Role of mean platelet volume in triagging acute coronary syndromes

Yilmaz, Mehmet Birhan; Cihan, Gökhan; Güray, Yeşım; Güray, Ümit; Kisacik, Halil; Şaşmaz, Hatice; Korkmaz, Şule

doi:10.1007/s11239-007-0078-9

Cited by 91 publications

(77 citation statements)

References 26 publications

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“…[14][15][16] . The risk of restenosis following higher with patients has higher MPV [17][18][19][20][21][22][23] .…”

Section: Resultsmentioning

confidence: 99%

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A Comparative Analysis of Mean Platelet Volume and Other Platelet Indices in Patient of Acute Myocardial Infarction with Healthy ControlProspective Study

Pipliwal¹

2017

jmscr

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“…[14][15][16] . The risk of restenosis following higher with patients has higher MPV [17][18][19][20][21][22][23] .…”

Section: Resultsmentioning

confidence: 99%

“…MPV and other platelet indices correlates not only an increased risk of non STEMI, but also ischemic complications 4 . Also some studies have reported an association between high MPV and poor prognosis in IHD, but few studies to determine relation between IHD and other platelet indices such PDW, P-LCR and PCT.…”

Section: Introductionmentioning

confidence: 99%

A Comparative Analysis of Mean Platelet Volume and Other Platelet Indices in Patient of Acute Myocardial Infarction with Healthy ControlProspective Study

Pipliwal¹

2017

jmscr

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“…In our study, MPV was evaluated in young patients with NSTE-ACS. Thrombogenic activity is known to be higher in NSTE-ACS, and it has been shown to play an essential role in the etiopathogenesis of NSTE-ACS (1,23). Likewise, MPV were found to be higher in myocardial infarction patients with normal coronary arteries (24).…”

Section: Discussionmentioning

confidence: 96%

Predictive value of mean platelet volume in young patients with non-ST-segment elevation acute coronary syndromes: a retrospective observational study

Özlü¹,

Öztürk²,

Ayhan³

et al. 2012

Anadolu Kardiyol Derg

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Predictive value of mean platelet volume in young patients with non-ST-segment elevation acute coronary syndromes: a retrospective observational study ST-yükselmesiz ABSTRACTObjective: Platelets play an important role in both initiation and propagation of acute coronary syndromes. We sought to evaluate the predictive value of mean platelet volume (MPV) in young patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACS).Methods: This is a retrospective observational study; evaluating the MPV values of 79 NSTE-ACS patients aged under 45 years and 45 control subjects having normal coronary anatomy. NSTE-ACS group was composed of 41 non-ST elevation myocardial infarction (NSTEMI) and 38 unstable angina pectoris (USAP) patients. MPV was measured using an automated hematologic analyzer called Coulter counter. The predictive value of MPV was evaluated using logistic regression analysis and comparison of MPV between NSTE-ACS and control groups was performed by Mann-Whitney U test. Results: The MPV was found to be significantly higher in the NSTE-ACS compared with control group (8.49±1.22 versus 7.78±0.65 fL, p=0.001).In logistic regression analysis, MPV was found to be an independent predictor of NSTE-ACS (OR=3.1, 95% CI 1.

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“…Several studies have reported elevated MPV which has been proposed as a cardiovascular risk factor and has been recognized as an independent risk factor for myocardial infarction and adverse cardiovascular events such as recurrent ischemia or death 27,28 . Several reports have also reported that MPV was associated with restenosis after primary coronary intervention 16,21 .…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of postprocedural mean platelet volume on one-year major cardiac outcomes in ST-elevation myocardial infarction after percutaneous coronary intervention

Lang¹,

Luan²,

Li³

et al. 2015

ICFJ

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Platelet-induced inflammation may play a critical role in atherothrombosis 1 , and is thought to be the major cause of unstable coronary syndromes 2 . STEMI is a major and clinically important event. Platelet activity is a major culprit in contributing to thrombus formation or apposition after coronary plaque rupture 3 . MPV, a simple and reliable parameter used to measure the platelet, is a potential marker of platelet reactivity. Larger platelets are metabolically and enzymatically more active than smaller platelets and have an increased production of vasoactive and prothrombotic factors [4][5][6][7] , including increased platelet aggregation, increased thromboxane synthesis β-thromboglobulin release, and increased expression of adhesion molecules 8 . Few studies have evaluated the prognostic value of MPV in patients suffering from myocardial infarction (MI) [9][10][11][12] and recent studies have focused on STsegment elevation MI 11,12 .Balloon injury and stent implantation can also injury vascular endothelium and activate platelets. Recently, it has been confirmed that the circulating WBC count is altered after PCI 13,14 . Increased post-procedural WBC is an independent predictor of poor clinical outcomes in STEMI patients who underwent PCI 15. However, whether MPV is altered after PCI and whether post-procedural MPV is associated with MCO following PCI remains unknown. Therefore, this study was designed to investigate whether mean platelet volume is associated with 1-year MCO in patients with STEMI after PCI. MethodsA total of 301 consecutive patients with acute STEMI were recruited to the study from January 2011 to June 2012. All patients were treated with successful primary PCI. They were divided into 2 groups (G) according to their mean platelet volume (G1≤ 9.9 fl, n=101; G2 > 9.9 fl, n=200) measured within 12 hours after PCI. STEMI was defined as ST-elevation of ≥0.1mV in >limb lead or ≥0.2mV in contiguous chest leads or left bundle branch block (LBBB) at presentation. Patients with concomitant infectious diseases, neoplastic disease or hematological disorders were excluded from this study. The time interval from the onset of chest pain to vascular reperfusion was less than 12 hours. All patients had taken Aspirin, Alopidogrel, Atorvastatin, ACEIs or ARBs, Beta blockers, and Calcium antagonists (according to their required blood pressure, and heart rate adjustments). All patients were continuously followed using telephone contact or clinical interview for one year. MCO was defined as death from any cause, non-fatal MI, re-angina, re-hospital and stroke. This study was approved by the Ethics Committee of Ningxia People's Hospital. Statistical AnalysisAll data were analyzed using SPSS18.0. Descriptive statistics were presented as the mean±standard deviation (SD) for continuous variables. Comparison between groups was performed by means of independent samples t test. Categorical variables were compared by the chi-square test. The AbstractThe aim of this study was to investigate the association of mean plat...

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Role of mean platelet volume in triagging acute coronary syndromes

Abstract: In patients presenting with NSTE ACS, higher MPV, though there are overlaps among subgroups, indicates not only more risk of having NSTEMI but also ischemic complications.

Cited by 91 publications

References 26 publications

A Comparative Analysis of Mean Platelet Volume and Other Platelet Indices in Patient of Acute Myocardial Infarction with Healthy ControlProspective Study

A Comparative Analysis of Mean Platelet Volume and Other Platelet Indices in Patient of Acute Myocardial Infarction with Healthy ControlProspective Study

Predictive value of mean platelet volume in young patients with non-ST-segment elevation acute coronary syndromes: a retrospective observational study

Prognostic value of postprocedural mean platelet volume on one-year major cardiac outcomes in ST-elevation myocardial infarction after percutaneous coronary intervention

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