Role of Intracellular Iron in Switching Apoptosis to Ferroptosis to Target Therapy-Resistant Cancer Stem Cells

Pandrangi, Santhi Latha; Chittineedi, Prasanthi; Chalumuri, Sphoorthi Shree; Meena, Avtar S.; Mosquera, Juan Alejandro Neira; Llaguno, Sungey Naynee Sánchez; Pamuru, Ramachandra Reddy; Mohiddin, G. Jaffer; Mohammed, Arifullah

doi:10.3390/molecules27093011

Cited by 21 publications

(19 citation statements)

References 86 publications

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“…Phosphorylation of the FOXO3a by ERK triggers its degradation and thereby prevents cell cycle arrest by inducing apoptosis by triggering Bim and FasL activation. It is required for proper regulation of the cell cycle via inducing p27kip1 and cyclin D [ 48 ]. As a result, ERK-mediated FOXO3a degradation could enhance cellular survival and proliferation via cell cycle dysregulation.…”

Section: Clinical and Epidemiologic Studies Of Breast Cancer Incidenc...mentioning

confidence: 99%

Role of Lipoproteins in the Pathophysiology of Breast Cancer

et al. 2022

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Breast cancer is one of the most common malignancies in women and the leading cause of cancer mortality. Hypercholesterolemia and obesity are potential risk factors for the incidence of breast cancer, and their detection can enhance cancer prevention. In this paper, we discuss the current state of investigations on the importance of lipoproteins, such as low denisity lipoproteins (LDL) and high density lipoproteins (HDL), and cholesterol transporters in the progression of breast cancer, and the therapeutic strategies to reduce breast cancer mortality. Although some research has been unsuccessful at uncovering links between the roles of lipoproteins and breast cancer risk, major scientific trials have found a straight link between LDL levels and incidence of breast cancer, and an inverse link was found between HDL and breast cancer development. Cholesterol and its transporters were shown to have significant importance in the development of breast cancer in studies on breast cancer cell lines and experimental mice models. Instead of cholesterol, 27-hydroxycholesterol, which is a cholesterol metabolite, is thought to promote propagation and metastasis of estrogen receptor-positive breast cancer cell lines. Alteration of lipoproteins via oxidation and HDL glycation are thought to activate many pathways associated with inflammation, thereby promoting cellular proliferation and migration, leading to metastasis while suppressing apoptosis. Medications that lower cholesterol levels and apolipoprotein A-I mimics have appeared to be possible therapeutic agents for preventing excessive cholesterol’s role in promoting the development of breast cancer.

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Section: Clinical and Epidemiologic Studies Of Breast Cancer Incidenc...mentioning

confidence: 99%

Role of Lipoproteins in the Pathophysiology of Breast Cancer

et al. 2022

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“…Studies on the cytotoxicity of CTX have mainly focused on apoptosis [ 7 , 25 ]. However, many studies have found that ferroptosis and apoptosis are closely linked, that apoptosis can be converted into ferroptosis under certain conditions, and that ferroptosis promotes cell sensitivity to apoptosis [ 26 , 27 ]. Hu et al found that apoptosis, pyroptosis, and ferroptosis together induced an immunosuppressive hepatocellular carcinoma microenvironment and γδ T-cell imbalance [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Polysaccharide of Atractylodes macrocephala Koidz Alleviates Cyclophosphamide-Induced Thymus Ferroptosis in Gosling

Zhou

Cao

et al. 2022

Animals

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The present study aimed to explore the mechanism by which PAMK alleviates cyclophosphamide (CTX)-induced ferroptosis in thymocytes. One-day-old goslings were divided into four groups (10 goslings/group). The CON and CTX groups were fed a basic diet. The PAMK and CTX + PAMK groups were fed the basic diet mixed with PAMK (400 mg/kg). Moreover, the CTX and CTX + PAMK groups were given a daily injection of 40 mg/kg BW of CTX (at 19, 20, and 21 days of age). On the other hand, the CON and PAMK groups were given 0.5 mL of sterilized saline into the leg muscle (at 19, 20, and 21 days of age). The goslings were fed for 28 days. The ferroptosis pathway was enriched in transcriptome sequencing. Compared to the CON group, the thymus in the CTX group underwent injury, and the mitochondria of thymocytes showed features of ferroptosis. PAMK treatment alleviated ferroptosis in thymocytes and thymus injury, and CTX-induced elevated levels of oxidative stress and iron content restored GPX4 protein expression (p < 0.05) and inhibited the CTX-induced activation of the ferroptosis pathway (p < 0.05). Conclusively, PAMK could reduce thymus injury by alleviating CTX-induced thymocyte ferroptosis in gosling to alleviate the immunosuppression caused by CTX in the organism.

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“…The major cause of skin ovary cancer is still understudy because most of studies are going on this issue to calculate the exact reason of developing these tumors. They are also still confused about the main reason of ovary cancer because not much points are getting related with the cancer stem cells [12]. By using different phenotype effects, they also take some cells from ovary to study the level of cancer cells present.…”

Section: Discussionmentioning

confidence: 99%

A Study of Cancer of Ovaries among Women and it’s Linked with the Stem Cells present in Body: A Review

John¹,

Anthony²,

Bhatti³

2022

PJMHS

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Background: Ovarian cancer (OC) is the seventh most commonly diagnosed cancer among women in the world. A woman’s lifetime risk of developing OC is 1 in 75, and her chance of dying of the disease is 1 in 100.Cells which initiate cancer cells in the body are somehow known as stem cells. Objective: The objective of this review was to evaluate the published literature on epidemiologic risk factors for ovarian cancer among women and it’s linked with the stem cells present in the body. Material and methods: A review of literature search was conducted in PubMed and Scopus. Studies comparing ovarian cancer among women and its linked with the stem cells present in the body were included. Results: Eight of 94 articles met the inclusion criteria. The articles revealed that there are no rules to separate out the cells which are spreading tumor cells or in short from this research they said that we are not able to separate them out but we can clarify the issue that either they are spreading this deadly disease or not. Stem cells are not linked with ovarian cancer. Conclusion: It is concluded that phonetically both cancer cells and stem cells are not same. They are showing their opposite impacts. In this study we have seen that first they initiate from a single cell and then start replicating and make groups. There are many other ways through which tumor cells can generate themselves so it is not easy to say that they are growing from stem cells. Keywords: Ovarian cancer, Stem cells and Women

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Role of Intracellular Iron in Switching Apoptosis to Ferroptosis to Target Therapy-Resistant Cancer Stem Cells

Cited by 21 publications

References 86 publications

Role of Lipoproteins in the Pathophysiology of Breast Cancer

Role of Lipoproteins in the Pathophysiology of Breast Cancer

Polysaccharide of Atractylodes macrocephala Koidz Alleviates Cyclophosphamide-Induced Thymus Ferroptosis in Gosling

A Study of Cancer of Ovaries among Women and it’s Linked with the Stem Cells present in Body: A Review

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