The single nucleotide polymorphisms of interleukin-10 are associated with the risk of leukaemia

Abstract

Interleukin-10(IL-10) is an immunosuppressive cytokine and plays an important role in inflammation and cancers. Numerous studies have explored the association between single nucleotide polymorphisms of IL-10 and leukemia, but their results were conflicting, so we performed this meta-analysis to elucidate the association between 3 common single nucleotide polymorphisms of IL-10 (rs1800896, rs1800871 and rs1800872) and risk of leukemia. We conducted a comprehensive research in Pubmed, Chinese Biomedical Literature Database disc and Embase using related terms. After strict selection, 18 studies with 2264 cases and 3846 controls were included into this meta-analysis. Odds ratio and 95% confidence interval were used to evaluate the strength of the association. We found that polymorphism of IL-10 -1082A/G was associated with decreased risk of leukemia both in overall analysis and in stratified analysis according to ethnicity and cancer type. A strong relationship was also uncovered between polymorphism of IL-10 -592C/A and increased risk of leukemia in non-Chinese. GG genotype of IL-10 -1082A/G is associated with decreased risk of leukemia, especially chronic lymphocytic leukemia. CC genotype of -592C/A is associated with decreased risk of leukemia in non-Chinese.

Analysis of Mutational Status of IGHV, and Cytokine Polymorphisms as Prognostic Factors in Chronic Lymphocytic Leukemia: The Romanian Experience

“…In a recent metanalysis by Gao S. et al, a strong association was found between rs1800896 and leukemia in non-Chinese patients, while the result was negative in Chinese patients [49]. In a study conducted by Aref S on a cohort of 50 CLL patients, they found that the variant allele of rs1800896 was significantly associated with advanced stages of CLL (p < 0.001), a short time to first treatment (p = 0.032), shorter progression-free survival (p = 0.044), and a lower response to treatment (p = 0.003) when compared to the wild genotype [23].…”

“…Basabaeen A. et al, on a Sudanese population, again found no association between CLL and rs1800896 [14]. As for rs1800872, in a metanalysis by Gao S., the authors found an association with leukemia risk in non-Chinese patients and no significant association in Chinese patients [49]. The cause of these discordances might lie in the different genetic makeup of the different populations.…”

Prognostic Role of Human Leukocyte Antigen Alleles and Cytokine Single-Nucleotide Polymorphisms in Patients with Chronic Myeloid Leukemia Treated with Tyrosine Kinase Inhibitor Drugs

“…The level and activity of cytokines is attributed to single-nucleotide polymorphisms (SNPs) within the promoter region or other regulatory sequences of cytokine genes, which in turn impact the peripheral levels of cytokines and thus pathogenesis [ 22 , 23 , 24 ]. Population studies have indicated a strong association of SNPs with primary immune thrombocytopenia among Caucasian adults [ 25 ], the risk of leukemogenesis in a non-Chinese population [ 26 ], the severity of autoimmune hemolytic anemias in an Italian population [ 27 ], and the risk and overall survival of diffuse large B cell lymphoma in an Arab population [ 28 ]. These reports emphasize the importance of cytokine gene SNPs across diverse populations, shedding light on the intricacies of homeostasis and disease development as well as HLA allele polymorphism.…”

IL-10 rs1800896 Polymorphism: A Risk Factor for Adult Acute Lymphoblastic Leukemia

“…Similar findings were reported in a meta-analysis of 18 case-control studies. 35 It has been reported that the GG genotype poses a decreased risk of leukemia in comparison to the AG+AA genotype. 35 The current study shows that rs1800896 has no significant associations with age at diagnosis, gender, or subtype of ALL (Table 4).…”

“…35 It has been reported that the GG genotype poses a decreased risk of leukemia in comparison to the AG+AA genotype. 35 The current study shows that rs1800896 has no significant associations with age at diagnosis, gender, or subtype of ALL (Table 4). This finding is consistent with the literature.…”