Role of interferon-gamma (IFN-γ) and IFN-γ receptor 1/2 (IFNγR1/2) in regulation of immunity, infection, and cancer development: IFN-γ-dependent or independent pathway

Ding, Huihui; Wang, Gongfu; Yu, Zhengtao; Sun, Hongqi; Wang, Lu

doi:10.1016/j.biopha.2022.113683

Cited by 31 publications

(24 citation statements)

References 144 publications

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“…IFN‐γ, a soluble cytokine produced by T lymphocytes, macrophages, mucosal epithelial cells or NK cells, plays central roles in the fundamental immunological processes such as inflammatory reaction, cell‐mediated immunity and autoimmunity. Aberrant IFN‐γ expression is intimately associated with multiple human diseases (Ding et al, 2022). It was reported that TNF‐α and IFN‐γ treatment promoted distinct expression of a range of endothelial surface makers (selectins, ICAM‐1, and VCAM‐1) (Jaczewska et al, 2014).…”

Section: Resultsmentioning

confidence: 99%

“…Endothelial cell injury is a critical event in acute inflammatory processes, during which inflammatory cytokines and reactive oxygen metabolites may be involved (Yamaoka et al, 2002). TNF-α, a potent inflammatory cytokine, can induce the expression and release of various (Ding et al, 2022). It was reported that TNF-α and IFN-γ treatment promoted distinct expression of a range of endothelial surface makers (selectins, ICAM-1, and VCAM-1) (Jaczewska et al, 2014).…”

Section: Spectroscopic Characteristicsmentioning

confidence: 99%

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Protective effect of phosphorylated Athyrium multidentatum (Doll.) Ching polysaccharide on vascular endothelial cells in vitro and in vivo

Yin,

Sheng,

Chen

et al. 2023

Chem Biol Drug Des

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The purpose of this study was to prepare phosphorylated Athyrium multidentatum (Doll.) Ching polysaccharide (PPS) and investigate its protective effect on vascular endothelial cells (VECs) in vitro and in vivo and the underlying mechanisms. Sodium tripolyphosphate (STPP) and sodium trimetaphosphate (STMP) were used as phosphorylation reagents and PPS was characterized by Fourier transform infrared (FT‐IR), 13C nuclear magnetic resonance (13C NMR) and 31P nuclear magnetic resonance (31P NMR) spectra. Chemical analysis demonstrated that PPS was composed of mannose, glucosamine, rhamnose, glucuronic acid, galacturonic acid, galactosamine, glucose, galactose, xylose, arabinose, and fucose with a molar ratio of 11.36:0.42:4.03:1.12:1.81:0.26:33.25:24.12:6.85:14.46:2.32 and a molecular weight of 28,837 Da. Results from in vitro and in vivo assays revealed that PPS protected human umbilical vein endothelial cells (HUVECs) against H2O2‐induced oxidative injury and attenuated D‐galactose‐induced VECs damage in mice. RNA sequencing (RNA‐seq) analysis identified 18 differentially expressed genes (DEGs) between D‐galactose‐treated and PPS‐pretreated mice abdominal aorta. A deep analysis of these DEGs disclosed that PPS regulated the expression of genes involved in the functions of vascular endothelium repairment, cell growth and proliferation, cell survival and apoptosis, inflammation, angiogenesis and antioxidant, indicating that these biological processes might play crucial roles in the protective actions of PPS on VECs.

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Section: Resultsmentioning

confidence: 99%

Section: Spectroscopic Characteristicsmentioning

confidence: 99%

Protective effect of phosphorylated Athyrium multidentatum (Doll.) Ching polysaccharide on vascular endothelial cells in vitro and in vivo

Yin,

Sheng,

Chen

et al. 2023

Chem Biol Drug Des

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“…We found that the compound was not able to reduce the secretion of TNF-α, an important cytokine involved in triggering the innate immune response against host invaders [27,28]. The inhibited cytokines are responsible for different biological effects, contributing to the development and progression of inflammatory responses and increasing the response of cells involved in the immune system [29][30][31][32]. Similarly, other studies have already shown the ability of different 1,4-DHP derivatives to inhibit the production of these same pro-inflammatory cytokines in different experimental models, and as in our experiments, the 1,4-DHP derivatives did not reduce TNF-α levels [10,11,33].…”

