared with that of the rats co-administered with the same anti-TB drug and 250mg/kg BW plant homogenates (avocado pear seeds, fluted pumpkin leave, and a combination of the two homogenates). The mean serum AST, ALT and ALP activities were found to have decrease (P<0.05) in groups II, III, and IV rats from the beginning to the end of the treatment periods. Similarly, mean serum activities of AST, ALT and ALP in group III rats decreased (P<0.05) significantly when compared with that of group II rats. Moreover, the serum activities of these enzymes were significantly lower (P<0.05) in group V rats compared to that of groups II and III rats. The rise in the mean serum activities of liver enzymes in group I rats when compared to that of group V rats indicated that the anti-TB drug is hepatotoxic. The findings of this research work predicts that the aqueous homogenates of both avocado pear seeds and fluted pumpkin leaves have hepatoprotective abilities but, the combination of these plant parts shows more hepatoprotective function (i. e. exhibits synergy).

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Section: Resultsmentioning

confidence: 99%

Effect of homogenates of avocado pear (Persea americana) seeds and fluted pumpkin (Telfairia occidentalis) leaves coadministered with anti-tuberculosis drugs on liver enzymes of albino rats

Jibril¹,

Oluchi²,

Kabara³

et al. 2016

Bayero J. Pure App. Sci.

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“…The plasma half life of AcHz (metabolite of INH) is shortened by RMP and AcHz is quickly converted to its active metabolite by increasing the oxidative elimination rate of AcHz, which is related to the higher incidence of liver necrosis caused by INH and RMP in combination (Hussain et al, 2003). Rats have been used successfully to investigate INH and RIF-induced hepatotoxicity models (Tasduq et al, 2005;Pal et al, 2006;Victorrajmohan et al, 2005;Rana et al, 2006). Therefore, we selected rats to study the hepatotoxic effect of antitubercular drugs and hepatoprotective action of H. corymbosa.…”

Section: Resultsmentioning

confidence: 99%

Hepatoprotective Activity of Hedyotis corymbosa (Linn.) Lam. Extract Against Anti-Tubercular Drug Induced Hepatic Damage in Sprague-Dawley Rats

Lina¹,

Ashab

Bhuiya

et al. 2018

Bangla Pharma J

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The aim of this study was to investigate the protective actions of hydroalcoholic extract of Hedyotis corymbosa against hepatotoxicity caused by different combinations of anti-tubercular drugs. Antitubercular drugs isoniazid and rifampicin were used to make the elevated level of ALT, AST, ALP and bilirubin as well as decreased level of albumin and total protein. Hepatoprotective activity of the plant was indicated when it causes the decrease of these marker enzymes and elevated level of albumin and total protein. H. corymbosa prevented liver damage caused by anti-tubercular drugs and also from histopathological changes. It can be concluded from the above experiment that hydroalcoholic extract of H. corymbosa showed significant hepatoprotective activity against antitubercular drugs.

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“…[109][110][111] Anti-tubercular drugs also induce hypercholesterolemia that might be due to increased uptake of LDL from the blood, by the tissues. [112,113] Hepatitis has been reported to occur 0.46% of individuals undergoing anti-tubercular therapy and receiving anti-tubercular drugs. The rate of hepatotoxic reaction was much higher in Indian patients as compared to that reported from developed countries.…”

Section: World Journal Of Pharmacy and Pharmaceutical Sciencesmentioning

confidence: 99%

A Review on Drug Induced Hepatotoxicity and Its Management by Herbal Drugs

Singh¹

2017

WJPPS

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The liver plays vital functions in maintaining, performing and regulating the homeostasis of body and it involves in almost all biochemical pathways such as nutrient supply, reproduction, biotransformation, energy supply and growth. The liver metabolize, detoxify and activate exogenous as well as endogenous compound and is capable for transforming foreign chemicals as it has high level of enzymatic system. Liver disorder or injury is defined as conditions, diseases, or infections that influence the structure and/or function of

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Role of N-acetylcysteine in rifampicin-induced hepatic injury of young rats

Abstract: NAC protects young rats against RMP-induced oxidative hepatic injury.

Cited by 33 publications

References 27 publications

Effect of homogenates of avocado pear (<i>Persea americana</i>) seeds and fluted pumpkin (<i>Telfairia occidentalis</i>) leaves coadministered with anti-tuberculosis drugs on liver enzymes of albino rats

Effect of homogenates of avocado pear (<i>Persea americana</i>) seeds and fluted pumpkin (<i>Telfairia occidentalis</i>) leaves coadministered with anti-tuberculosis drugs on liver enzymes of albino rats

Hepatoprotective Activity of Hedyotis corymbosa (Linn.) Lam. Extract Against Anti-Tubercular Drug Induced Hepatic Damage in Sprague-Dawley Rats

A Review on Drug Induced Hepatotoxicity and Its Management by Herbal Drugs

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