Role of miR-182-5p overexpression in trichloroethylene-induced abnormal cell cycle functions in human HepG2 cells

Jiang, Yan; Zhou, Zijie; Ren, Fei; Zhou, Xuan; Wang, Jin; Tao, Yizhou; Li, Jianxiang; Chen, Tao

doi:10.1080/15287394.2019.1666550

Cited by 7 publications

(2 citation statements)

References 27 publications

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“…Another study has found that plasma and urine miR-21 levels were elevated in patients with AKI after cardiac surgery and were associated with progression of AKI [42]. MiR-182-5p is a recently discovered miRNA, and it is found that miR-182-5p is abnormally expressed in various diseases [43]. There have been several reports about miR-182-5p's functions in the progression of breast cancer and lung cancer.…”

Section: Discussionmentioning

confidence: 99%

Long Noncoding RNA PRNCR1 Reduces Renal Epithelial Cell Apoptosis in Cisplatin-Induced AKI by Regulating miR-182-5p/EZH1

Fan

Wang

et al. 2021

Kidney Blood Press Res

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Background/Aims: This study was designed to examine the role of long noncoding RNA PRNCR1 in cisplatin-induced acute kidney injury (AKI) in vitro and in vivo. Methods: The expression levels of PRNCR1 and miR-182-5p in cisplatin-induced AKI mice were examined. HK-2 cells were treated with cisplatin to induce cell damage. Then, the effects of PRNCR1 and miR-182-5p on cisplatin-stimulated HK-2 cell viability and apoptosis were detected by the CCK-8 and annexin V-FITC/PI method. Target genes of PRNCR1 and miR-182-5p were analyzed by bioinformatics analysis and luciferase. Results: The expression level of PRNCR1 was significantly reduced in cisplatin-induced AKI mice. In addition, overexpression of PRNCR1 attenuated the damage of cisplatin to HK-2. The expression level of miR-182-5p was significantly raised in cisplatin-induced AKI mice. MiR-182-5p was negatively regulated by PRNCR1 and leaded to an upregulation of EZH1 expression. Overexpression of PRNCR1 attenuated cisplatin-induced apoptosis by downregulating the miR-182-5p/EZH1 axis. Conclusion: LncPRNCR1 reduced the apoptosis of renal epithelial cells induced by cisplatin by modulating miR-182-5p/EZH1.

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Section: Discussionmentioning

confidence: 99%

Long Noncoding RNA PRNCR1 Reduces Renal Epithelial Cell Apoptosis in Cisplatin-Induced AKI by Regulating miR-182-5p/EZH1

Fan

Wang

et al. 2021

Kidney Blood Press Res

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“…Knocking down CITED2 expression in lung cancer cells resulted in a shrinkage of tumour size in nude mice and increased host mouse survival rates (21). Other methods, including inducing expression of microRNAs targeting and downregulating Cited2 expression, also results in apoptosis of cancer cells (111). Relapse and metastasis are the major hurdles of cancer therapy, and, whether CITED2 serves a role in cancer relapse or metastasis will be a topic of interest.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Role of CITED2 in stem cells and cancer (Review)

Yang

2020

Oncol Lett

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Cbp/P300 interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2 (CITED2) is a transcription co-factor that interacts with several other transcription factors and co-factors, and serves critical roles in fundamental cell processes, including proliferation, apoptosis, differentiation, migration and autophagy. The interacting transcription factors or co-factors of CITED2 include LIM homeobox 2, transcription factor AP-2, SMAD2/3, peroxisome proliferator-activated receptor γ, oestrogen receptor, MYC, Nucleolin and p300/CBP, which regulate downstream gene expression, and serve important roles in the aforementioned fundamental cell processes. Emerging evidence has demonstrated that CITED2 serves an essential role in embryonic and adult tissue stem cells, including hematopoietic stem cells and tendon-derived stem/progenitor cells. Additionally, CITED2 has been reported to function in different types of cancer. Although the functions of CITED2 in different tissues vary depending on the interaction partner, altered CITED2 expression or altered interactions with transcription factors or co-factors result in alterations of fundamental cell processes, and may affect stem cell maintenance or cancer cell survival. The aim of this review is to summarize the molecular mechanisms of CITED2 function and how it serves a role in stem cells and different types of cancer based on the currently available literature.

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Echinococcus granulosus protoscoleces promotes proliferation and invasion of hepatocellular carcinoma cells

et al. 2020

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Role of miR-182-5p overexpression in trichloroethylene-induced abnormal cell cycle functions in human HepG2 cells

Cited by 7 publications

References 27 publications

Long Noncoding RNA PRNCR1 Reduces Renal Epithelial Cell Apoptosis in Cisplatin-Induced AKI by Regulating miR-182-5p/EZH1

Long Noncoding RNA PRNCR1 Reduces Renal Epithelial Cell Apoptosis in Cisplatin-Induced AKI by Regulating miR-182-5p/EZH1

Role of CITED2 in stem cells and cancer (Review)

Echinococcus granulosus protoscoleces promotes proliferation and invasion of hepatocellular carcinoma cells

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