Role of LncRNA-AF085935, IL-10 and IL-17 in Rheumatoid Arthritis Patients With Chronic Hepatitis C

Sabry, Dina; Elamir, Azza; Mahmoud, Rania H.; Abdelaziz, Ahmed; Fathy, Wael

doi:10.14740/jocmr2896w

Cited by 11 publications

(10 citation statements)

References 59 publications

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“…47 Pro-inflammatory cytokines, including TNF-α and IL-6, exert great effects on the development of chronic inflammation and joint destruction. 48,49 In recent years, emerging evidence has supported the crucial role of lncRNA-NR024118 during the inflammatory response of RA. 12 Consistent with our results, Yan et al 50 have demonstrated that lncRNA XIST knockdown could suppress the inflammation in nervous tissues by reducing the levels of TNF-α and IL-6.…”

Section: Discussionmentioning

confidence: 99%

Retracted: Long non‐coding RNA XIST binding to let‐7c‐5p contributes to rheumatoid arthritis through its effects on proliferation and differentiation of osteoblasts via regulation of STAT3

Wang

Xiu

Jiang

et al. 2020

Clinical Laboratory Analysis

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Rheumatoid arthritis (RA) is a chronic and inflammatory disorder, which can result in joint destruction, deformity, and even disability. 1 However, the etiology and pathogenesis of RA remain unclear, although it has been hypothesized that RA may result from the combined effects of genetic and environmental factors. 2,3 RA is associated with multiple characteristics, including cartilage degradation, bone erosion, and joint instability. 4 Nowadays, RA is reported to affect approximately 1% of the world population, while the life quality of RA patients and their life expectancy have both been reduced by this disease. 5,6 The impact of inflammation in osteoblasts has been proved, which displays crucial roles within the arthritic bone microenvironment, and, thus, in RA pathogenesis. 7 Although there are some therapies available for the

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Section: Discussionmentioning

confidence: 99%

Retracted: Long non‐coding RNA XIST binding to let‐7c‐5p contributes to rheumatoid arthritis through its effects on proliferation and differentiation of osteoblasts via regulation of STAT3

Wang

Xiu

Jiang

et al. 2020

Clinical Laboratory Analysis

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“…IL-10 is a cytokine with immunosuppression and regulation effects [20], but this has rarely been investigated in RA patients [21,22]. Research using animal RA models showed that IL-10 suppresses the immune response and inflammatory reaction in vivo , and helps to relieve RA symptoms [23,24].…”

Section: Introductionmentioning

confidence: 99%

Treatment of Type II Collagen-Induced Rat Rheumatoid Arthritis Model by Interleukin 10 (IL10)-Mesenchymal Stem Cells (BMSCs)

Tian

Yan

et al. 2019

Med Sci Monit

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Background Rheumatoid arthritis model (CIA) rats were treated by tail vein injection of IL-10-modified bone marrow mesenchymal stem cells (BMSCs) to investigate its feasibility and intrinsic molecular mechanism. Material/Methods The CIA rat model was established by induction type II collagen, and IL-10-modified BMSCs was established by transfecting BMSCs with adenovirus. IL-10-modified BMSCs were used to treat the CIA rats. The therapeutic effect was evaluated by measuring the changes in body weight, ankle swelling, and forced swimming time, as well as observation of synovial hyperplasia and cartilage tissue repair by HE staining. Western blot analysis and ELISA were used to detect gene expression. Results After 4 weeks and 8 weeks of treatment with IL10-BMSCs, the body weight, swelling value, resting time, and forced swimming struggle time of CIA rats were significantly higher than those of BMSCs-treated and -untreated CIA rats (P<0.05). Compared to BMSCs-treated CIA model rats, after treatment with IL10-BMSCs, the repair rate of osteoarticular cartilage was higher and the inhibition of synovial proliferation was better, and serum IL-17, IL-1β, and TNF-α levels were lower. We found that the protein level of SIRT1 in peripheral blood mononuclear cells was lower, the protein level in spleen was higher, and phosphorylation of p65 protein in peripheral blood mononuclear cells was reduced. Conclusions The efficacy of tail vein injection of IL-10-modified BMSCs in treatment of CIA rats was superior to that of BMSCs alone, which may be related to the more pronounced suppression of IL-10-modified BMSCs in peripheral blood inflammation and spleen immune response.

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“…The role of lncRNAs in HCV-infected patients has overlooked extrahepatic manifestations despite evidence pointing to the contrary. A good example is lncRNA-AF085935, which has been recently described to have potential as an early marker of rheumatoid arthritis [105]. In the liver, few studies have focused on lncRNAs related to HCV-induced fibrosis.…”

Section: Lncrnas Related To Extrahepatic Manifestations and Hcv-relatmentioning

confidence: 99%

LncRNAs in HCV Infection and HCV-Related Liver Disease

Unfried¹,

Fortes²

2020

IJMS

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Long non-coding RNAs (lncRNAs) are transcripts with poor coding capacity that may interact with proteins, DNA, or other RNAs to perform structural and regulatory functions. The lncRNA transcriptome changes significantly in most diseases, including cancer and viral infections. In this review, we summarize the functional implications of lncRNA-deregulation after infection with hepatitis C virus (HCV). HCV leads to chronic infection in many patients that may progress to liver cirrhosis and hepatocellular carcinoma (HCC). Most lncRNAs deregulated in infected cells that have been described function to potentiate or block the antiviral response and, therefore, they have a great impact on HCV viral replication. In addition, several lncRNAs upregulated by the infection contribute to viral release. Finally, many lncRNAs have been described as deregulated in HCV-related HCC that function to enhance cell survival, proliferation, and tumor progression by different mechanisms. Interestingly, some HCV-related HCC lncRNAs can be detected in bodily fluids, and there is great hope that they could be used as biomarkers to predict cancer initiation, progression, tumor burden, response to treatment, resistance to therapy, or tumor recurrence. Finally, there is high confidence that lncRNAs could also be used to improve the suboptimal long-term outcomes of current HCC treatment options.

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Role of LncRNA-AF085935, IL-10 and IL-17 in Rheumatoid Arthritis Patients With Chronic Hepatitis C

Cited by 11 publications

References 59 publications

Retracted: Long non‐coding RNA XIST binding to let‐7c‐5p contributes to rheumatoid arthritis through its effects on proliferation and differentiation of osteoblasts via regulation of STAT3

Retracted: Long non‐coding RNA XIST binding to let‐7c‐5p contributes to rheumatoid arthritis through its effects on proliferation and differentiation of osteoblasts via regulation of STAT3

Treatment of Type II Collagen-Induced Rat Rheumatoid Arthritis Model by Interleukin 10 (IL10)-Mesenchymal Stem Cells (BMSCs)

LncRNAs in HCV Infection and HCV-Related Liver Disease

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