Role of matrix metalloproteinases (MMPS) in periodontitis and its management

Keller, Charles; Nalini, HEsther; Reddy, N Raghavendra; Palani, Arun; Ramamurthy, Renuka Devi; Sankaralingam, Thirumalai

doi:10.4103/2229-3019.148262

Cited by 10 publications

(2 citation statements)

References 13 publications

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“…The host's immune-inflammatory responses elicited to overcome these bacterial challenges are mediated by numerous cytokines [1]. The role of inflammatory mediators such as interleukin (IL)-1, tumor necrosis factor (TNF)-α, prostaglandins and matrix metallo-proteinases (MMPs) has been extensively studied and understood in terms of their significance in periodontal tissue breakdown [2][3][4]. These inflammatory mediators determine the clinical manifestation, extent and severity of diseases, and thus serve as indicators/markers for the diagnosis and prognosis of periodontal diseases.…”

Section: Introductionmentioning

confidence: 99%

Comparative Evaluation of Gingival Crevicular Fluid Interleukin-17, 18 and 21 in Different Stages of Periodontal Health and Disease

et al. 2022

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Background and Objectives: The elicitation of a host’s immune–inflammatory responses to overcome oral bacterial biofilm challenges is mediated by numerous cytokines. We explored the role of three such cytokines, viz. interleukin (IL)-17, 18 and 21, by measuring their levels in the gingival crevicular fluid (GCF) of Indian individuals with healthy gingiva, chronic gingivitis, or chronic periodontitis. Materials and Method: Ninety systemically healthy individuals were enrolled in the study on the basis of predefined criteria and were categorized into three groups of 30 participants each. Groups A, B and C were composed of a control group with healthy gingiva, subjects with chronic gingivitis and subjects with chronic periodontitis, respectively. The periodontal disease status was assessed on the basis of a subject’s gingival index, probing pocket depth, clinical attachment loss and radiographic evidence of bone loss. After the complete history-taking and identification of gingival sulcus/pocket depth areas for GCF collection, a sample was collected from each subject in all groups for an estimation of the cytokine levels using ELISA. Statistical analysis was performed using SPSS v 21.0. Intergroup comparisons were conducted using a post hoc Tukey’s test. A value of p < 0.05 was considered to be statistically significant. Results: The mean IL-17, 18 and 21 concentrations in pg/mL was the greatest for Group C (99.67 ± 18.85, 144.61 ± 20.83 and 69.67 ± 12.46, respectively), followed by Group B (19.27 ± 2.78, 22.27 ± 2.43 and 22.74 ± 1.43, respectively) and finally by Group A (healthy control; 11.56 ± 0.99, 17.94 ± 1.24 and 12.83 ± 1.21 respectively). A statistically significant difference in the mean concentrations of two interleukins (IL-17 and IL-18) was observed between Groups A and C and also between Groups B and C. A statistically significant difference in the mean concentrations of IL-21 was observed between Groups B and C. Conclusions: Within the limitations of the present study, the findings revealed that the GCF levels of IL-17, IL-18 and IL-21 rose and correlated well with the severity of the disease. Thus, these cytokines present in GCF have the potential to be considered as biomarkers for periodontal tissue destruction. IL-21 in particular appears to be a promising biomarker for differentiating between gingivitis and periodontitis.

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Section: Introductionmentioning

confidence: 99%

Comparative Evaluation of Gingival Crevicular Fluid Interleukin-17, 18 and 21 in Different Stages of Periodontal Health and Disease

et al. 2022

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“…One of the biological roles of MMP-8 is to facilitate the migration of neutrophil granulocytes from circulation into the tissues, including periodontium, by cleavage of collagen and other ECM components [ 13 ]. The uncontrolled increased expression, release, and activation of MMPs and other proteinases, including MMP-8, is thought to induce an inflammatory response, which leads to the destruction of periodontal tissues and other inflammatory diseases [ 14 ].…”

Section: Mmp-8mentioning

confidence: 99%

Matrix Metalloproteinases in Oral Health—Special Attention on MMP-8

et al. 2023

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Matrix metalloproteinases (MMPs) are a large family of Ca2+ and Zn2+ dependent proteolytic enzymes, able to cleave the various components of the extracellular matrix (ECM), as well as a range of other regulatory molecules. Several reports have proven the important role of both MMPs and their endogenous inhibitors, TIPMs, in oral health, the initial development of the tooth, and during enamel maturation. In this mini-review, we aim to summarize the literature information about the functions of MMPs, paying more attention to MMP-8 (collagenase-2 or neutrophil collagenase) in the development and progression of periodontitis, peri-implantitis, and carious lesions. We also emphasize the role of particular gene variants in MMP8 as predisposing factors for some oral diseases.

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