Role of Mercaptoethylamine in Repeated Monthly Exposures to Gamma-Radiation in Mice

Dacquisto, Michael P.; Benson, Shirley M.

doi:10.1038/1951116a0

Cited by 4 publications

(2 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, Nelson et al (1969Nelson et al ( , 1971 found protection by cyteamine with fractionation intervals from 1-7 days provided the dose was neither too low nor too high. Efficient protection was obtained for longer intervals of about one month by Wang and Hasegawa (1968) with a protector mixture (dose reduction factor about 2) and by Dacquisto and Benson (1962) with mercaptoethylamine. Most likely the differences between the investigators are due to different doses, fractionation intervals, animal strains and compound utilized.…”

Section: Resultsmentioning

confidence: 99%

“…1484 of the Euratom Biology Division contradictory (Cosgrove et al, 1964;Dacquisto and Benson, 1962;Doull et al, 1963;Holleroft et al, 1957;Maisin, 1968;Maisin et al, 1970Maisin et al, , 1971Maisin and Lambiet-Collier, 1968;Maisin et al, 1977a;Mewissen and Brucer, 1957;Nelson et al, 1963Nelson et al, , 1967Nelson et al, , 1971Upton et al, 1959;Wand and Hasegawa, 1968), and it is uncertain whether the late damage in the animals protected against the acute effects is repaired as efficiently as it is in nonprotected animals which received a lower dose corresponding to a same survival rate. In order to obtain more information on these questions -repair with respect to late effects and the effects of radioproteetors on this repair -normal and protected mice were irradiated at regular intervals until death.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Repair and biochemical protection in life shortening of mice exposed to fractionated X-irradiation

Maisin

Gerber

Lambiet-Collier

et al. 1978

Radiat Environ Biophys

View full text Add to dashboard Cite

Male mice of the BALB/c+ strain were exposed to X-rays at fractionation intervals of 7, 15, 30, and 60 days. One group received a mixture of radioprotectors, another AET (only 30 days fractionation), a third one served as control. The doses ranged, dependent on the treatment, from 300--1500 R. When survival was corrected for acute death, the control and AET treated animals died after an accumulated dose of about 2000 R whereas those treated with a mixture of radioprotectors died after about 4000 tr. Bone marrow failure and lung damage is the main cause of death within the initial 200 days after start of the exposure. At later times, fibrotic changes and in particular glomerulosclerosis are observed.

show abstract

Section: Resultsmentioning

confidence: 99%