Role of laxative and antioxidant properties of Malva sylvestris leaves in constipation treatment

Jabri, Mohamed-Amine; Wannes, Dalanda; Hajji, Najla; Sakly, Mohsen; Marzouki, Lamjed; Sebaï, Hichem

doi:10.1016/j.biopha.2017.02.020

Cited by 46 publications

(28 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In colonic mucosa, the oxidative stress conditions were assessed by an increase of MDA and H 2 O 2 production. These effects were accompanied with perturbation of enzymatic and nonenzymatic antioxidants [19].…”

Section: Oxidative Stress In Constipationmentioning

confidence: 99%

Implication of Oxidative Stress in Small Intestine Disorders, Constipation and Diarrhea: A Mini Review

Rtibi¹,

Amri²,

Sebaï³

et al. 2017

Recent Advances in Biology and Medicine

Self Cite

View full text Add to dashboard Cite

Diarrhea pathophysiology and constipation are multifactorial gastrointestinal (GI) disorders characterized by intestinal peristalsis disruption of and an irregularity in secretion/absorption process. Oxidative stress, as an imbalance in prooxidants/antioxidants, has recently been recognized as a significant player in these GI disturbances. In this respect, numerous studies were performed and have shown that the deleterious effects on GI tract were accompanied by accumulation of oxidants and depletion of antioxidant system. Antioxidant remedy is necessary in scavenging free radicals and reactive oxygen species preventing oxidative stress-induced GI interruptions.

show abstract

Section: Oxidative Stress In Constipationmentioning

confidence: 99%

Implication of Oxidative Stress in Small Intestine Disorders, Constipation and Diarrhea: A Mini Review

Rtibi¹,

Amri²,

Sebaï³

et al. 2017

Recent Advances in Biology and Medicine

Self Cite

View full text Add to dashboard Cite

show abstract

“…Jabri and his colleagues. 323 They induced constipation in rats by loperamide (Figure 8), a synthetic alkaloid, usually marketed as the commercial Imodium for diarrhea relief. Constipation was successfully treated with aqueous extract of M. sylvestris leaves.…”

Section: New Compoundsmentioning

confidence: 99%

“…322 Constipation in rats was induced by loperamide and treared with leaves aqueous exreact and yohimbine as control laxative (see Figure 8) 323 Mouth and throat diseases A herbal mouthwash consisting of Althaea officinalis, Salix alba and M. sylvestris leaves (ratio, 5:1.25:1, respectively). Leaves extracted with ethanol and the dry extract was suspended with water (0.31%).…”

Section: Constipation Reliefmentioning

confidence: 99%

Malva: Food, Medicine and Chemistry

Azab¹

2017

ECB

View full text Add to dashboard Cite

“…However, high costs and adverse reactions limit their use in the treatment of constipation. Prokinetic agents, especially Tigacelo, are still commonly used today as laxatives, but are prone to life-threatening coronary artery constriction and myocardial infarction [8].…”

Section: Introductionmentioning

confidence: 99%

The water-eluting component of Anemarrhena asphodeloides Bge. laxative effects on loperamide-induced constipation rats

Li¹,

Liu²,

Sun³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Slow transit functional constipation (STC) is the most common type of chronic constipation,with seriously affecting people's survival and quality of life in the recent years. Based on the safety and small side effects of traditional Chinese medicine, it is urgent to research and develop new medicine for the treatment of constipation. As a traditional Chinese medicine, Anemarrhena asphodeloides Bge. has been reported treat constipation in a long time, and carbohydrate is its active ingredient. Methods ELISA used for detection of serum gastrointestinal hormones and neurotransmitters levels. HE stain was analyzed to evaluate the colon injury. Western blot and RT-PCR detected interstitial cells of Cajal markers (SCF/c-Kit) and aquaporins (AQPs). Results The mainly compositions of oligosaccharide and amino acid from AABW was determined by HPLC. Based on the laxative activities of AABW in the study, AABW obviously enhanced the contents of VIP, Gas, MTL, SP and 5-HT and decreased the levels of NO from loperamide-induced rats by Elisa kits. Additionally, AABW could up-regulate the expressions of SCF, c-Kit, AQP3, VIP and down-regulate AQP8 to repair the damage of colon. Conclusion These findings suggested that AABW, which could treat constipation through mediating intestinal motility and water metabolism, were laxative active constituents from Anemarrhena asphodeloides Bge..

show abstract

Role of laxative and antioxidant properties of Malva sylvestris leaves in constipation treatment

Cited by 46 publications

References 45 publications

Implication of Oxidative Stress in Small Intestine Disorders, Constipation and Diarrhea: A Mini Review

Implication of Oxidative Stress in Small Intestine Disorders, Constipation and Diarrhea: A Mini Review

Malva: Food, Medicine and Chemistry

The water-eluting component of Anemarrhena asphodeloides Bge. laxative effects on loperamide-induced constipation rats

Contact Info

Product

Resources

About