Role of intravenous tranexamic acid for the reduction of blood loss in total knee arthroplasty

Chaudhary, Deepinder; Kumar, Pawan; Mehrotra, Ravi; Bhathal, Manrattan

doi:10.22271/ortho.2017.v3.i4h.76

Cited by 1 publication

(1 citation statement)

References 16 publications

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“…Over the years with improvement of surgical techniques various method of control ling bleeding or cauterization have been popularized which includes the use of tourniquet, cauterization, antifibrinolytic agents Epsilon amino caproic acid an artificial analogue of lysine having a strong inhibiting effect on plasminogen and Trans 4 amino methylcyclohexane carboxylic acid well known as tranexamic acid , have been widely used clinically over last few years to control bleeding The efficacy of tranexamic acid has been reported to be 10 times more than Epsilon amino caproic acid and more tolerable when compared to Epsilon aminocaproic acid (9). Kazi et al in the year 2012 assessed the tranexamic acid efficacy in reducing transfusions required in patients that underwent revision hip replacement surgery.…”

Section: Literature Reviewmentioning

confidence: 99%

A Study on Efficacy of Tranexamic Acid in Reducing Blood Loss in Total Hipreplacement Surgery

Tomar,

Juyal,

Khera

2023

J. Adv. Zool.

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Background: The purpose of this study was to assess tranexamic acid effectiveness in lowering perioperative blood loss in total hip arthroplasty. Materials and Methods: Two groups with a total of sixty patients were created. tranexamic acid was administered preoperatively to patients in Group A. patients in Group B did not receive tranexamic acid. Intraoperative blood loss, preoperative, postoperative hemoglobin were monitored and documented. Results: The following observations were made: patients in the study were in the age group of 20-70 years age. Majority patients belonged to 20-50 years of age (N=45, 75%). Male to female ratio of the study population was 13:1. mean weight of the study population was 57.35 kg. Out of the various preoperative diagnosis majority of the patients were diagnosed with avascular necrosis with secondary osteoarthritis (55%). 37 patients underwent Non cemented total hip replacement, 21 underwent cemented total hip replacement and 2 patients underwent Hybrid total hip replacement. Conclusion: Intraoperative blood loss was less in tranexamic acid group compared to control group (172 ml) p value (0.001). Postoperative fall in hemoglobin was less in tranexamic acid group compared to control group (0.510 g/dl) p value (0.016).

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Section: Literature Reviewmentioning

confidence: 99%