A Comparative Analysis of Mean Platelet Volume and Other Platelet Indices in Patient of Acute Myocardial Infarction with Healthy ControlProspective Study

Pipliwal, Dr P.S

doi:10.18535/jmscr/v5i2.31

Cited by 3 publications

(5 citation statements)

References 9 publications

(11 reference statements)

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“…There was no significant difference in platelet count; however, there was a decreased platelet count in STEMI and NSTEMI compared to UA patients (Table 2). This result was consistent with other 9,24,26 previous studies.…”

Section: Resultssupporting

confidence: 94%

“…This study also failed to find any significant difference in PCT among three ACS groups. The previous studies conducted by Al-Obeidi et al, Pipliwal et al, and Costa et al also found similar 24,29,30 results with this recent study.…”

Section: Resultssupporting

confidence: 91%

“…This study result was consistent with previous study results. Platelet distribution width values of MI patients were higher 14,15,24 than UA patients and healthy control. The increase of PDW correlated with an increase of 25 platelet production and activity in thrombosis.…”

Section: Resultsmentioning

confidence: 75%

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Immature Platelet Fraction as A Potential Marker To Differentiate Types of Acute Coronary Syndrome

Indriastuti

Hernaningsih

Indrasari

et al. 2020

Indonesian J. Clin. Pathol. Med. Lab.

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Acute Coronary Syndrome (ACS) includes ST-Elevation Myocardial Infarction (STEMI), non-ST Elevation MyocardialInfarction (NSTEMI), and Unstable Angina (UA). Platelet plays an essential role in ACS pathogenesis. Immature PlateletFraction (IPF) and platelet indices can predict platelet activations. Platelet indices consist of platelet count, Mean PlateletVolume (MPV), Platelet Distribution Width (PDW), plateletcrit (Pct). This study aimed to analyze the differences of IPF andplatelet indices among ACS patients. This study was an observational analytical cross-sectional study conducted inDr. Soetomo Hospital during May-September 2019. The subjects consisted of 30-STEMI, 25-NSTEMI, and 24-UA patients.The EDTA-samples were measured for platelet indices and IPF using Sysmex XN-1000. The differences between IPF andplatelet indices among STEMI, NSTEMI, and UA patients were analyzed using Kruskal-Wallis and Mann-Whitney test. The IPFvalues were significantly higher in STEMI patients than NSTEMI and UA patients. The IPF values of NSTEMI patients werehigher than UA patients. The MPV, PDW, and P-LCR were significantly higher in STEMI and NSTEMI compared to UA. TheMPV, PDW, and P-LCR values of NSTEMI patients were significantly higher than UA patients. The significant differencesbetween STEMI and NSTEMI toward UA might be caused by the more severe thrombotic conditions in myocardial infarctionpatients than UA. The IPF values were significantly different among each type of ACS patients gave an opportunity using thisparameter to differentiate the ACS types. The MPV, PDW, and P-LCR were significantly higher in myocardial infarctionpatients than UA patients, which also allowed them to use those parameters to differentiate both conditions.

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Section: Resultssupporting

confidence: 94%

Section: Resultssupporting

confidence: 91%

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Immature Platelet Fraction as A Potential Marker To Differentiate Types of Acute Coronary Syndrome

Indriastuti

Hernaningsih

Indrasari

et al. 2020

Indonesian J. Clin. Pathol. Med. Lab.

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“…Progressive platelet activation even will lead to a change in platelet morphology including spherical transformation, and pseudopodia formation, which will cause platelet size to vary, generating PDW value in myocardial infarction patients higher than in controls. [10][11][12] Similarly, the results of the Kruskal-Wallis test showed that there was a significant difference in PDW values between STEMI group, NSTEMI, group, UAP group, and the control (p=0.000) as shown in Table 2. The results of the Mann-Whitney test also showed that there were significant differences in PDW of each of STEMI group, NSTEMI group, and UAP group from the control (p=0.000) as demonstrated in Table 3.…”

Section: Methodsmentioning

confidence: 91%

Platelet Distribution Width Value as a Diagnostic and Prognostic Marker in Acute Coronary Syndrome

Latif

Kurniawan

Rauf

2018

Indonesian J. Clin. Pathol. Med. Lab.

