Hepatoprotective Activity of Hedyotis corymbosa (Linn.) Lam. Extract Against Anti-Tubercular Drug Induced Hepatic Damage in Sprague-Dawley Rats

Lina, Shah Marzia Mahjabin; Ashab, Imran; Bhuiya, M Salahuddin; Shahriar, Mohammad

doi:10.3329/bpj.v21i2.37924

Cited by 7 publications

(4 citation statements)

References 19 publications

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“…In a previous work was described some plant species and some polyherbal preparations from medicinal plants that shown an important HPP activity against the HPT caused by INH/RIF/ PZA and a mixture of them [27,[29][30][31][32][33][34]. In order to update the information on this subject, in this manuscript we describe important additional data.…”

Section: Resultsmentioning

confidence: 99%

Hepato-Protective Effect from Natural Compounds, Biological Products and Medicinal Plant Extracts on Antitubercular Drug-Induced Liver Injuries: A Systematic Review

Ramírez-Marroquín¹,

Jiménez-Arellanes²

2019

Med Aromat Plants

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Tuberculosis is mainly treated with rifampicin, pyrazinamide, isoniazide, ethambutol and/or streptomycin; however, the first three cause hepato-and nephro-toxicity, then the patient abandons therapy. This cause contributes to the failure of the treatment and favors the appearance of drug-resistant strains. Currently, alternatives are being sought to counteract this hepatic-damage, and medicinal plants, natural compounds and/or biological products are of great interest. In this manuscript we describe current data on the hepato-protective effect from extracts of medicinal plants, compounds isolated from them and biological products that protect against liver damage caused by antitubercular (anti-TB) drugs caused by therapy in patients with tuberculosis (TB). The main consulted databases were: PubMed, Worldwidescience.org, and Scopus, including records between 2000 and 2018 years. Thus, we found many articles about hepatoprotective effect from medicinal plants and polyherbal preparations (Hepatoplus and Liv 52), the majority of these have an important effect (on preclinical study) due to their antioxidant compounds content. In addition, the hepatoprotective activity of biological products and/or natural compounds has been discussed and it should be noted that the quercetin (natural antioxidant compound)/ polyvinylpyrrolidone mixture protects against hepatic damage caused by therapy in patients with TB. Another interesting compound with good effect in TB patients is N-acetylcysteine (an oral marketed mucolytic drug) which could be repurposed as an hepatoprotective drug. We consider that these findings are of great interest for researchers and clinicians, also for the development of new agents as well as for the therapeutic use of hepatoprotective substances in patients with TB, which helps reduce the toxic effects that drugs cause.

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Section: Resultsmentioning

confidence: 99%

Hepato-Protective Effect from Natural Compounds, Biological Products and Medicinal Plant Extracts on Antitubercular Drug-Induced Liver Injuries: A Systematic Review

Ramírez-Marroquín¹,

Jiménez-Arellanes²

2019

Med Aromat Plants

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“…The extract was able to lower serum levels of ALT, AST, ALP, and bilirubin while increasing albumin levels. 42 The extract contains many beneficial phytochemicals, including β-sitosterol, lupeol, flavonoid, and stigmasterol. 42…”

Section: Asteracantha Longifoliamentioning

confidence: 99%

Traditional Medicinal Plants with Significant Protection Against Antitubercular Drug-induced Liver Injury: A Systematic Review

Ugwu,

Suru

2023

Future Integr Med

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Background and objectives: Tuberculosis remains a global health concern, and its treatment usually involves potent first-line antitubercular drugs which are tempered by the risk of associated hepatotoxicity leading to noncompliance and drug resistance. In this review, medicinal plants with the potential of protection against antitubercular drug-induced hepatotoxicity in animal models were explored from scientific literature. Methods:From literature published between 1999 and 2022, this review systematically extracted 68 studies that reported on medicinal plants with protection against antitubercular drug-induced liver toxicity in animal models.Results: Isoniazid, pyrazinamide, rifampicin, and ethambutol were the first-line drugs reported in the reviewed studies. The liver enzymes, antioxidant status, inflammatory markers, and improvement in the liver architecture were the criteria most frequently used by the reported studies to access hepatoprotection. These plants are rich in bioactive phytochemicals which exhibit their hepatoprotective properties via mechanisms such as antioxidant activity, anti-inflammatory effects, and detoxification enhancement. Conclusions:This review provides the hepatoprotective properties and mode of action of medicinal plants and encourages future perspectives marked by rigorous scientific research, clinical trials, and integrative medicine approaches. Albeit the challenges of standardization of herbal formulation, safety concerns and hurdles of the regulatory framework must be addressed as traditional medicinal plants offer a promise to mitigate antitubercular drug hepatotoxicity.

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“…Reactive oxygen species (ROS) also contributes to the production of the TGFβ pro-fibrogenic mediator from Kupffer cells and the circulating inflammatory cells and activates hepatic stellate cells directly, which triggers fibrosis (63). In addition to protecting the liver against anticancer drugs, medicinal plants and plant compounds can also protect the liver against other drugs (64,65) and toxic substances (66-69) by exerting their antioxidant activity. These natural treatments can also exert anticancer effects themselves by inducing growth arrest and triggering pro-apoptotic death in liver cells (70).…”

Section: Mechanisms Of Hepatoprotective and Antihepatotoxicity Properties Of Medicinal Herbsmentioning

confidence: 99%

Phytotherapy: An anti-hepatotoxicity and hepatoprotective approach in chemotherapy

et al. 2019

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Chemotherapy induced-hepatotoxicity is one of the prevalent problems among cancer patients, with a wide spectrum of complications from liver dysfunction to liver necrosis. Therefore, in this study, we review the research findings on the effects of medicinal herbs and herbal compounds on the hepatotoxicity induced by anticancer drugs. The words hepatotoxicity and hepatoprotective along with the words cancer drug or chemotherapy in combination with some herbal terms such as medicinal plant, phyto* and herb* were used to search for relevant publications indexed in the Institute for Scientific Information (ISI) and PubMed. Available evidence shows that certain medicinal plants and herbal derivatives can reduce cancer drug-induced hepatotoxicity and protect liver cells against complications by regulating hepatic enzymes and increasing antioxidant enzyme activities. Some herbal formulations, including traditional Chinese medicine, have also been reported to exhibit such effects. Medicinal plants can exert anti-hepatotoxicity effects mainly by increasing antioxidant activity, inhibiting inflammatory processes, and reducing cell necrosis induced by anti-cancer drugs. Phytotherapy can be used as an effective complementary treatment for anticancer drug-induced hepatotoxicity and prevent various complications in the liver.

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Hepatoprotective Activity of Hedyotis corymbosa (Linn.) Lam. Extract Against Anti-Tubercular Drug Induced Hepatic Damage in Sprague-Dawley Rats

Cited by 7 publications

References 19 publications

Hepato-Protective Effect from Natural Compounds, Biological Products and Medicinal Plant Extracts on Antitubercular Drug-Induced Liver Injuries: A Systematic Review

Hepato-Protective Effect from Natural Compounds, Biological Products and Medicinal Plant Extracts on Antitubercular Drug-Induced Liver Injuries: A Systematic Review

Traditional Medicinal Plants with Significant Protection Against Antitubercular Drug-induced Liver Injury: A Systematic Review

Phytotherapy: An anti-hepatotoxicity and hepatoprotective approach in chemotherapy

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