Melatonin inhibits proliferation and viability and promotes apoptosis in colorectal cancer cells via upregulation of the microRNA-34a/449a cluster

Melatonin Induces Autophagy via Reactive Oxygen Species-Mediated Endoplasmic Reticulum Stress Pathway in Colorectal Cancer Cells

“…Moreover, only HT-29 showed a significant decrement of cell viability under 1.0 mM melatonin treatment, whereas SW48 and Caco-2 showed statistically significant decrement of cell viability at 1.5 mM and 2.0 mM, respectively. Our results are in agreement with those of Guangyu et al (2021), who found that melatonin (0.1–2.0 mM) significantly inhibited CRC cell viability in a time- and dose-dependent manner [ 46 ]. Moreover, Farriol et al proved that treatment with 3 mM melatonin could achieve the highest cell death (47%) in the CT-26 murine CRC cell line [ 47 ].…”

Melatonin and verteporfin synergistically suppress the growth and stemness of head and neck squamous cell carcinoma through the regulation of mitochondrial dynamics

“…Recently, Mel has been shown to have anti-tumor effects in different types of cancers. 26,27 In various CSCs, Mel induces apoptosis and autophagy, and regulates mitochondrial function. 28 It suppresses CSC proliferation through the regulation of migration, EMT, and the cell cycle in HNSCC.…”

Silencing Aurora-kinase-A (AURKA) reinforced the sensitivity of diffuse large B-cell lymphoma cells to cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) via suppressing β-Catenin and RAS-extracellular signal-regulated protein kinase (ERK1/2) pathway

“…The apoptosis of OCI-LY7 and Farage cells was determined by flow cytometry using Annexin V-fluorescein Isothiocyanate (FITC)/propidium iodide (PI) cell apoptosis kit (C1062S; Beyotime, Shanghai, China) [ 32 ]. All the operations were performed under the guidance of manufacturer’s instructions.…”