1996
DOI: 10.1002/hep.510240135
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Role of Kupffer Cells and the Spleen in Modulation of Endotoxin–Induced Liver Injury After Partial Hepatectomy

Abstract: The hypothesis that both activated Kupffer cells and the spleen may be responsible for endotoxin-induced liver injury following partial hepatectomy was investigated. Male rats were divided into a sham group receiving laparotomy alone and three groups receiving a two-thirds hepatectomy; one group was given normal saline (NS) solution as a vehicle control, one group received intravenous gadolinium chloride (GC group) (7 mg/kg body weight) for 2 days before intravenous injection of endotoxin to inhibit Kupffer ce… Show more

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Cited by 84 publications
(81 citation statements)
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“…In addition to its ability to clear LPS, the liver also responds to LPS and produces cytokines. LPS directly causes liver injury by mechanisms involving inflammatory cells such as Kupffer cells, and chemical mediators such as superoxide, nitric oxide, and tumor necrosis factor (TNFa) and other cytokines [31,81,91]. In addition, LPS potentiates liver damage induced by hepatotoxins including ethanol [10,19,30,46,59,84].…”
Section: Kupffer Cells and Alcoholic Liver Diseasementioning
confidence: 99%
“…In addition to its ability to clear LPS, the liver also responds to LPS and produces cytokines. LPS directly causes liver injury by mechanisms involving inflammatory cells such as Kupffer cells, and chemical mediators such as superoxide, nitric oxide, and tumor necrosis factor (TNFa) and other cytokines [31,81,91]. In addition, LPS potentiates liver damage induced by hepatotoxins including ethanol [10,19,30,46,59,84].…”
Section: Kupffer Cells and Alcoholic Liver Diseasementioning
confidence: 99%
“…The scope of elevation is related to the endotoxin concentration, positive correlation in certain range (Wang et al, 1996). The cytokines and inflammatory mediators released by the activated cell Kupffer are more important than the direct effect of endotoxin in the hepatic injury (Fujita et al, 1995;Suzuki et al, 1996). Liver is the main endotoxin-eliminating organ while cell Kupffer is the hepatic component with that function.…”
Section: Role Of Endotoxinmentioning
confidence: 99%
“…This response is deleterious to the liver regeneration process and the main mechanisms involved in its physiopathology are shear stress response, neutrophilic migration and endothelial damage [7][8][18][19] .…”
Section: Discussionmentioning
confidence: 99%