Section: Groupmentioning

confidence: 98%

Evaluation of the anti‐inflammatory effect of 1,4‐dihydropyridine derivatives

Facchin,

Lubschinski,

Moon

et al. 2023

Fundamemntal Clinical Pharma

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IntroductionInflammation is a physiological event that protects the organism against different factors that lead to loss of tissue homeostasis. Dihydropyridine (DHP) derivatives are heterocyclic compounds known for their different biological activities, including anti‐inflammatory activities.ObjectiveTo evaluate the anti‐inflammatory activity of 1,4‐dihydropyridine (1,4‐DHP) derivatives using anti‐inflammatory models in vitro, in RAW264.7 cells induced by lipopolysaccharide (LPS) and in vivo using the acute lung injury (ALI) model in mice.ResultsFifteen compounds derived from 1,4‐DHP were tested in RAW264.7 cells for their cytotoxic effect and cell viability. Thereafter, only the six compounds that showed the highest cell viability were tested for the production or inhibition of the pro‐inflammatory cytokine interleukin 6 (IL‐6). The best compound (compound 4) was tested for its anti‐inflammatory effects in vitro and in vivo, showing inhibition of nitric oxide (NO), pro‐inflammatory cytokines, increased phagocytic activity, and an increase in IL‐10 in vitro. In in vivo tests, compound 4 also reduces the levels of NO, myeloperoxidase (MPO) activity, leukocyte migration, and exudation, as well as reducing the levels of tumor necrosis factor‐alpha (TNF‐α) and IL‐6 and preventing the loss in the lung architecture.ConclusionThis compound showed important anti‐inflammatory activity, with a significant ability to reduce the production of pro‐inflammatory mediators and increase the phagocytic activity of macrophages and anti‐inflammatory mediator secretion (IL‐10). These findings led us to hypothesize that this compound can repolarize the macrophage response to an anti‐inflammatory profile (M2). Moreover, it was also able to maintain its anti‐inflammatory activity in vivo experiments.

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“…Ряд досліджень вказують на здатність IFN-γ індукувати апоптоз [17,18,19], а також координувати не тільки імунну регуляцію, але й проліферацію клітин. [20].…”

Section: гістологічна характеристикаunclassified

Histological Characteristics of Experimental Wounds of Soft Tissues of the Femur of Rats and the Role of IFN-γ in the Dynamics of their Healing

Іонов¹,

Komisova²

2022

Ukr. ž. med. bìol. sportu

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The purpose of the study was to evaluate the histomorphological changes in samples of the wound canal of the soft tissues of the femur of rats and to study the role of interferon-gamma (IFN-γ) in the dynamics of wound healing. Materials and methods. The study was conducted on 24 Wistar rats. Animals were divided into two groups – intact (6 rats) and experimental (18 rats). Animals of the experimental group were used to simulate wounds. Rats were euthanized on the 10th, 20th, and 40th days (6 animals for each time) after wound simulation. Blood for the study was taken by the method of open cardiac puncture. The levels of INF-γ in the blood serum of animals were determined by enzyme immunoassay. Histological processing of the samples was carried out according to generally accepted methods, the sections were stained with hematoxylin and eosin, as well as picrofuchsin according to Van Gieson. Results and discussion. The work revealed changes in the expression of IFN-γ in the blood serum of animals with wounds: an increase in the levels of IFN-γ on the 10th and 20th days after modeling wounds compared to the levels of rats in the intact group (p<0.05). A decrease in the levels of IFN-γ on the 40th day of the experiment compared to a similar level of this cytokine on the 10th and 20th days after wound simulation was shown (p<0.05). The results of histological studies show signs of the proliferative phase in the form of a significant number of fibroblasts and newly formed vessels, as well as the beginning of the remodeling stage in the form of the organization of collagen fibers in parallel bundles in the wound canals in different areas within 10 days. On the 20th day, the absence of inflammatory cells in the preparations of the damaged areas is noted. Also at the tissue level at this time, signs of the remodeling phase were revealed: a significant decrease in the number of blood vessels and fibroblasts was observed, the connective tissue in the areas acquired a mature appearance in the form of dense layers with single fibrocytes. In the injury zone on the 40th day of the experiment, scars from mature connective tissue were noted. Conclusion. In an experimental study, we showed the morphological and physiological features of the healing of soft tissue injuries in normal rats. The established structural features of wound areas at different stages of healing and the dynamics of IFN-γ release allow us to determine its important role not only in inflammation, but also in the stages of proliferation and remodeling. Determination of the concentration of IFN-γ may be an informative indicator at all stages of repair in the process of healing soft tissue injuries in humans, subjected to further clinical studies

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Role of interferon-gamma (IFN-γ) and IFN-γ receptor 1/2 (IFNγR1/2) in regulation of immunity, infection, and cancer development: IFN-γ-dependent or independent pathway

Cited by 31 publications

References 144 publications

Protective effect of phosphorylated Athyrium multidentatum (Doll.) Ching polysaccharide on vascular endothelial cells in vitro and in vivo

Protective effect of phosphorylated Athyrium multidentatum (Doll.) Ching polysaccharide on vascular endothelial cells in vitro and in vivo

Evaluation of the anti‐inflammatory effect of 1,4‐dihydropyridine derivatives

Histological Characteristics of Experimental Wounds of Soft Tissues of the Femur of Rats and the Role of IFN-γ in the Dynamics of their Healing

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