Role of miRNAs in prostate cancer: Do we really know everything?

Cochetti, Giovanni; Vermandois, J.A. Rossi De; Maulà, Vincenza; Giulietti, Matteo; Cecati, Monia; Zingaro, Michele Del; Cagnani, Rosy; Suvieri, Chiara; Paladini, Alessio; Mearini, Ettore

doi:10.1016/j.urolonc.2020.03.007

Cited by 36 publications

(31 citation statements)

References 115 publications

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“…It is important to identify real markers and develop novel specific therapies to decrease the mortality of PCa (36). Therefore, further study of miRNAs is important (37). The present findings reinforced the tumor-suppressive role of miR-145-5p in PCa, which suggests it as a promising biomarker.…”

Section: Discussionsupporting

confidence: 73%

Long non‑coding RNA AC245100.4 promotes prostate cancer tumorigenesis via the microRNA‑145‑5p/RBBP5 axis

et al. 2020

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Long non-coding RNAs (lncRNAs) are markedly involved in cancer progression. Thus, identification of these lncRNAs can aid in the treatment of cancer. The present study focused on investigating the overall biological function, mechanism of action and clinical importance of lncRNA AC245100.4 in prostate cancer (PCa). The present study identified that AC245100.4 expression was significantly upregulated in PCa tissues and cell lines. Knockdown of AC245100.4 impaired tumor growth in an animal model. Biological function analysis indicated that AC245100.4 overexpression notably promoted cell proliferation and migration, while knockdown of AC245100.4 suppressed cell proliferation and migration. Mechanism studies focused on the competing endogenous RNA (ceRNA) network of AC245100.4. Bioinformatics predictions indicated that both AC245100.4 and retinoblastoma binding protein 5 (RBBP5) had microRNA (miR) response elements for miR-145-5p. This was further verified using a dual luciferase and RNA immunoprecipitation assays. AC245100.4 could positively regulate RBBP5 expression, but negatively regulated miR-145-5p expression. In addition, AC245100.4 knockdown-mediated inhibitory effects on cell proliferation and migration could be reversed by miR-145-5p silencing. Overall, the present study proposed a novel model in which the AC245100.4/miR-145-5p/RBBP5 ceRNA network induced the development of PCa, providing novel insights for PCa treatment.

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Section: Discussionsupporting

confidence: 73%

Long non‑coding RNA AC245100.4 promotes prostate cancer tumorigenesis via the microRNA‑145‑5p/RBBP5 axis

et al. 2020

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“…Increasing evidence has demonstrated that dysregulated expression of microRNAs (miRs/miRNAs) serves critical roles in the tumorigenesis of several types of cancer (27)(28)(29)(30)(31). Highly expressed miR-21 and miR-155 are associated with the metastasis and poor prognosis of colon cancer (30).…”

Section: Introductionmentioning

confidence: 99%

Melatonin inhibits proliferation and viability and promotes apoptosis in colorectal cancer cells via upregulation of the microRNA-34a/449a cluster

Zhou

et al. 2021

Mol Med Rep

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“…Our findings provide evidence that in addition to the regulation of exosome packaging, the expression of EWI-2 on the membrane and NE plays an important role in the miRNA sorting from the nucleus and cytoplasm to exosomes. A series of functional experiments revealed the important role of miRNA in prostate cancer tumorigenesis [57][58][59]. In the present study, a human miRNA microarray was used to analyze the exosomal miRNA expression profiles, and we obtained evidence that in addition to the role of PTRF/Cav-1 in the sorting of extracellular vesicle cargo to exosomes, EWI-2 also plays an important role via its specific location.…”

Section: Ewi-2 Inhibits Caveolin-1 Expression and Further Regulates The Sorting Of Exosomementioning

confidence: 66%

EWI‐2 controls nucleocytoplasmic shuttling of EGFR signaling molecules and miRNA sorting in exosomes to inhibit prostate cancer cell metastasis

Zhang

Wang

et al. 2021

Molecular Oncology

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Early and accurate diagnosis of prostate cancer (PCa) is extremely important, as metastatic PCa remains hard to treat. EWI-2, a member of the Ig protein subfamily, is known to inhibit PCa cell migration. In this study, we found that EWI-2 localized on both the cell membrane and exosomes regulates the distribution of miR-3934-5p between cells and exosomes. Interestingly, we observed that EWI-2 is localized not only on the plasma membrane but also on the nuclear envelope (nuclear membrane), where it regulates the nuclear translocation of signaling molecules and miRNA. Collectively, these functions of EWI-2 found in lipid bilayers appear to regulate PCa cell metastasis through the epidermal growth factor receptor-mitogen-activated protein kinase-extracellular-signal-regulated kinase (EGFR-MAPK-ERK) pathway. Our research provides new insights into the molecular function of EWI-2 on PCa metastasis, and highlights EWI-2 as a potential PCa biomarker.

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Role of miRNAs in prostate cancer: Do we really know everything?

Cited by 36 publications

References 115 publications

Long non‑coding RNA AC245100.4 promotes prostate cancer tumorigenesis via the microRNA‑145‑5p/RBBP5 axis

Long non‑coding RNA AC245100.4 promotes prostate cancer tumorigenesis via the microRNA‑145‑5p/RBBP5 axis

Melatonin inhibits proliferation and viability and promotes apoptosis in colorectal cancer cells via upregulation of the microRNA-34a/449a cluster

EWI‐2 controls nucleocytoplasmic shuttling of EGFR signaling molecules and miRNA sorting in exosomes to inhibit prostate cancer cell metastasis

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