Role of intravenous lipid emulsions in the management of calcium channel blocker and β-blocker overdose: 3 years experience of a university hospital

Abstract

There was 93.3% survival in patients receiving ILE for drug-induced cardiovascular collapse. Clinically significant adverse effects were uncommon. We suggest ILE administration for the treatment of cardiogenic shock due to CCB and BB overdose.

Experts Consensus Recommendations for the Management of Calcium Channel Blocker Poisoning in Adults

“…Based on possible hemodynamic improvement documented in animal studies ( 51 – 53 ), case series ( 54 , 55 ) and case reports ( 56 , 57 ), the workgroup also suggested the use of lipid-emulsion therapy. However, this is not recommended earlier in therapy in the absence of cardiac arrest, given the inconsistent response and the concern of potentially increasing the absorption of medications still present in the gastrointestinal tract by changing the distribution of the CCB.…”

Kreislaufstillstand in besonderen Situationen

“…Therapieerfolge sind beim Einsatz von Glucagon (50-150 μg/kgKG, [357][358][359][360][361][362][363][364][365][366][367][368][369][370]), hochdosierter Insulin-und Glukosegabe [371][372][373], Lipidemulsionen [374][375][376][377], Phosphodiesterasehemmern [378,379], extrakorporaler Unterstützung und IAPB-Einsatz (intraaortale Ballonpumpe, [380][381][382] …”

Importance of early intervention in verapamil overdose – Case Report and antidotes review

“…Additionally, LET decreases verapamil serum concentration and assists with clearing them [40]. However, this therapy is based mainly on animal studies and case reports [41][42][43]. It is important to remember that this type of treatment may cause various analytical interferences with laboratory tests and methods [44].…”