Role of microbiome in development of systemic inflammatory response syndrome and sepsis (review)

Abstract

Sepsis is a life-threatening organ dysfunction caused by a disturbed response to infection. The development of sepsis is preceded by Systemic Inflammatory Response Syndrome (SIRS), which is the overall inflammatory response of the body to severe lesion. The role of opportunistic pathogens in the development of CER and sepsis may be considered proven, but the value of intestinal microbiome remains underestimated. The survey systematized data on the role of cell wall or membrane components of Gram-positive and Gram-negative bacteria - representatives of intestinal microbiome in pathogenesis of SIRS and sepsis.