Role of magnetic resonance methods in the evaluation of prostate cancer: an Indian perspective

Jagannathan, Naranamangalam R.; Kumar, Virendra; Kumar, Rajeev; Thulkar, Sanjay

doi:10.1007/s10334-008-0122-6

Cited by 15 publications

(11 citation statements)

References 134 publications

(231 reference statements)

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“…The Cit and Cho levels observed by MRS are usually expressed by using ratios of the integral of the resonance peak of metabolites; for example, Cit/Cho, (Cit/[Cho + Cr]) or ([Cho + Cr]/Cit). 29,30 MRSI, an advanced variation of MRS, has made it possible to acquire high-resolution proton spectra from the entire prostate in a clinically reasonable amount of time. 31 Using 3D-MRSI, the (Cho + Cr)/Cit ratio was found to be a specific marker for prostate cancer, with 98% of the cancer ratios falling above three standard deviations of the mean healthy PZ value.…”

Section: H Mrs Of the Prostatementioning

confidence: 99%

Prebiopsy magnetic resonance spectroscopy and imaging in the diagnosis of prostate cancer

Kumar¹,

Jagannathan²,

Thulkar³

et al. 2012

Int J of Urology

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Introduction: Existing screening investigations for the diagnosis of early prostate cancer lack specificity, resulting in a high negative biopsy rate. There is increasing interest in the use of various magnetic resonance methods for improving the yield of transrectal ultrasound‐guided biopsies of the prostate in men suspected to have prostate cancer. We review the existing status of such investigations. Methods: A literature search was carried out using the Pubmed database to identify articles related to magnetic resonance methods for diagnosing prostate cancer. References from these articles were also extracted and reviewed. Results: Recent studies have focused on prebiopsy magnetic resonance investigations using conventional magnetic resonance imaging, dynamic contrast enhanced magnetic resonance imaging, diffusion weighted magnetic resonance imaging, magnetization transfer imaging and magnetic resonance spectroscopy of the prostate. This marks a shift from the earlier strategy of carrying out postbiopsy magnetic resonance investigations. Prebiopsy magnetic resonance investigations has been useful in identifying patients who are more likely to have a biopsy positive for malignancy. Conclusions: Prebiopsy magnetic resonance investigations has a potential role in increasing specificity of screening for early prostate cancer. It has a role in the targeting of biopsy sites, avoiding unnecessary biopsies and predicting the outcome of biopsies.

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Section: H Mrs Of the Prostatementioning

confidence: 99%

Prebiopsy magnetic resonance spectroscopy and imaging in the diagnosis of prostate cancer

Kumar¹,

Jagannathan²,

Thulkar³

et al. 2012

Int J of Urology

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“…As discussed earlier, most applications of MR in PCa are used in clinical MRI and in vivo 1 H MRS . In terms of imaging, MRI is arguably the best technique currently available as a result of the high water content present in human tissues.…”

Section: Progress In Nmr Methods For Prostate Cancermentioning

confidence: 99%

High‐resolution NMR spectroscopy of human body fluids and tissues in relation to prostate cancer

2013

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High-resolution NMR spectroscopic studies of prostate tissue extracts, prostatic fluid, seminal fluid, serum and urine can be used for the detection of prostate cancer, based on the differences in their metabolic profiles. Useful diagnostic information is obtained by the detection or quantification of as many metabolites as possible and comparison with normal samples. Only a few studies have shown the potential of high-resolution in vitro NMR of prostate tissues. A survey of the literature has revealed that studies on body fluids, such as urine and serum, in relation to prostate cancer are rare. In addition, the potential of NMR of nuclei other than (1)H, such as (13)C and (31)P, has not been exploited fully. The metabolomic analysis of metabolites, detected by high-resolution NMR, may help to identify metabolites which could serve as useful biomarkers for prostate cancer detection. Such NMR-derived biomarkers would not only help in prostate cancer detection and in understanding the in vivo MRS metabolic profile, but also to investigate the biochemical and metabolic changes associated with cancer. Here, we review the published research work on body fluids in relation to prostate and prostate tissue extracts, and highlight the potential of such studies for future work.

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“…In addition, Jagannathan et al . reported an interesting finding regarding ADC in PZ cancer, namely that, in Asian men, as compared with American, African‐American and European men, ADC values tended to be lower. Thus, ethnic differences in ADC values should also be investigated.…”

Section: Image Interpretation Of Dw‐mrimentioning

confidence: 97%

Diffusion‐weighted MRI and its role in prostate cancer

Tamada

Sone

et al. 2013

NMR in Biomedicine

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In the last 5 years, the multiparametric approach has been investigated as the method for the MRI of prostate cancer. In multiparametric MRI of the prostate, at least two functional MRI techniques, such as diffusion-weighted MRI (DW-MRI) and dynamic contrast-enhanced MRI, are combined with conventional MRI, such as T2 -weighted imaging. DW-MRI has the ability to qualitatively and quantitatively represent the diffusion of water molecules by the apparent diffusion coefficient, which indirectly reflects tissue cellularity. DW-MRI is characterized by a short acquisition time without the administration of contrast medium. Thus, DW-MRI has the potential to become established as a noninvasive diagnostic method for tumor detection and localization, tumor aggressiveness, local staging and local recurrence after various therapies. Accordingly, radiologists should recognize the principles of DW-MRI, the methods of image acquisition and the pitfalls of image interpretation.

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Role of magnetic resonance methods in the evaluation of prostate cancer: an Indian perspective

Cited by 15 publications

References 134 publications

Prebiopsy magnetic resonance spectroscopy and imaging in the diagnosis of prostate cancer

Prebiopsy magnetic resonance spectroscopy and imaging in the diagnosis of prostate cancer

High‐resolution NMR spectroscopy of human body fluids and tissues in relation to prostate cancer

Diffusion‐weighted MRI and its role in prostate cancer

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