Role of LIBS in Elemental Analysis ofPsidium guajavaResponsible for Glycemic Potential

Abstract

The present study deals with the detection of elements responsible for glycemic potential of ripe and unripe fruit peel aqueous extracts of Psidium guajava (P. guajava). Treatment with the aqueous extract of unripe fruit peel showed a significant fall of 17.5% (p , 0.001) in blood glucose levels (BGLs) of normal rats during fasting blood glucose (FBG) test with a dose of 400 mg/kg bw. In sub-diabetic rats, a fall of 19.8% (p , 0.001) was observed with the same dose during a glucose tolerance test (GTT). The significant fall observed in FBG, post prandial glucose (PPG) and urine sugar levels of severely diabetic rats was 20.7%, 17.5% (p , 0.05), and 66.6% (p , 0.01), respectively. On the contrary, the effect of ripe fruit peel aqueous extract showed a regular rise of 24.4% (p , 0.01) in BGL of normal rats and of 90.0% (p , 0.001) in sub-diabetic rats. Laser Induced Breakdown Spectroscopy (LIBS) has been used for the identification of elements responsible for the glycemic potential of fruit peel aqueous extracts of P. guajava.

Antidiabetic effect of Withania coagulans in experimental rats

“…The identified hypoglycemic and antidiabetic potential of fruits of W. coagulans may to be due to the significant presence of Mg (13) and Ca (14) in the extract. Since, Boltzmann distribution law states that intensity is proportional to the concentration.…”

Curative effect of Cynodon dactylon against STZ induced hepatic injury in diabetic rats

“…The popularity of plant-based drug in the modern system of medicine is growing day by day as they are claimed to be safe, economical and yet efficacious (1)(2)(3). The adverse drug reaction of synthetic medicines in the treatment of diabetes mellitus has restricted in a growing demand for the use of herbal drug or Phytomedicines (4).…”

The Glycemic Elemental Profile of Trichosanthes dioica: A LIBS-Based Study

“…29 Recently, we have found in our lab that Mg and Ca manage the blood glucose levels and also restore the antioxidant activity in type 2 diabetic rats. [30][31][32][33][34] From the outcome of this study, it can be conclusively stated that the higher concentrations of Ca ++ , Mg ++ , and Fe ++ , as reflected by their intensities, are responsible for glycemic potential of T. dioica. Further studies to establish the absolute concentrations of trace elements needed for optimum glycemic activity in diabetic management are in progress.…”