Role of Interleukin-10 Gene Promoter Region Polymorphism in the Development of Chronic Lymphoid Leukemia

Ovsepyan, V. A.; Gabdulkhakova, A. Kh.; Shubenkiva, A. A.; Зотина, Е. Н.

doi:10.1007/s10517-015-3148-6

Cited by 12 publications

(12 citation statements)

References 11 publications

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“…The details of eligible studies are presented in Table 1 . Most studies were performed in non-Chinese ethnicity, [ 13 , 17 – 29 ] with 4 studies in Chinese population. [ 14 , 30 – 32 ] We found that controls in 6 studies were not consistent with Hardy-Weinberg equilibrium [ 14 , 17 , 18 , 24 , 29 , 30 ] maybe because of genotyping error or selection bias during controls’ recruitment.…”

Section: Resultsmentioning

confidence: 99%

“…SNPs in the transcriptional start area of IL-10 gene influence the production of IL-10 thus may increase or decrease the risk of cancers, [ 10 – 12 ] including leukemia, but the conclusions are inconsistent. For example, Ovsepyan, V. A. et al [ 13 ] found SNP in the IL-10 -1082A/G was associated with the risk of chronic lymphoid leukemia, while Lo, W. J. et al [ 14 ] found no association between IL-10 -1082A/G and leukemia. Conflicting results may be due to small sample size.…”

Section: Introductionmentioning

confidence: 99%

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The single nucleotide polymorphisms of interleukin-10 are associated with the risk of leukaemia

et al. 2020

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Interleukin-10(IL-10) is an immunosuppressive cytokine and plays an important role in inflammation and cancers. Numerous studies have explored the association between single nucleotide polymorphisms of IL-10 and leukemia, but their results were conflicting, so we performed this meta-analysis to elucidate the association between 3 common single nucleotide polymorphisms of IL-10 (rs1800896, rs1800871 and rs1800872) and risk of leukemia. We conducted a comprehensive research in Pubmed, Chinese Biomedical Literature Database disc and Embase using related terms. After strict selection, 18 studies with 2264 cases and 3846 controls were included into this meta-analysis. Odds ratio and 95% confidence interval were used to evaluate the strength of the association. We found that polymorphism of IL-10 -1082A/G was associated with decreased risk of leukemia both in overall analysis and in stratified analysis according to ethnicity and cancer type. A strong relationship was also uncovered between polymorphism of IL-10 -592C/A and increased risk of leukemia in non-Chinese. GG genotype of IL-10 -1082A/G is associated with decreased risk of leukemia, especially chronic lymphocytic leukemia. CC genotype of -592C/A is associated with decreased risk of leukemia in non-Chinese.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The single nucleotide polymorphisms of interleukin-10 are associated with the risk of leukaemia

et al. 2020

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“…Furthermore, this allele may be a marker which correlates with worse prognosis, fast progression of the disease and short TFS (Lech-Maranda et al, 2013). On contrast, Ovsepyan et al shown single nucleotide replacement-1082G>A in IL-10 gene promoter region is probable genetic factor of CLL risk and of disease manifestation at advanced stages (Ovsepyan et al, 2015).…”

Section: Interleukin-10-1082a>g (Rs1800896) Single Nucleotidementioning

confidence: 97%

“…Recently, a series of epidemiological studies have focused on the association between these SNPs of IL-10 (-3575T>A, -1082A>G,-819C>T and -592C>A) and the risk of CLL (Domingo-Domènech et al, 2007;Ennas et al, 2008;Lech-Maranda et al, 2008;Lech-Maranda et al, 2013;Ovsepyan et al, 2015).…”

Section: Interleukin-10-1082a>g (Rs1800896) Single Nucleotidementioning

confidence: 99%

Interleukin-10-1082A>G (rs1800896) Single Nucleotide Polymorphism is Not a Risk Factor of Chronic Lymphocytic Leukemia in Sudanese Population