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An acute coronary syndrome is a form of clinical manifestation of coronary heart disease with atherosclerosis, and thrombosis processes. Platelets play an essential role in thrombosis. High PDW shows a variation of the morphology, and size of a platelet. This was a retrospective cross-sectional study comparing PDW, length of stay, and patient outcome in STEMI, NSTEMI, UAP, and control patients at the Dr.Wahidin Sudirohusodo Hospital Makassar during the period of January 2014 – December 2015. Data were analyzed using statistical software. One hundred, and seventy-two ACS patients were included; 65 patients had UAP, 48 patients had STEMI and 59 patients had NSTEMI. Sixty normal patients were included as a control. Kruskal-Wallis test showed a statistical difference in PDW between patients with STEMI, NSTEMI, UAP, and control (p=0.000). Post hoc test showed a significant difference between ACS, and control, STEMI, and control (p=0.000), NSTEMI and control (p=0.000), UAP, and control (p=0.000), but there no significant difference between STEMI, and NSTEMI (p=0.320), STEMI, and UAP (p=0.980), NSTEMI and UAP (p=0.435). There was no significant difference in PDW between patients who survived, and died (p=0.298), and also patients with a length of stay of ≤ 7 days, and > 7 days (p=0.293). Platelet distribution width was higher in ACS patients compared with control patients, but could not be used to predict the outcome, and length of stay of patients with ACS. It is advisable to do further research with a large sample size to avoid bias.

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“…Page 3431 Similarly as described in table 7, Cameron et al, Martin et al, Martin et al, Pizzulli et al, Khanderkar et al, MP Ranjith et al, Prem shanker pipliwal et al, G. Ranjani et al, and Vitthal Khode compared MPV between IHD patients and control groups and found to have MPV 9.07, 7.3, 10.09±1.43, 9.4±1.23, 10.43±1.03, 10.97±0.58, 11.97±1.458, 9.8±0.86(AMI) -9.5±0.84(UA) and 9.65±0.96 fl respectively, which are significantly higher in as compared to control groups [13][14][15][16][17]. …”

mentioning

confidence: 99%

The role of platelet indices in ischemic heart disease: a hospital based case control type of study

Gandhi

Gamit

2019

Int J Res Med Sci

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Background: In developing countries, Ischemic heart diseases (IHD) is one of the leading causes of morbidity and mortality. The underlying pathology of CAD is atherosclerosis. When this atherosclerotic plaque ruptures, platelets play a crucial role in the prothrombotic events and forms a thrombus on this plaque and as a result coronary artery gets occluded causing ischemia and infarction. Platelet contains many chemokines, cytokines and growth factors. Release of these factors along with interaction with endothelial cells and leukocytes promotes inflammation and progression of atherosclerosis. We aimed to investigate the association between platelet volume indices in patients with diagnosis of Ischemic heart disease in comparison with control group.Methods: By using automated cell counter platelet count and platelet volume indices - were compared with Normal healthy or non-cardiac chest pain patients with the use of unpaired t test.Results: In the present study, we demonstrated that platelet count is significantly low and MPV and PDW are significantly high in Ischemic heart disease as compared to patients with noncardiac chest pain or healthy subjects. The correlation of MPV with PC revealed an inverse correlation between the patients of IHD and healthy or non-cardiac chest pain patients which is statistically significant.Conclusions: The platelet volume indices are an important, simple, effortless and a cost-effective tool useful in predicting the development of an acute coronary event sometimes in the near future and therapeutic modification for improved patient’s cardiovascular care.

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A Comparative Analysis of Mean Platelet Volume and Other Platelet Indices in Patient of Acute Myocardial Infarction with Healthy ControlProspective Study

Cited by 3 publications

References 9 publications

Immature Platelet Fraction as A Potential Marker To Differentiate Types of Acute Coronary Syndrome

Immature Platelet Fraction as A Potential Marker To Differentiate Types of Acute Coronary Syndrome

Platelet Distribution Width Value as a Diagnostic and Prognostic Marker in Acute Coronary Syndrome

The role of platelet indices in ischemic heart disease: a hospital based case control type of study

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