Role of insulin/glucagon ratio and cell redox state in the hyperglycaemia induced by exposure to a 60-Hz magnetic field in rats

Abstract

The exposure to extremely low-frequency electromagnetic fields (EMFs) could adversely affect the endocrine system and cellular proliferative response. Nonetheless, the use of 60-Hz EMFs in the form of magneto-therapy exerts beneficial actions on human health but can also induce hyperglycaemia. Therefore, the present study was aimed to search for metabolic responses of fed or fasted male rats to a single EMF exposure. We performed a 15 min-single exposure to 60-Hz (3.8 mT, intensity) EMF, and determined serum levels of glucose, lipids, and indicators of cellular redox state and energy parameters. A single exposure to a 60-Hz EMF induced hyperglycaemia in both animal groups, and an attenuated second serum insulin peak. The 60-Hz EMF also decreased free fatty acids and lactate serum levels, oppositely increasing pyruvate and acetoacetate levels. Significant increases in blood glucose level and rat’s glucose metabolism were related to a more oxidized cellular redox state and variations in insulin and glucagon secretion. The 60-Hz EMF’s effects were not modified in animals previously subjected to chronic EMFs exposure (14 days). In conclusion, increased serum glucose levels and glucose metabolism induced by a single 60-Hz EMF exposure were closely related to the cellular redox state and the insulin/glucagon ratio.

Involvement of Liver Redox State in the Zi-Dovudine-Induced Hepatic Steatosis and Its Partial Prevention by Adenosine

“…our group has recently revealed a strong correlation between blood glucose variations, cellular redox state, and the insulin/glucagon ratio [23]. In light of these observations, we quantified the concentrations of pyruvate/lactate and acetoacetate/β-OH-butyrate redox pairs to estimate the NAD/NADH redox state in both the cytoplasm and mitochondria, respectively, and explored their potential reflection in serum levels in our experimental rat model.…”

Lipid profile of blood serum of chickens under conditions of long-term exposure to extremely low frequency variable pulsed electromagnetic field

“…Conversely, external EMFs can modulate an individual's electromagnetic signals, leading to disturbances in electromagnetic homeostasis [7,8]. It is believed that the basis of the occurrence of various types of pathologies is a violation of the resonance of electromagnetic frequencies of the body's cells [7,9,10]. In this regard, the idea of using an artificial MP, which corresponds to the Earth's geomagnetic field in terms of its physical characteristics, to combat the negative consequences of anthropogenic electromagnetic pollution is of particular interest [11].…”