Basabaeen

Abdelgader

Ahmed

et al. 2022

Asian Pac J Cancer Prev

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Objective: The present study was conducted to examine the association between the IL-10-1082A>G (rs 1800896) polymorphism and risk of Chronic Lymphocytic Leukemia and to assess the correlation between this polymorphism and clinicopathological characters. Methods: A case-control study was conducted in Khartoum state, Sudan, during the period from April 2017 to April 2018, involved 110 CLL patients and 80 healthy volunteers as a control group. Physical examination, complete blood count, and immunophenotype were performed in all patients to confirm the diagnosis. Clinical staging such as Rai and Binet were studied. CD38 and ZAP70 were performed by flow cytometry. Blood samples were collected from all participants; DNA was extracted by using ANALYTIKJENA Blood DNA Extraction Kit and analyzed IL-10-1082A>G polymorphism by using Allele Specific-Polymerase Chain Reaction. The statistical analysis was performed using statistical package for social sciences version 23.0 software. Results: Frequency of AA, AG, and GG genotypes was 32.7%, 55.5%, and 11.8% for the patient group and 31.25%, 51.25%, and 17.5% in the control group, respectively. The genotype of IL-10 (-1082A>G) did not associate with susceptibility of CLL in our population. The study showed that the G allele of the IL-10 gene (-1082A>G) is associated with the male sex. However, no significant association was found between -1082A>G genotype and clinicopathological characters. Conclusion: Our results do not support the involvement of the IL-10 −1082A>G promoter gene polymorphism in the increased CLL susceptibility. IL-10-1082G allele (IL-10-1082AG or IL-10-1082GG) was found more frequently in males. Furthermore, no association was observed between the IL-10-1082A>G polymorphism and clinical stages systems as well as established poor prognostic markers. Finally, within the group of patients with CLL, there was no difference in the age at diagnosis and hematological parameters according to genotype distributions.

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“…Epidemiological research studies have showed that the addition of flavonoids can reduce the risk of cardiovascular disease [4]. Ovsepyan found that macrophages secreted large amounts of C-reactive protein (CRP) and TNFα, IL-6, and other proinflammatory factors, promoting the apoptosis of smooth muscle cell and the development of atherosclerosis [5]. Coronary artery bypass surgery (CABG) has become a common cardiac surgery treatment for patients with coronary heart disease (CHD).…”

Section: Introductionmentioning

confidence: 99%

Quercetin Relieves the Excised Great Saphenous Vein Oxidative Damage and Inflammatory Reaction

Bai

Chen

Zhu

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Objective. The patency and quality of transplanted great saphenous vein (GSV) can seriously influence the physical state and life quality of patients who accepted the coronary artery bypass grafting (CABG). Quercetin is known for antioxidant, antithrombotic, anti-inflammatory, and antitumor properties. In this study, we examined the protection of quercetin to the great saphenous vein from oxidative and inflammatory damage. Methods. The GSVs were collected from 15 patients undergoing CABG and cultured. Treated the veins by H2O2 and detected the NO, SOD, and MDA content by the relevant kits to explore the quercetin protection against oxidative damage. Then, for another group of GSVs, sheared them and detected the inflammatory cytokines, such as IL-6, TNFα, CCL20, PCNA, and VEGF. Collect the veins for H&E staining and PCNA and VEGF immunofluorescent staining. Results. Pretreatment by quercetin reduced the production of NO and MDA induced by H2O2, and increased SOD activity. Quercetin also supressed the mRNA expressions of IL-6, TNFα after mechanical damage and had no influence on CCL20 and VEGF. Consistent with the lower expression of PCNA treated by quercetin, the vein intima was thinner. Conclusion. These results demonstrated that quercetin protects GSVs by reducing the oxidative damage and inflammatory response and also suppresses the abnormal thickening of venous endothelium by inhibiting cell proliferation. It reminded that, to some extent, quercetin has the potential to release the great saphenous vein graft damage.

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Role of Interleukin-10 Gene Promoter Region Polymorphism in the Development of Chronic Lymphoid Leukemia

Cited by 12 publications

References 11 publications

The single nucleotide polymorphisms of interleukin-10 are associated with the risk of leukaemia

The single nucleotide polymorphisms of interleukin-10 are associated with the risk of leukaemia

Interleukin-10-1082A>G (rs1800896) Single Nucleotide Polymorphism is Not a Risk Factor of Chronic Lymphocytic Leukemia in Sudanese Population

Quercetin Relieves the Excised Great Saphenous Vein Oxidative Damage and Inflammatory Reaction

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