Role of interleukin-6 in regulating synthesis of C-reactive protein and serum amyloid A in human hepatoma cell lines

Ganapathi, Mahrukh K.; May, Lester T.; Schultz, Debra A.; Brabenec, Anne; Weinstein, Joel A.; Sehgal, Pravinkumar B.; Kushner, Irving

doi:10.1016/s0006-291x(88)80043-3

Cited by 149 publications

(107 citation statements)

References 23 publications

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“…In the latter cell type, no stimulation by LIF was detectable, most likely due to the fact that these cells are nonresponsive to that factor (A. Mackiewicz and H. Baumann, unpublished data). Nevertheless, the Hp sequence showed a pattern of cytokine regulation that was a mirror image of that achieved with the elements from the C-reactive protein gene, the only molecularly characterized human type 1 acute-phase protein described so far (3,20,21,32).…”

Section: Resultsmentioning

confidence: 91%

Distinct regulation of the interleukin-1 and interleukin-6 response elements of the rat haptoglobin gene in rat and human hepatoma cells.

Morella¹,

Jahreis²,

Marinković³

1990

Mol. Cell. Biol.

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Section: Resultsmentioning

confidence: 91%

Distinct regulation of the interleukin-1 and interleukin-6 response elements of the rat haptoglobin gene in rat and human hepatoma cells.

Morella¹,

Jahreis²,

Marinković³

1990

Mol. Cell. Biol.

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“…These results led to the assumption that SAA might be regarded as a marker to monitor tumor progression and might have prognostic value for several types of malignancies. According to the previous studies, human hepatoblastoma HepG2 cell lines (Steel et al, 1996) and various hepatocellular carcinoma cell lines, DOI:http://dx.doi.org/10.7314/APJCP.2014.15.24.10713 Prognostic Significance of Serum Amyloid A for Hepatocellular Carcinoma such as Hep3B, HuH-7, and NPLC/PRF/5, constitutively synthesized SAA in steady state and were capable to accumulate increased level of SAA in response to various inflammatory mediators at the RNA and protein levels (Ganapathi et al, 1988;Thorn et al, 2003;Thorn et al, 2004). Moreover, immunohistochemistry analysis showed that the SAA protein expression only accumulates in the hepatocellular carcinoma cell without reinforcement of the staining in inflammatory cells, nor in hepatocytes around (Bioulac-Sage et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Serum Amyloid A is a Novel Prognostic Biomarker in Hepatocellular Carcinoma

Ni¹,

Ye²,

Fu³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Purpose: To investigate the prognostic value of serum amyloid A (SAA) in patients with hepatocellular carcinoma (HCC) undergoing surgery. Materials and Methods: Preoperative serum samples of 328 patients with HCC who underwent curative resection and of 47 patients with benign liver lesion were assayed. Serum levels of SAA were measured by enzyme-linked immunosorbent assay and its correlations with clinicopathological characteristics and survival were explored. Results: Levels of SAA were significantly higher in patients with HCC than those with benign liver lesion. There were strong correlations between preoperative serum SAA level and tumor size and more advanced BCLC stage. On univariate analysis, elevated SAA was associated with reduced disease-free survival and overall survival (p=0.001 and 0.03, respectively). Multivariate analyses showed that serum SAA level was an independent prognostic factor for overall survival (hazard ratio 2.80, p=0.01). Conclusions: High SAA serum level is a novel biomarker for the prognosis of HCC patients.

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“…2,3,12 It is well known that IL-1b and IL-6 induce the expression of serum amyloid A in hepatocytes and hepatocellular carcinoma cell lines; 13 however, there is no study addressing the expression of serum amyloid A in hepatocellular carcinoma and benign hepatocellular nodules such as focal nodular hyperplasia, to our knowledge. This study disclosed for the first time that immunoreactivity for serum amyloid A was seen in benign and malignant hepatocellular nodules to various degrees.…”

Section: Discussionmentioning

confidence: 99%

A serum amyloid A-positive hepatocellular neoplasm arising in alcoholic cirrhosis: a previously unrecognized type of inflammatory hepatocellular tumor

et al. 2012

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Hepatocellular adenoma usually arises in the absence of significant fibrosis. Herein, we report seven patients with serum amyloid A-positive hepatocellular neoplasm, which shares features with inflammatory hepatocellular adenoma arising in alcoholic cirrhosis. Seven patients (two women and five men, age range 41-67 years) with hypervascular hepatocellular nodules associated with alcoholic cirrhosis were retrieved from our pathological files (1997)(1998)(1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011). The hepatocellular nodules were multiple (43) in all patients and 17 nodules were histologically examined. We surveyed the immunoreactivity for serum amyloid A, glutamine synthetase, and glypican-3 in the hepatocellular nodules and control lesions, including 5 focal nodular hyperplasia, 18 dysplastic nodules, and 54 hepatocellular carcinomas in various background diseases. In all, 15 of 17 nodules showed strong and distinct immunoreactivity for serum amyloid A, sharing features with inflammatory hepatocellular adenoma. The serum amyloid A-positive hepatocellular neoplasms showed increased cellular density, inflammatory infiltrate, sinusoidal dilatation, and ductular reaction to various degrees. Although about a half of dysplastic nodules and hepatocellular carcinomas showed focal immunoreactivity for serum amyloid A, the extent of serum amyloid A expression was significantly higher in serum amyloid A-positive hepatocellular neoplasms, than in control nodules. The serum amyloid A-positive hepatocellular neoplasms did not show the overexpression of glutamine synthetase or immunoreactivity for glypican-3. In contrast, most hepatocellular carcinomas showed the overexpression of glutamine synthetase and immunoreactivity for glypican-3, irrespective of background diseases. In conclusion, this study highlights a characteristic group of hepatocellular neoplasms arising in alcoholic cirrhosis, which share features with inflammatory hepatocellular adenomas. These serum amyloid Apositive hepatocellular neoplasms may be a new type of inflammatory hepatocellular tumors in alcoholic patients.

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Role of interleukin-6 in regulating synthesis of C-reactive protein and serum amyloid A in human hepatoma cell lines

Cited by 149 publications

References 23 publications

Distinct regulation of the interleukin-1 and interleukin-6 response elements of the rat haptoglobin gene in rat and human hepatoma cells.

Distinct regulation of the interleukin-1 and interleukin-6 response elements of the rat haptoglobin gene in rat and human hepatoma cells.

Serum Amyloid A is a Novel Prognostic Biomarker in Hepatocellular Carcinoma

A serum amyloid A-positive hepatocellular neoplasm arising in alcoholic cirrhosis: a previously unrecognized type of inflammatory hepatocellular tumor

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