A Study on Efficacy of Tranexamic Acid in Reducing Blood Loss in Total Hipreplacement Surgery

Abstract

Background: The purpose of this study was to assess tranexamic acid effectiveness in lowering perioperative blood loss in total hip arthroplasty. Materials and Methods: Two groups with a total of sixty patients were created. tranexamic acid was administered preoperatively to patients in Group A. patients in Group B did not receive tranexamic acid. Intraoperative blood loss, preoperative, postoperative hemoglobin were monitored and documented. Results: The following observations were made: patients in the study were in the age group of 20-70 years age. Majority patients belonged to 20-50 years of age (N=45, 75%). Male to female ratio of the study population was 13:1. mean weight of the study population was 57.35 kg. Out of the various preoperative diagnosis majority of the patients were diagnosed with avascular necrosis with secondary osteoarthritis (55%). 37 patients underwent Non cemented total hip replacement, 21 underwent cemented total hip replacement and 2 patients underwent Hybrid total hip replacement. Conclusion: Intraoperative blood loss was less in tranexamic acid group compared to control group (172 ml) p value (0.001). Postoperative fall in hemoglobin was less in tranexamic acid group compared to control group (0.510 g/dl) p value (0.016).