Role of mast cells in ion transport abnormalities associated with intestinal anaphylaxis. Correction of the diminished secretory response in genetically mast cell-deficient W/Wv mice by bone marrow transplantation.

Perdue, Mary H.; Masson, Stephen; Wershil, Barry K.; Galli, Stephen J.

doi:10.1172/jci115047

Cited by 151 publications

(64 citation statements)

References 40 publications

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“…Furthermore, these studies reveal a link between mast cell/chymase-mediated epithelial migration and the regulation of homeostatic intestinal barrier function. Previous studies have examined the role of mast cells in intestinal barrier function during oral antigen-or helminthinduced intestinal inflammation (17)(18)(19)(20). Repeated oral administration of ovalbumin to ovalbumin-immunized mice induced an IgE/Fc RI/mast cell-dependent increase in intestinal epithelial permeability and secretory diarrhea (18,19).…”

Section: Mast Cells/mcpt4mentioning

confidence: 99%

“…Previous studies have examined the role of mast cells in intestinal barrier function during oral antigen-or helminthinduced intestinal inflammation (17)(18)(19)(20). Repeated oral administration of ovalbumin to ovalbumin-immunized mice induced an IgE/Fc RI/mast cell-dependent increase in intestinal epithelial permeability and secretory diarrhea (18,19). Furthermore, T. spiralis infection induced intestinal mastocytosis and intestinal permeability through a protease-dependent process (17).…”

Section: Mast Cells/mcpt4mentioning

confidence: 99%

See 1 more Smart Citation

Mast cells regulate homeostatic intestinal epithelial migration and barrier function by a chymase/Mcpt4-dependent mechanism

Groschwitz¹,

Ahrens²,

Osterfeld³

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

152

140

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Section: Mast Cells/mcpt4mentioning

confidence: 99%

Section: Mast Cells/mcpt4mentioning

confidence: 99%

Mast cells regulate homeostatic intestinal epithelial migration and barrier function by a chymase/Mcpt4-dependent mechanism

Groschwitz¹,

Ahrens²,

Osterfeld³

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

152

140

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“…Evidence for mast cell-nerve interaction occurring in the intestine was provided by Perdue and co-workers (19) in 1991, in a study of mast cell deficient W/W v mice and congenic controls. Intestine from these mice was removed and mounted in Ussing chambers for measurement of electrophysiological parameters.…”

Section: Nerve-immune Cell Interactionsmentioning

confidence: 97%

Effect of Psychoneural Factors on Intestinal Epithelial Function

Berin¹,

Perdue²

1997

Canadian Journal of Gastroenterology

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W olf and Wolff (1) described vascular and motor changes associated with various moods in a patient with a gastric fistula. Stress has been associated with abnormal gastrointestinal function, including diarrhea and abdominal pain (2), and stress-associated gastric ulceration has frequently been documented. Stress can also exacerbate ongoing pathophysiology, and often precedes relapses in patients with inflammatory bowel disease or irritable bowel syndrome (3). The relatively new field of psychoneuroimmunology is involved with the elucidation of mechanisms that explain the link between the central nervous system (CNS) and immune-mediated pathophysiology. This review discusses recent progress examining the interaction among the nervous system, the immune system and the epithelium of the intestine, and examines the evidence for CNS control of this interaction. INTESTINAL EPITHELIUMThe intestine is lined with a single layer of epithelial cells that form a barrier between the lumen contents and the interstitium. The epithelial layer has two main roles: transport and barrier functions. Tight junctions between enterocytes Stress has been associated with abnormal gastrointestinal function, including diarrhea and abdominal pain, and stress-associated gastric ulceration has frequently been documented. Stress can also exacerbate ongoing pathophysiology and often precedes relapses in patients with inflammatory bowel disease or irritable bowel syndrome. The relatively new field of psychoneuroimmunology is involved with the elucidation of mechanisms that explain the link between the central nervous system and immune-mediated pathophysiology. Recent progress examining the interaction among the nervous system, the immune system and the epithelium of the intestine is discussed, and the evidence for central nervous sysytem control of this interaction is examined. Key Words: Abnormal gastrointestinal function, Intestinal epithelium, Psychoneuroimmunology, StressEffet des facteurs psychoneuraux sur la fonction épithéliale intestinale RÉSUMÉ : Le stress a été associé à la dysfonction gastrointestinale, y compris à la diarrhée et à la douleur abdominale et des ulcères gastriques associés au stress ont souvent été documentés. Le stress peut également exacerber la physiopathologie existante et précède souvent la rechute chez des patients atteints de maladie inflammatoire de l'intestin ou du syndrome du côlon irritable. Nouveau domaine de recherche, la psychoneuro-immunologie se penche sur l'élucidation des mécanismes pouvant expliquer le lien entre le système nerveux central et la physiopathologie à médiation immunitaire. De récents progrès réalisés grâce à l'examen d'une interaction entre le système nerveux, le système immunitaire et l'épithélium intestinal sont abordés ici, de même que certaines preuves du contrôle de cette interaction par le système nerveux central.

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“…In the summer of 1993 I met Lars Thuneberg and Hanne Mikkelsen at the 14th International Symposium on Gastrointestinal Motility in Muskoka, Ontario and we discussed the project in Lars' hotel room and planned the immunohistochemistry and electron microscopy . It so happened that Mary Perdue occupied the offi ce next to mine and she was working on WWv mice that lacked the c-Kit receptor (Perdue et al 1991 ). She was interested in the role of mast cells in infl ammation and I realized that the WWv mouse would be perfect for this study.…”

Section: The Incorporation Of Interstitial Cells Of Cajal In the Myogmentioning

confidence: 99%

Ageing and Gastrointestinal Sensory Function

Keating

Grundy

2016

Advances in Experimental Medicine and Biology

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Myogenic control mechanisms play a role in all motor activities of the gut. Myogenic control systems are defi ned here as control systems that are intrinsic to the smooth muscle cells and/or interstitial cells of Cajal (ICC) and that can operate without an essential contribution of the intrinsic (ENS) and extrinsic nervous systems . In vivo however, the ENS and the myogenic control systems always work in cooperation. Although myogenic control plays a role in every gut organ, this review focuses on the peristaltic and segmentation activity of the small intestine. It provides some historical perspectives and some discussion on the development of our understanding of the cooperative nature of the myogenic and neurogenic control mechanisms . It highlights how some infl uential papers inadvertently provided hindrance to full understanding, it discusses how the guinea pig model has hampered acceptance of myogenic control systems and it provides some background into the genesis of our understanding of control mechanisms involving ICC. The Dominance of the "Law of the Intestine"Nothing has hampered the acceptance of myogenic control mechanisms more than the formulation of the " law of the intestine " by Bayliss and Starling. The likely reason is the elegant descriptions of the evidence for it and the attractive nature of such a simple and effective, easily understood mechanism. This despite the fact that Bayliss and Starling prominently described myogenic control systems as well. In Bayliss and Starling's seminal paper from 1889 where the "law of the intestine"

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Role of mast cells in ion transport abnormalities associated with intestinal anaphylaxis. Correction of the diminished secretory response in genetically mast cell-deficient W/Wv mice by bone marrow transplantation.

Cited by 151 publications

References 40 publications

Mast cells regulate homeostatic intestinal epithelial migration and barrier function by a chymase/Mcpt4-dependent mechanism

Mast cells regulate homeostatic intestinal epithelial migration and barrier function by a chymase/Mcpt4-dependent mechanism

Effect of Psychoneural Factors on Intestinal Epithelial Function

Ageing and Gastrointestinal Sensory Function

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