Ca2+ATPase enzyme activities and lipid and protein oxidations of grass carp (Ctenopharyngodon idellus) stored at 4 °C for 30 min under electromagnetic fields

Mahato, Swati; Sun, Da‐Wen; Zhu, Zhiwei

doi:10.1016/j.foodchem.2022.133914

Cited by 18 publications

(2 citation statements)

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“…Both Na + /K + -ATPase and Ca 2+ -ATPase are susceptible to free radical attack and oxidative damage. 28,29 In this study, it was found that the monacolin K treatment decreased both Na + /K + -ATPase and Ca 2+ -ATPase levels in U251 cells. Therefore, we supposed that monacolin K could inhibit antioxidant enzyme activity by releasing free radicals and disrupting the redox equilibrium, thus reducing the activities of Na + /K + -ATPase and Ca 2+ -ATPase in cells.…”

Section: Discussionmentioning

confidence: 62%

Monacolin K Induces Apoptosis of Human Glioma U251 Cells by Triggering ROS-Mediated Oxidative Damage and Regulating MAPKs and NF-κB Pathways

Shi

Huang

et al. 2023

ACS Chem. Neurosci.

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Monacolin K (MK), a polyketo secondary metabolic compound of the mold genus Monascus, can promote the apoptosis of malignant cancer cells, possessing potential antitumor properties. However, its mechanism of action on gliomas remains unclear. Here, we explored and investigated the potential of the monacolin K's antitumor effect on human glioma U251 cells and its possible molecular mechanism. Results showed that the application of 10 μM monacolin K inhibited the proliferation of U251 cells, with an inhibitory rate of up to 53.4%. Additionally, monacolin K induced the generation of reactive oxygen species and activated mitochondria-mediated pathways, including decreased MMP, activation of caspase3/caspase9, decreased Na + /K + -ATPase and Ca 2+ -ATPase activities, and disruption of the antioxidant system, resulting in the disruption of intracellular reduction−oxidation homeostasis. Monacolin K also activated MAPK and NF-κB pathways, upregulating P38 activity and downregulating JNK/ERK/ P65/IκBα expression, ultimately leading to apoptosis of U251 cells. Importantly, monacolin K was not cytotoxic to normal human cells, hUC-MSCs. We concluded that monacolin K can induce apoptosis in U251 cells by triggering ROS-mediated oxidative damage and regulating MAPKs and NF-κB pathways.

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Section: Discussionmentioning

confidence: 62%

Monacolin K Induces Apoptosis of Human Glioma U251 Cells by Triggering ROS-Mediated Oxidative Damage and Regulating MAPKs and NF-κB Pathways

Shi

Huang

et al. 2023

ACS Chem. Neurosci.

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“…Microstructural alterations occur in MP integrity, resulting in a reduction in Ca 2+ -ATPase activity [33] . Following frozen storage, all samples showed a significant decrease in Ca 2+ -ATPase activity ( Fig.…”

Section: Resultsmentioning

confidence: 99%

Effects of multi-frequency ultrasound-assisted immersion freezing processing on myofibrillar protein structure and lipid oxidation of large yellow croaker (Larimichthys crocea) during long-time frozen storage

Yang,

Dong,

et al. 2024

Ultrasonics Sonochemistry

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Effects of postmortem chilling times and subsequent frozen storage durations on microstructure and protein properties of tilapia (Oreochromis niloticus) fillets

Wang,

et al. 2024

Food Measure

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Ca2+ATPase enzyme activities and lipid and protein oxidations of grass carp (Ctenopharyngodon idellus) stored at 4 °C for 30 min under electromagnetic fields

Cited by 18 publications

References 58 publications

Monacolin K Induces Apoptosis of Human Glioma U251 Cells by Triggering ROS-Mediated Oxidative Damage and Regulating MAPKs and NF-κB Pathways

Monacolin K Induces Apoptosis of Human Glioma U251 Cells by Triggering ROS-Mediated Oxidative Damage and Regulating MAPKs and NF-κB Pathways

Effects of multi-frequency ultrasound-assisted immersion freezing processing on myofibrillar protein structure and lipid oxidation of large yellow croaker (Larimichthys crocea) during long-time frozen storage

Effects of postmortem chilling times and subsequent frozen storage durations on microstructure and protein properties of tilapia (Oreochromis niloticus) fillets

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